Pretreatment total testosterone levels in patients with prostate cancer in Japan 
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 Pretreatment total testosterone levels in patients with prostate cancer in Japan

The just published Japanese study

Sekine Y, Ito K, Yamamoto T, Nakazato H, Shibata Y, Hatori M, Suzuki
K.
Pretreatment total testosterone levels in patients with prostate
cancer in the past two decades in Japan.
Cancer Detect Prev. 2007 Apr 5; [Epub ahead of print]
PMID: 17418977 [PubMed - as supplied by publisher]
< http://www.***.com/ ;

found that patients with poorly differentiated prostate cancer
had lower testosterone levels than the others.

Abstract:

    "Background: Many studies have shown the relationship between
    pretreatment serum testosterone levels and the clinical stage
    or histological grade, but the clinical significance of
    pretreatment testosterone levels is controversial. We studied
    the association of pretreatment total testosterone levels with
    the clinical stage and histological grade of prostate cancer.
    Methods: We evaluated 2914 patients whose pretreatment
    testosterone levels were recorded from 1982 to 2002. Serum
    testosterone levels were measured by radioimmunoassay. Results:
    There was a trend toward decreasing testosterone values with
    worsening clinical staging. There was a trend toward decreasing
    testosterone values with worsening histological grading, too.
    Patients with poorly differentiated adenocarcinoma had
    significantly lower testosterone levels than those with the
    others (versus well; p<0.01, moderately; p<0.01). Conclusions:
    Newly diagnosed patients with poorly differentiated
    adenocarcinoma of prostate have lower testosterone levels than
    the others."

--
Matti Narkia



Sun, 27 Sep 2009 08:25:01 GMT
 
 [ 2 post ] 

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