Question: Glutaraldehyde polymerization ? 
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 Question: Glutaraldehyde polymerization ?

        Glutaraldehyde has been used in numerous biomedical applications  
as a very effective cross-linking agent (e.g. heparinized materials,  
hydrogel preparation & stabilization of heparin-albumin coated {*filter*}  
contacting devices such as catheters).
        Despite its popularity various drawbacks associated with the use  
of glutaraldehyde as a crosslinking agent, have been reported.  These  
include gradual release of undesirable by-products, secondary biological  
effects and a loss in the mechanical properties of the glutaraldehyde  
treated material. The latter has been attributed to a few uncontrolled  
factors, in particular the polymerization of the crosslinking agent  
leading  to a loss in the overall effectiveness of the reaction.
        In an initial attempt to shed more light on  secondary effects we  
question the existence of a simple assay that would allow for quantitative  
evaluation of the extent of glutaraldehyde polymerization in aqueous  
buffer solutions (pH 7.4).  Do you have any knowledge of such an assay?
Have you any other suggestions to estimate the extent of glutaraldehyde  
polymerization ?

        Dec 16 1993

        Robarts Research institute London Ontario
        (519) 663 5777 ext 4410

Tue, 04 Jun 1996 03:12:41 GMT
 [ 1 post ] 

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