Psychobiology, energy

Bob Oli
#1 / 10

energy

In my quest for more energy I have tried most of the ssri's, retilin,
Dexedrine, adrafinil, etc with no luck. In fact, the {*filter*}, that should
speed me up put me in the mood for a euphoric nap. Why? Ephedra makes me
feel awful. The only thing that seems to work is the pain killer Ultram.
But I soon build up a tolerance for it and just can't seem to make my self
up the dosage. It seem's that my mood is elevated with Ultram, and with the
elevated mood come energy and enthusiasm. Does anyone know what's going
on???

Bob

Wed, 30 May 2001 03:00:00 GMT

gene johnso
#2 / 10

energy

Quote:

> In my quest for more energy I have tried most of the ssri's, retilin,
> Dexedrine, adrafinil, etc with no luck. In fact, the {*filter*}, that should
> speed me up put me in the mood for a euphoric nap. Why? Ephedra makes me
> feel awful. The only thing that seems to work is the pain killer Ultram.
> But I soon build up a tolerance for it and just can't seem to make my self
> up the dosage. It seem's that my mood is elevated with Ultram, and with the
> elevated mood come energy and enthusiasm. Does anyone know what's going
> on???

> Bob

Might respond differently to caffeine or theophylline. Does a small amount of
{*filter*}
make you sleepy?

Gene

Thu, 31 May 2001 03:00:00 GMT

Larry Bras
#3 / 10

energy

Quote:

> In my quest for more energy I have tried most of the ssri's, retilin,
> Dexedrine, adrafinil, etc with no luck. In fact, the {*filter*}, that should
> speed me up put me in the mood for a euphoric nap. Why? Ephedra makes me
> feel awful. The only thing that seems to work is the pain killer Ultram.
> But I soon build up a tolerance for it and just can't seem to make my self
> up the dosage. It seem's that my mood is elevated with Ultram, and with the
> elevated mood come energy and enthusiasm. Does anyone know what's going
> on???

For us overseas readers, could you tell us the generic name for Ultram.
It might give me a clue.

People with ADHD often are sedated by stimulants, and stimulated by
sedatives. I wonder if this might apply to you.

--

Fri, 01 Jun 2001 03:00:00 GMT

#4 / 10

energy

Fri, 19 Jun 1992 00:00:00 GMT

F. Frank LeFev
#5 / 10

energy

Does anyone know current status of dihydrexidine? (a selective D-1
agonist) Investigational? What phase? Know of anyone doing clinical
trials?

F. Frank LeFever, Ph.D.
New York Neuropsychology Group

Fri, 01 Jun 2001 03:00:00 GMT

gene johnso
#6 / 10

energy

Quote:

> Does anyone know current status of dihydrexidine? (a selective D-1
> agonist) Investigational? What phase? Know of anyone doing clinical
> trials?

> F. Frank LeFever, Ph.D.
> New York Neuropsychology Group

Which D-1 second messenger does it target? Sounds interesting, as D-1
seems increasingly
important in dopaminergic excitatory effects.

Gene

Fri, 01 Jun 2001 03:00:00 GMT

F. Frank LeFev
#7 / 10

energy

Quote:

>> Does anyone know current status of dihydrexidine? (a selective D-1
>> agonist) Investigational? What phase? Know of anyone doing
clinical
>> trials?

>> F. Frank LeFever, Ph.D.
>> New York Neuropsychology Group

>Which D-1 second messenger does it target? Sounds interesting, as D-1
>seems increasingly
>important in dopaminergic excitatory effects.

>Gene

Maybe it's just a function of my ignorance, but I wouldn't have thought
it targeted any second messengers; my understanding is that it targets
the D-1 receptor--haven't noticed any discussion of differentiation
beyond that point.

Pat Goldman-Rakic has zeroed in on D-1 receptors as critical to
working-memory functions of the prefrontal cortex. Apparently they are
of some interest to those treating Parkinsonism also, perhaps (my weak
grasp of the principles) because of their modulation of D-2 receptors.

F. LeFever

- Show quoted text -

Sat, 02 Jun 2001 03:00:00 GMT

#8 / 10

energy

Fri, 19 Jun 1992 00:00:00 GMT

Arci
#9 / 10

energy

Bob,
Rather than continually changing to other meds to solve the problem why not have a complete work-up to see which part of the
neurochemical messaging system ineffective or deficient. Then after insuring that you are not depleting neurotransmitters with the
medications or that you are not already neurotranmitter deficient prior to using a medication, you can be more selective in your
choices. Specialty Labs in CA can do many of the tests, I'm sure there are others that can as well. I am a strong proponent for
making sure that the target tissue of any medication can and will actually receive the signal we want. Anything less just results
in a very expensive urine.

Arcie

Quote:

> In my quest for more energy I have tried most of the ssri's, retilin,
> Dexedrine, adrafinil, etc with no luck. In fact, the {*filter*}, that should
> speed me up put me in the mood for a euphoric nap. Why? Ephedra makes me
> feel awful. The only thing that seems to work is the pain killer Ultram.
> But I soon build up a tolerance for it and just can't seem to make my self
> up the dosage. It seem's that my mood is elevated with Ultram, and with the
> elevated mood come energy and enthusiasm. Does anyone know what's going
> on???

> Bob

Wed, 01 Aug 2001 03:00:00 GMT