CFS/Fibromyalgia link to IC/CPPS? 
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 CFS/Fibromyalgia link to IC/CPPS?

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Quote:

> Many people with IC and CPPS report symptoms characteristic of chronic
> fatigue syndrome. Here's a teaser:

> --

> TNF-alpha and CFS

> This study suggests a significant increase of serum TNF-alpha in
> patients with CFS compared to non-CFS controls, supporting further
> examination of the role of proinflammatory mediators in CFS and the
> clinical testing of TNF-alpha blockers and other anti-inflammatory
> agents for treatment.

OK so these brilliant researchers believe that TNF-alpha just suddenly
increases for no reason?  Instead trying to find WHY TNF-alpha is elevated,
just block it - its more profitable for the drug companies that way, since
patients will have to take the blocker for life.  If TNF-alpha has increased
due to an infectious agent, then blocking it could potentially make the
infection worse.  Sounds like corticosteroids deja-vu.

Of course, I'm sure there are instances when reducing TNF-alpha is
desirable, but just to say "its elevated relative to the controls therefore
block it" is just as silly as telling a guy with 101 degree fever to take a
cold bath to lower his temp to normal.



Tue, 17 Sep 2002 03:00:00 GMT
 CFS/Fibromyalgia link to IC/CPPS?

Many people with IC and CPPS report symptoms characteristic of chronic
fatigue syndrome. Here's a teaser:

--

TNF-alpha and CFS

This study suggests a significant increase of serum TNF-alpha in
patients with CFS compared to non-CFS controls, supporting further
examination of the role of proinflammatory mediators in CFS and the
clinical testing of TNF-alpha blockers and other anti-inflammatory
agents for treatment.

Note: TNF-alpha is the human tumor necrosis factor alpha, a protein
of 157 amino acids with a wide range of pro-inflammatory actions,
usually considered to be a cytokine.

See this paper as:

   Moss RB, Mercandetti A, Vojdani A.  TNF-alpha and chronic fatigue
   syndrome.  J Clin Immunol 1999 Sep;19(5):314-6. PMID: 10535608,
   UI: 20004266



Tue, 17 Sep 2002 03:00:00 GMT
 CFS/Fibromyalgia link to IC/CPPS?

Quote:

> --

> > Many people with IC and CPPS report symptoms characteristic of chronic
> > fatigue syndrome. Here's a teaser:

> > --

> > TNF-alpha and CFS

> > This study suggests a significant increase of serum TNF-alpha in
> > patients with CFS compared to non-CFS controls, supporting further
> > examination of the role of proinflammatory mediators in CFS and the
> > clinical testing of TNF-alpha blockers and other anti-inflammatory
> > agents for treatment.

> OK so these brilliant researchers believe that TNF-alpha just suddenly
> increases for no reason?  Instead trying to find WHY TNF-alpha is elevated,
> just block it - its more profitable for the drug companies that way, since
> patients will have to take the blocker for life.  If TNF-alpha has increased
> due to an infectious agent, then blocking it could potentially make the
> infection worse.  Sounds like corticosteroids deja-vu.

Hardly, Nick. A worsening infection would make itself known chop-chop.

- Show quoted text -

Quote:
> Of course, I'm sure there are instances when reducing TNF-alpha is
> desirable, but just to say "its elevated relative to the controls therefore
> block it" is just as silly as telling a guy with 101 degree fever to take a
> cold bath to lower his temp to normal.



Tue, 17 Sep 2002 03:00:00 GMT
 
 [ 3 post ] 

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