
Neurontin no better as a mood stabilizer than placebo studies that have been done clearly show
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Q: Neurontin as a Mood Stabilizer?
I am on 3200mg. of Neurontin a day. I recently read an article that said
Neurontin was not doing very well as a mood stablizer. Do you have any
information on this ?
Thank you,
Jayma
Dear Ms. J'
First principle: if someone's doing really well on something, with no side
effects, and that something doesn't carry a lot of risk, then in my business
there's not much reason to switch even if the research seems to indicate the
medication "shouldn't" be working! So, if you're doing well, you could ignore
that kind of talk. And, if you're not doing well, it may be time to look at
alternatives that have demonstrated "mood stabilizer" efficacy: lithium,
Depakote, carbamazepine now well substituted for by oxcarbazepine with less
risk; lamotrigine, and probably topiramate; and probably Zyprexa but weight is a
problem; and perhaps thyroid hormones, something we're just learning about.
It is true that Neurontin is not only "not doing well as a mood stablilizer".
The studies that have been done clearly show it to be no better as a mood
stabilizer than placebo (2 such, so far). No placebo controlled trial shows it
to be effective. Yet it has helped a lot of folks, generally by acting like an
antidepressant or anti-anxiety medication, in my view.
Dr. Phelps