rsvp.

+********** Snail me yer rosehips if you liked this post! ************
+ GABRIELLI WINERY (Mendocino,CA): Zinfandel, Ascenza (White-Blend), +
+         Syrah,  Pinot-Noir, Sangiovese Wines  --  Yummy!           +
*Better Living Thru Better Living!* http://www.***.com/ ~rugosa *

After doing a Medline I realized you were as competent as I.

Thanks for bringing it to my attention, however.

Foo

Database: med98-99 -- Record 1 of 3 selected.
Title
Action of the 5-HT2A antagonist amperozide on {*filter*}-induced poikilothermia in
rats.
Author
Myers RD; Lankford M
Address
Department of Pharmacology School of Medicine, East Carolina University,
Greenville, NC 27858, USA.
Source
Pharmacol Biochem Behav, 59(1):91-5 1998 Jan
Abstract
Amperozide, a novel 5-HT2A receptor antagonist that releases dopamine from
mesolimbic neurons suppresses {*filter*} drinking in rats. Because serotonergic
neurons are implicated in both the central mechanisms underlying
thermoregulation and the reinforcing effects of {*filter*}, this study was
undertaken to determine whether the poikilothermic effects of {*filter*} on body
temperature (Tb) would be altered by amperozide. In {*filter*} male Sprague-Dawley
rats kept at an ambient temperature of 22 to 24 degrees C, a radio transmitter
for continuous monitoring of Tb was first implanted intraperitoneally. Then,
amperozide was given subcutaneously in a dose of 2.5, 5.0, or 10.0 mg/kg 30 min
before an intragastric gavage of either 2.0 g/kg or 4.0 g/kg 20% ethyl {*filter*}
(v/v). Amperozide blocked dose dependently the fall in Tb of the lower 2.0 g/kg
dose of {*filter*}. However, only the higher 5.0 mg/kg and 10.0 mg/kg doses of
amperozide prevented the initial thermolytic action of the higher 4.0 g/kg dose
of {*filter*}. Further, the 10.0 mg/kg dose of amperozide given prior to the
control saline gavage evoked a hyperthermic response in the rats that persisted
for 5 h. These results suggest that the antagonism of 5-HT2A receptors on
central serotonergic synapses involved in thermoregulation acts to counteract
the potent thermolytic effects of {*filter*} at an ambient temperature that is
below thermoneutrality.
Language
Eng
Unique Identifier
98103778
MESH Headings
{*filter*}ism *DT/PP ; Animal ; Body Temperature Regulation *DE ; Male ;
Piperazines *TU ; Rats ; Rats, Sprague-Dawley ; Serotonin Antagonists *TU ;
Support, U.S. Gov't, P.H.S.
Publication Type
JOURNAL ARTICLE
ISSN
0091-3057
Country of Publication
UNITED STATES
CAS Registry Number
0 (Piperazines); 0 (Serotonin Antagonists); 75558-90-6 (amperozide)

Database: med98-99 -- Record 2 of 3 selected.
Title
Naltrexone and amperozide modify chocolate and saccharin drinking in high
{*filter*}-preferring P rats.
Author
Biggs TA; Myers RD
Address
Department of Pharmacology, School of Medicine, East Carolina University,
Greenville, NC 27858, USA.
Source
Pharmacol Biochem Behav, 60(2):407-13 1998 Jun
Abstract
Previous studies showed that the 5-HT2 receptor antagonist, amperozide, is
somewhat more potent than the opiate antagonist, naltrexone, in reducing {*filter*}
drinking in high {*filter*}-preferring (P) rats. The purpose of this study was to
determine in the P rat whether the effect of either drug could be due, in part,
to an alteration in gustatory function. In an unlimited, 24-h free choice
paradigm, P rats were offered water simultaneously with either a highly
palatable 0.1% saccharin solution or a 1:4 dilution of Nestle Sweet Success
chocolate drink. Throughout all phases of the study, the P rats always consumed
significantly greater volumes of the chocolate drink than of the saccharin
solution, i.e., 526 ml/kg vs. 181 ml/kg, respectively. Successive 12-day
experimental periods consisted of three phases: a 4-day predrug control
interval; 4 days of administration of saline control vehicle or either drug; and
a final 4 day postdrug interval. In a counterbalance design, saline, amperozide
(1.0 or 5.0 mg/kg) or naltrexone (2.5 or 5.0 mg/kg) was administered
subcutaneously twice daily at 1600 and 2200 h for 4 days. Amperozide and
naltrexone significantly reduced the drinking of chocolate in a dose-dependent
manner. Conversely, only the two higher doses of amperozide and naltrexone
decreased the intake of saccharin significantly. Thus, these findings suggest
that different populations of central serotonin and opioid receptors
concurrently underpin, in part, the preferences for both palatable and/or
nutrient fluids. Finally, because both the opiate and 5-HT2A antagonists reduce
the ingestion of saccharin and chocolate solutions differentially, it is
apparent that preferences for alternative palatable fluids should be examined
when candidate {*filter*} are screened for suppressing {*filter*} drinking and
ultimately the treatment of {*filter*} abuse.
Language
Eng
Unique Identifier
98294012
MESH Headings
{*filter*} Drinking *GE/*PX ; Animal ; Body Weight DE ; Cacao ; Dose-Response
Relationship, Drug ; Eating DE ; Male ; Naltrexone *PD ; Narcotic Antagonists
*PD ; Piperazines *PD ; Rats ; Rats, Inbred Strains ; Saccharin PD ; Serotonin
Antagonists *PD ; Support, U.S. Gov't, P.H.S. ; Sweetening Agents PD ; Taste *DE
Publication Type
JOURNAL ARTICLE
ISSN
0091-3057
Country of Publication
UNITED STATES
CAS Registry Number
0 (Narcotic Antagonists); 0 (Piperazines); 0 (Serotonin Antagonists); 0
(Sweetening Agents); 16590-41-3 (Naltrexone); 75558-90-6 (amperozide); 81-07-2
(Saccharin)

Database: med98-99 -- Record 3 of 3 selected.
Title
Effects of amperozide, 8-OH-DPAT, and FG 5974 on operant responding for ethanol.
Author
Roberts AJ; McArthur RA; Hull EE; Post C; Koob GF
Address
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA
92037, USA.
Source
Psychopharmacology (Berl), 137(1):25-32 1998 May
Abstract
Both 5-HT1A and 5-HT2A receptors have been implicated in modulating ethanol
self-administration. A novel serotonergic compound, FG 5974, with combined
5-HT1A agonist/5-HT2A antagonist activities, has shown effects in decreasing
ethanol consumption in two-bottle choice paradigms. In the present study, the
effect of this compound on operant responding for ethanol (as well as water and
a saccharin solution) was compared to compounds possessing the separate
neuropharmacological effects of this drug (the 5-HT1A agonist, 8-OH-DPAT, and
the 5-HT2A antagonist, amperozide). While all three serotonergic compounds
decreased operant responding for ethanol, only FG 5974 had no effect on water
and saccharin responding. These results suggest that combined 5HT1A
agonist/5-HT2A antagonist activity provides a more selective effect on ethanol
reinforcement than either neuropharmacological action alone. Therefore, further
analysis of mixed serotonergic compounds in general, and FG 5974 in particular,
is warranted as they offer potential treatments for {*filter*}ism.
Language
Eng
Unique Identifier
98293714
MESH Headings
Animal ; Conditioning, Operant *DE ; Ethanol BL/*PD ; Male ; Nicotinic Acids *PD
; Piperazines *PD ; Rats ; Rats, Wistar ; Receptors, Serotonin DE ; Serotonin
Agonists *PD ; Serotonin Antagonists *PD ; Support, Non-U.S. Gov't ; Support,
U.S. Gov't, P.H.S. ; 8-Hydroxy-2-(di-n-propylamino)tetralin *PD
HYDROXYDIPROPYLAMINOTETRALIN N 08 02
Publication Type
JOURNAL ARTICLE
ISSN
0033-3158
Country of Publication
GERMANY
CAS Registry Number
0 (serotonin 2A receptor); 0 (FG 5974); 0 (Nicotinic Acids); 0 (Piperazines); 0
(Receptors, Serotonin); 0 (Serotonin Agonists); 0 (Serotonin Antagonists);
112692-38-3 (serotonin 1A receptor); 64-17-5 (Ethanol); 75558-90-6 (amperozide);
78950-78-4 (8-Hydroxy-2-(di-n-propylamino)tetralin)

But what has any of this got to do with hemp ?
It's my understanding (and experience) that
hemp is not an {*filter*}ive substance.

Slyde