High-Fat Diets Trigger Changes in Brain Chemistry 
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 High-Fat Diets Trigger Changes in Brain Chemistry

High-Fat Diets Trigger Changes in Brain Chemistry
By Melissa Schorr

NEW YORK (Reuters Health) - High-fat diets trigger the brain to
produce peptides that may alter eating behaviors and body weight in
laboratory animals and lead to obesity, according to research
findings.

``The fats we eat affect the brain, then the brain determines how we
get fat,'' Sarah Leibowitz, associate professor of neurobiology at The
Rockefeller University in New York City, told Reuters Health.

Leibowitz presented her research recently at the American Chemical
Society meeting in Chicago, Illinois.

High-fat diets are known to raise the levels of lipids known as
triglycerides circulating in the {*filter*}. According to Leibowitz's
research, these triglycerides seem to stimulate genes in the brain's
hypothalamus to produce several neurochemicals. These chemicals in
turn produce neuropeptides, or proteins, which may interfere with the
feeling of fullness and alter fat storage.

In a study of young normal-weight rats fed an abnormally high-fat
diet, a rat's production of elevated triglyceride levels served as a
marker of the animal's later tendency to become obese.

The researchers identified two of these ``fat-responsive'' peptides as
orexin and galanin, which were overexpressed in rats with a tendency
to gain weight when put on this high-fat diet.

``A single high-fat meal is sufficient to stimulate the hypothalamic
expression of 'fat-responsive' genes that produce overeating, enhance
fat deposition and ultimately promote obesity,'' Leibowitz noted.



Thu, 04 Mar 2004 00:28:39 GMT
 High-Fat Diets Trigger Changes in Brain Chemistry
That is the dumbest thing I have ever heard. Who educated these guys?

Quote:
> High-Fat Diets Trigger Changes in Brain Chemistry
> By Melissa Schorr

> NEW YORK (Reuters Health) - High-fat diets trigger the brain to
> produce peptides that may alter eating behaviors and body weight in
> laboratory animals and lead to obesity, according to research
> findings.

> ``The fats we eat affect the brain, then the brain determines how we
> get fat,'' Sarah Leibowitz, associate professor of neurobiology at The
> Rockefeller University in New York City, told Reuters Health.

> Leibowitz presented her research recently at the American Chemical
> Society meeting in Chicago, Illinois.

> High-fat diets are known to raise the levels of lipids known as
> triglycerides circulating in the {*filter*}. According to Leibowitz's
> research, these triglycerides seem to stimulate genes in the brain's
> hypothalamus to produce several neurochemicals. These chemicals in
> turn produce neuropeptides, or proteins, which may interfere with the
> feeling of fullness and alter fat storage.

> In a study of young normal-weight rats fed an abnormally high-fat
> diet, a rat's production of elevated triglyceride levels served as a
> marker of the animal's later tendency to become obese.

> The researchers identified two of these ``fat-responsive'' peptides as
> orexin and galanin, which were overexpressed in rats with a tendency
> to gain weight when put on this high-fat diet.

> ``A single high-fat meal is sufficient to stimulate the hypothalamic
> expression of 'fat-responsive' genes that produce overeating, enhance
> fat deposition and ultimately promote obesity,'' Leibowitz noted.



Thu, 04 Mar 2004 03:37:53 GMT
 High-Fat Diets Trigger Changes in Brain Chemistry

Quote:
> High-fat diets are known to raise the levels of lipids known as
> triglycerides circulating in the {*filter*}. According to Leibowitz's
> research, these triglycerides seem to stimulate genes in the brain's
> hypothalamus to produce several neurochemicals. These chemicals in
> turn produce neuropeptides, or proteins, which may interfere with the
> feeling of fullness and alter fat storage.

yeah, galanin is the protein that fat intake increases... galanin
increases fat and to a lesser extent carbohydrate cravings..

but the reason for overfeeding in fat-fed rats is simply that fat is
only satieting in high-caloric amounts... you are much less likely to
"overfeed"(calories) on leaves(lettuce etc.) than you are on pure
lard..

i don't think this is because of the neuropetptides as the article
suggests... carbs also upregulate  carb preference neuropeptide-Y, not
necessarily overfeeding.......

anyway i think overfeeding in fat-fed rats is purely due to energy
density: 4 tablespoons of mayonnaise and you are overfed type of
thing...



Thu, 04 Mar 2004 07:39:36 GMT
 
 [ 3 post ] 

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