Anxiety + Depression Refractory to Standard Treatments 
Author Message
 Anxiety + Depression Refractory to Standard Treatments

I'm a 20 years old male. I've suffered for many years from:

* mild depression
* social anxiety with avoidant properties
* some distractability, normal attention span
  (with average functional IQ, high verbal IQ)
* lowered libido
* mild obsessive-copulsive properties of personality

I'm generally investegative and ambitious, yet lacks social
skills and have an unexplained tendency to cause bad impression
on various people, mostly after a lengthy contact (first
impression doesn't seem to form a problem). I do have friends,
and I did have a girlfriend, but I couldn't get along with most
people in high school, on my last 2 jobs (with very different
people!), on my neighbourhood, and so on... I'm good looking, I'm
intelligent and have a good sense of humour, yet it seems that
impaired self confidence and insensitivity to others are a
factor, but there are other factors that neither me nor others
can specify.

I've taken a variety of pharmacologic treatments for the past 2
years:

ADs: Fluoxetine (Prozac),Moclobemide (Manerix),
     Phenelzine (Nardil) and Paroxetine (Paxil).
BZs: Diazepam (Valium), Alprazolam (Xanax),
     Clonzaepam(Rivotril).

* Prozac caused me to be more anxious even after prolonged
administration, and after a while it caused me apathy and {*filter*}
dysfunction (Dopamine down regulation), which caused me to end
the treatment after 3 monthes at 20-40mg.
* Manerix didn't relieve anxiety, it even caused some
nervousness, but effectively relieved depression without gross
side effects. However, it does cause me to be a bit apathic to my
surrounding, feeling no need to talk or react, etc... (might be
also some sort of dopamine down regulation)
* Paxil did relieve some anxiety but had all the phenomena of
prozac, so I stopped taking it.
* Nardil (60-90 mg), did relieve anxiety, but apart from terrible
{*filter*} dysfunction, that didn't react to any anecdotal treatment
(buspirone, amantadine, cyproheptadine, methylphenidate,
yohimbine), it caused me severe constipation, dizziness, and
other SE. After 2 monthes it lost it's anxyholitic effect, and it
only relieved my depression. I ceased the treatment after another
month.

The BZs does help. I tend to produce tolerence to their effect
very rapidly, but I also doesn't have much difficulty in stopping
taking them (I did it about 5 times so far, even stopped 6mg/day
of clonazepam abruptly without much severe ill effects).

I've used clonazepam for most of the time, with and w/o ADs, and
it has relieved my social phobia. However, I become apathic,
insensitive, tend to interrupt conversations (something I've
always found hard to control), yet unable to motivate myself to
do things the way I want them (it often takes me great effort to
do simple stuff).

I stopped taking Clonazepam. I'm now on 1.5mg/day Xanax and
225mg/day Moclobemide. The main problem is that ADs doesn't
relieve my problem and make me either more avoidant or more
apathic, and BZs make me apathic too, so I get less motivated to
iteract with the environment, with all the implications )-:

I suspect that the pharmacologic treatment might be going to
improper directions, although it is given by a qualified
psychiatrist. It might be, to my opinion, that low dopamine
concentrations in D2 sites at the frontal lobe might be causing
some of the hassle.

I would like to hear your opinions and suggestions - professionals as 'lay' people. Any advice is welcome, as well as references to Web sources or books.

                                                  Thanks,
                                                  Jerry



Sat, 05 Jun 1999 03:00:00 GMT
 Anxiety + Depression Refractory to Standard Treatments

Quote:
> I'm a 20 years old male. I've suffered for many years from:

> * mild depression
> * social anxiety with avoidant properties
> * some distractability, normal attention span
>   (with average functional IQ, high verbal IQ)
> * lowered libido
> * mild obsessive-copulsive properties of personality

Similar to me, except I've normal libido, worse depression,
worse verbal skills, worse distractability and better than
average functional "IQ."

Quote:
> I'm generally investegative and ambitious, yet lacks social
> skills and have an unexplained tendency to cause bad impression
> on various people, mostly after a lengthy contact (first
> impression doesn't seem to form a problem).

That suggests low verbal "IQ."

Quote:
>                                             I do have friends,
> and I did have a girlfriend, but I couldn't get along with most
> people in high school, on my last 2 jobs (with very different
> people!), on my neighbourhood, and so on... I'm good looking, I'm
> intelligent and have a good sense of humour, yet it seems that
> impaired self confidence and insensitivity to others are a
> factor, but there are other factors that neither me nor others
> can specify.

> I've taken a variety of pharmacologic treatments for the past 2
> years:

> ADs: Fluoxetine (Prozac),Moclobemide (Manerix),
>      Phenelzine (Nardil) and Paroxetine (Paxil).
> BZs: Diazepam (Valium), Alprazolam (Xanax),
>      Clonzaepam(Rivotril).

I've found Diazepam unpleasant and ineffectual.

Quote:
> * Prozac caused me to be more anxious even after prolonged
> administration, and after a while it caused me apathy and {*filter*}
> dysfunction (Dopamine down regulation), which caused me to end
> the treatment after 3 monthes at 20-40mg.
> * Manerix didn't relieve anxiety, it even caused some
> nervousness, but effectively relieved depression without gross
> side effects. However, it does cause me to be a bit apathic to my
> surrounding, feeling no need to talk or react, etc... (might be
> also some sort of dopamine down regulation)
> * Paxil did relieve some anxiety but had all the phenomena of
> prozac, so I stopped taking it.

Paxil greatly relieved anxiety and deprssion with me, with bad
{*filter*} dysfunction for a couple months; I was surprised that I no
longer needed tranquilizers; my {*filter*} function fully revived,
but gradually, after a few months.

Quote:
> * Nardil (60-90 mg), did relieve anxiety, but apart from terrible
> {*filter*} dysfunction, that didn't react to any anecdotal treatment
> (buspirone, amantadine, cyproheptadine, methylphenidate,
> yohimbine), it caused me severe constipation, dizziness, and
> other SE. After 2 monthes it lost it's anxyholitic effect, and it
> only relieved my depression. I ceased the treatment after another
> month.

Well, Nardil is a MAO inhibiter, so it's not a first choice until
the SSR's like Paxil, Prozac, Zoloft, etc., have been tried.

- Show quoted text -

Quote:
> The BZs does help. I tend to produce tolerence to their effect
> very rapidly, but I also doesn't have much difficulty in stopping
> taking them (I did it about 5 times so far, even stopped 6mg/day
> of clonazepam abruptly without much severe ill effects).

> I've used clonazepam for most of the time, with and w/o ADs, and
> it has relieved my social phobia. However, I become apathic,
> insensitive, tend to interrupt conversations (something I've
> always found hard to control), yet unable to motivate myself to
> do things the way I want them (it often takes me great effort to
> do simple stuff).

> I stopped taking Clonazepam. I'm now on 1.5mg/day Xanax and
> 225mg/day Moclobemide. The main problem is that ADs doesn't
> relieve my problem and make me either more avoidant or more
> apathic, and BZs make me apathic too, so I get less motivated to
> iteract with the environment, with all the implications )-:

I was prescribed 1.5mg Xanax a day too.  Xanax shouldn't be used
regualrly, as it may say on the bottle, just use it as needed.
My usage varies between none and 2.00mg a day and has been
averaging 0.75mg a day over the last couple months.

Initially, I didn't like Xanax, but after reluctantly taking
about 3.00mg over a two week period it grew on me.  Benzos should
not be taken on a schedule, no matter what the doctor says; use
it as needed and you may use less than 1.5mg a day; you've got to
watch yourself as a hawk and be reluctant to use it to avoid
dependance.  Instead of taking Benzos on a schedule, why not just
carry it in your wallet; then you get the secure feeling of
always being able to control a panic attack just by knowing you
have the pills right with you at all times; even though all the
Benzos take about 45 minutes to take effect, there's a comforting
feeling in swallowing 0.5mg of Xanax and knowing that relief will
come.

--
Cheers!



Sat, 05 Jun 1999 03:00:00 GMT
 Anxiety + Depression Refractory to Standard Treatments

Quote:

> I'm a 20 years old male. I've suffered for many years from:

> * mild depression
> * social anxiety with avoidant properties
> * some distractability, normal attention span
>   (with average functional IQ, high verbal IQ)
> * lowered libido
> * mild obsessive-copulsive properties of personality

> I'm generally investegative and ambitious, yet lacks social
> skills and have an unexplained tendency to cause bad impression
> on various people, mostly after a lengthy contact (first
> impression doesn't seem to form a problem). I do have friends,
> and I did have a girlfriend, but I couldn't get along with most
> people in high school, on my last 2 jobs (with very different
> people!), on my neighbourhood, and so on... I'm good looking, I'm
> intelligent and have a good sense of humour, yet it seems that
> impaired self confidence and insensitivity to others are a
> factor, but there are other factors that neither me nor others
> can specify.

> I've taken a variety of pharmacologic treatments for the past 2
> years:

> ADs: Fluoxetine (Prozac),Moclobemide (Manerix),
>      Phenelzine (Nardil) and Paroxetine (Paxil).
> BZs: Diazepam (Valium), Alprazolam (Xanax),
>      Clonzaepam(Rivotril).

> * Prozac caused me to be more anxious even after prolonged
> administration, and after a while it caused me apathy and {*filter*}
> dysfunction (Dopamine down regulation), which caused me to end
> the treatment after 3 monthes at 20-40mg.
> * Manerix didn't relieve anxiety, it even caused some
> nervousness, but effectively relieved depression without gross
> side effects. However, it does cause me to be a bit apathic to my
> surrounding, feeling no need to talk or react, etc... (might be
> also some sort of dopamine down regulation)
> * Paxil did relieve some anxiety but had all the phenomena of
> prozac, so I stopped taking it.
> * Nardil (60-90 mg), did relieve anxiety, but apart from terrible
> {*filter*} dysfunction, that didn't react to any anecdotal treatment
> (buspirone, amantadine, cyproheptadine, methylphenidate,
> yohimbine), it caused me severe constipation, dizziness, and
> other SE. After 2 monthes it lost it's anxyholitic effect, and it
> only relieved my depression. I ceased the treatment after another
> month.

> The BZs does help. I tend to produce tolerence to their effect
> very rapidly, but I also doesn't have much difficulty in stopping
> taking them (I did it about 5 times so far, even stopped 6mg/day
> of clonazepam abruptly without much severe ill effects).

> I've used clonazepam for most of the time, with and w/o ADs, and
> it has relieved my social phobia. However, I become apathic,
> insensitive, tend to interrupt conversations (something I've
> always found hard to control), yet unable to motivate myself to
> do things the way I want them (it often takes me great effort to
> do simple stuff).

> I stopped taking Clonazepam. I'm now on 1.5mg/day Xanax and
> 225mg/day Moclobemide. The main problem is that ADs doesn't
> relieve my problem and make me either more avoidant or more
> apathic, and BZs make me apathic too, so I get less motivated to
> iteract with the environment, with all the implications )-:

> I suspect that the pharmacologic treatment might be going to
> improper directions, although it is given by a qualified
> psychiatrist. It might be, to my opinion, that low dopamine
> concentrations in D2 sites at the frontal lobe might be causing
> some of the hassle.

> I would like to hear your opinions and suggestions - professionals as 'lay' people. Any advice is welcome, as well as references to Web sources
or books.

>                                                   Thanks,
>                                                   JerryJerry,

I am sorry to hear that you are sufferring this lack of confidence and
uncomfortable social interactions. Having suffered simaliarly for over 20
years I reccommend some psycotherapy in conjunction with your medication.
Pyscotherapy over a period of time will help you unlearn behaviourable
patterns that have became ingrained in you during periods when you have
been unwell and unconfident. Medications like Prozac often cause
increased anxiety in the first few weeks to taking, so keep trying
medications until you get one you are happy with.

Believe in Yourself

JO



Sun, 06 Jun 1999 03:00:00 GMT
 
 [ 3 post ] 

 Relevant Pages 

1. Anxiety + Depression Refractory to Standard Treatments

2. Anxiety + Depression Refractory to Standard Treatments

3. Treatment ideas for refractory atypical depression

4. Natural Treatment For Stress, Anxiety and Depression

5. refractory depression

6. refractory depression

7. Caffeine/Nutrasweet & Depression/Anxiety/Prozac

8. CBS News: Negative ion therapy for depression / anxiety

9. CBS News: Negative ion therapy for depression / anxiety

10. Will an Appendicitus cause Depression/Anxiety

11. Negative ion therapy for depression and anxiety

12. Negative ion therapy for depression and anxiety


 
Powered by phpBB® Forum Software