Neurontin no better as a mood stabilizer than placebo studies that have been done clearly show 
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 Neurontin no better as a mood stabilizer than placebo studies that have been done clearly show

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Q:  Neurontin as a Mood Stabilizer?

I am on 3200mg. of Neurontin a day. I recently read an article that said
Neurontin was not doing very well as a mood stablizer. Do you have any
information on this ?

Thank you,
Jayma

Dear Ms. J'
First principle: if someone's doing really well on something, with no side
effects, and that something doesn't carry a lot of risk, then in my business
there's not much reason to switch even if the research seems to indicate the
medication "shouldn't" be working!   So, if you're doing well, you could ignore
that kind of talk.  And, if you're not doing well, it may be time to look at
alternatives that have demonstrated "mood stabilizer" efficacy: lithium,
Depakote, carbamazepine now well substituted for by oxcarbazepine with less
risk; lamotrigine, and probably topiramate; and probably Zyprexa but weight is a
problem; and perhaps thyroid hormones, something we're just learning about.  

It is true that Neurontin is not only "not doing well as a mood stablilizer".
The studies that have been done clearly show it to be no better as a mood
stabilizer than placebo (2 such, so far).  No placebo controlled trial shows it
to be effective.  Yet it has helped a lot of folks, generally by acting like an
antidepressant or anti-anxiety medication, in my view.

Dr. Phelps



Tue, 23 Nov 2004 14:27:42 GMT
 Neurontin no better as a mood stabilizer than placebo studies that have been done clearly show

Quote:

>The studies that have been done clearly show it to be no better as a mood
>stabilizer than placebo (2 such, so far).  No placebo controlled trial shows it
>to be effective.  Yet it has helped a lot of folks, generally by acting like an
>antidepressant or anti-anxiety medication, in my view.

The placebo effect!


Wed, 24 Nov 2004 17:10:34 GMT
 Neurontin no better as a mood stabilizer than placebo studies that have been done clearly show

Quote:

>>The studies that have been done clearly show it to be no better as a mood
>>stabilizer than placebo (2 such, so far).  No placebo controlled trial shows it
>>to be effective.  Yet it has helped a lot of folks, generally by acting like an
>>antidepressant or anti-anxiety medication, in my view.

>The placebo effect!

In a recent study comparing Zoloft, St. John's Wort, and placebo as
antidepressants, both St. John's Wort and Zoloft were effective for
about 25% of the subjects, but the placebo was effective for 32%.

Most of the antidepressants had to undergo a number studies by
their pharmaceutical company makers to find two that showed
significant effectiveness (the FDA requirement).

Personally, I still believe the antidepressants are worth taking.


Books on psychedelics, Mind Books: http://www.promind.com



Thu, 25 Nov 2004 01:47:58 GMT
 
 [ 3 post ] 

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