Donepezil (as adjunctive Rx) for attentional-deficit symptom in "chronic fatigue" condition...??
Quote:
>> I'm wondering if anybody 'out there' might be able to offer me some
helpful
>> feedback in regards to the idea of trying (as a 'latest resort') the
>> 'anti-dementia' drug, Aricept (donepezil), in a case of "chronic
fatigue"
>> which features an attentional-deficit? (Currently treating both
the
>> attentional deficit and c/o "chronic fatigue" with Dexedrine and
Effexor,
>> with only partial improvement in each.)
>Hold out on doing that for a while. I think that the activity of
aricept
>is not strong enough to classify it as a stimulant.
>I was visiting a few neuropsych guys at $^#&() and they are finishing
>trials on a pro cholinergic drug for both indications that will be
better
>than aricept and other inhibitors of cholinerase.
>Andy
Yeah. Coming are various kinds of low dose irreversably binding
cholinesterase inhibitors (read: nerve gases) in prodrug and pill form.
Time to stalk up on the old Protopam in the EDs again.
Meanwhile, Aricept's worth a try. It won't leave you vomiting and
foaming and spastically dialing 911 and wishing your roommate had a
syringe of atropine, if you take too much. It's pretty benign and
there are a lot of anecdotal reports of chronic fatigue people finding
benefit from it. I know of no blinded trials, however.
