Flaxseed oil used in depression and BP illness 
Author Message
 Flaxseed oil used in depression and BP illness

Greetings fro NC!

Has anyone had any experience with flaxseed (as an adjunct med) oil used
to treat depression and cycling in Bipolar Dosoreder. What are the
recommended doses? I have read that 10 grams/day is suggested.

Thank you.

Reach beyond your grasp!



Fri, 19 Oct 2001 03:00:00 GMT
 Flaxseed oil used in depression and BP illness

Quote:
>Greetings fro NC!
>Has anyone had any experience with flaxseed (as an adjunct med) oil used
>to treat depression and cycling in Bipolar Dosoreder. What are the
>recommended doses? I have read that 10 grams/day is suggested.
>Thank you.

>Reach beyond your grasp!

I'd recommend checking out Donald Rudin's how-to books in this area before
proceeding.  He's the doctor who introduced the approach around 20 years ago.
People with BP are perhaps the ones who need to use the oil most cautiously.
Rudin himself has found that LSO -- typically at doses of two or more
tablespoons a day -- makes quite a high proportion of patients euphoric,
hyperactive, manic or hypomanic and may have triggered severe rapid-cycling in
one (she was only taking one tbsp a day). This doesn't mean that people with BP
(or a family history of same) can't benefit from LSO, only that they probably
must try it at a very conservative dosage, ideally under medical supervision and
with knowledge of the other complementary components of Rudin's program.
Perhaps (and this is just me speculating) ground flax seed would be a better
balanced and less "pharmacologic" (as in producing side effects) alternative to
large doses of the pure oil. Flax seed is about 50% oil.

Syd
                     _______________________

           http://www.escape.ca/~sgb

                     Dealing with Depression Naturally
                              and other books by Syd Baumel.
                                     ...and cool record reviews!



Fri, 19 Oct 2001 03:00:00 GMT
 Flaxseed oil used in depression and BP illness


Fri, 19 Jun 1992 00:00:00 GMT
 Flaxseed oil used in depression and BP illness
Mon, 3 May 1999 08:33:14 -0400 in article

Quote:

>Has anyone had any experience with flaxseed (as an adjunct med) oil used
>to treat depression and cycling in Bipolar Dosoreder. What are the
>recommended doses? I have read that 10 grams/day is suggested.

I don't know about use of flaxseed oil for depression or bipolar disorder,
but there has been some studies with another omega-3 fatty acid source:
fish oil. Rcently in a clinical trial conducted at Harvard University
found fish oil effective against bipolar disorder. The study will be
published this month in a major medical journal and a news report about it
can be found from the Washington Post's web page

Fish Oil May Aid Against Manic Depression
Study Attributes Dramatic Improvement in Patients to
Omega-3 Fatty Acids in Supplements
http://www.***.com/ :80/wp-srv/WPlate/1999-04/27/105l-042799...

A brief citation:

 ""The group taking the fish oil was performing strikingly better than
 the placebo group, including significantly longer periods of
 remission," said Andrew L. Stoll, director of the
 Psychopharmacology Research Laboratory at Harvard Medical
 School/McLean Hospital. "A decision was made to stop the trial on
 ethical grounds."

 Based on those promising findings, Stoll said, the National
 Institutes of Health (NIH) has given preliminary approval for a
 larger fish oil trial starting this summer. That trial, at McLean
 and Baylor College of Medicine in Houston, would include 120 people
 suffering from manic depression and would last for three years.

  "If this works, it would be one of the most exciting findings in
 psychiatry in the past 20 years," said Jerry Cott, chief of the
 psychopharmacology research program at the National Institute of
 Mental Health. "This is the first time we would be testing a
 nutritional supplement that appears to be having efficacy about to
 the degree of a synthetic medication.""

Web links about fish oil and depression:

Docosahexaenoic acid fights depression
http://www.***.com/
http://www.***.com/

Fish oil seen cutting risk of mental illness
http://www.***.com/ :80/dailyglobe/globehtml/247/Fish_oil_seen_cutti...

Researchers: Fat in the diet may affect mental ability
http://www.***.com/ :80/HEALTH/9809/04/fat.brains/

Fish May Cast Away Depression
 - Fish Oil Compounds Can Effect Seratonin Levels
 - Consumption Of Oil May Reduce Depression
http://www.***.com/ :80/prd1/now/template.display?p_story=77828&p_who=n...

MedLine references:

Joseph R Hibbeln. Fish consumption and major depression. The Lancet,
Volume 351, Number 9110 18, April 1998.
http://www.***.com/
http://www.***.com/

Peet M, Murphy B, Shay J, Horrobin D. Depletion of omega-3 fatty acid
levels in red {*filter*} cell membranes of depressive patients. Biol Psychiatry
1998 Mar 1;43(5):315-319
http://www.***.com/

Edwards R, Peet M, Shay J, Horrobin D. Omega-3 polyunsaturated fatty acid
levels in the diet and in red {*filter*} cell membranes of depressed patients.
J Affect Disord 1998 Mar;48(2-3):149-155
http://www.***.com/

Maes M, Smith R, Christophe A, Cosyns P, Desnyder R, Meltzer H. Fatty acid
composition in major depression: decreased omega 3 fractions in
cholesteryl esters and increased C20: 4 omega 6/C20:5 omega 3 ratio in
cholesteryl esters and phospholipids. J Affect Disord 1996 Apr
26;38(1):35-46
http://www.***.com/

Adams PB, Lawson S, Sanigorski A, Sinclair AJ. Arachidonic acid to
eicosapentaenoic acid ratio in {*filter*} correlates positively with clinical
symptoms of depression. Lipids 1996 Mar;31 Suppl:S157-S161
http://www.***.com/

Hibbeln JR, Salem N Jr. Dietary polyunsaturated fatty acids and
depression: when cholesterol does not satisfy. Am J Clin Nutr 1995 Jul
62:1 1-9
http://www.***.com/

Hibbeln JR, et al. Essential fatty acids predict metabolites of serotonin
and dopamine in cerebrospinal fluid among healthy control subjects, and
early- and late-onset {*filter*}ics.  Biol Psychiatry. 1998 Aug
15;44(4):235-42.
http://www.***.com/

Hibbeln JR, et al. A replication study of {*filter*} and non{*filter*} subjects:
cerebrospinal fluid metabolites of serotonin and dopamine are predicted by
plasma essential fatty acids. Biol Psychiatry. 1998 Aug 15;44(4):243-9.
http://www.***.com/

--
Matti Narkia



Sat, 20 Oct 2001 03:00:00 GMT
 Flaxseed oil used in depression and BP illness

Quote:

>I don't know about use of flaxseed oil for depression or bipolar disorder,
>but there has been some studies with another omega-3 fatty acid source:
>fish oil. Rcently in a clinical trial conducted at Harvard University
>found fish oil effective against bipolar disorder. The study will be
>published this month in a major medical journal and a news report about it
>can be found from the Washington Post's web page

It may be also interesting that it has been found that cyclooxygenase
may be hyperactive in schizophrenic patients. Do have a look at

 Das I, et al.           [See Related Articles]
     Increased arachidonic acid induced platelet chemiluminescence
indicates cyclooxygenase overactivity in schizophrenic subjects.
     Prostaglandins Leukot Essent Fatty Acids. 1998 Mar;58(3):165-8.
     PMID: 9610837; UI: 98272393.

Abstract:
Prostaglandins Leukot Essent Fatty Acids 1998 Mar;58(3):165-8

Increased arachidonic acid induced platelet chemiluminescence indicates
cyclooxygenase overactivity in
schizophrenic subjects.

Das I, Khan NS

Department of Psychiatry, Imperial College School of Medicine, London,
UK.

Platelets were found to emit a burst of chemiluminescence during
incubation with arachidonic or linoleic acid. This chemiluminescence
response may indicate activation of the enzyme
prostaglandin synthase in the arachidonate-induced platelet
chemiluminescence as it is inhibited by aspirin. Stimulation of
platelets with arachidonic acid and linoleic acid induced a
concentration dependent chemiluminescence response. Platelets from drug
naive schizophrenic subjects showed significantly increased arachidonic
acid metabolism compared to control
subjects. No significant difference was observed between schizophrenic
and control subjects in the chemiluminescence response to linoleic acid.
In schizophrenic subjects treated with
neuroleptic {*filter*} the overactive arachidonic acid response was
normalized. Linoleic acid chemiluminescence response was unaffected by
neuroleptic treatment. Hyperactive
cyclooxygenase activity may reflect a similar condition in the brain and
implicates prostaglandin pathway abnormalities in the pathogenesis of
schizophrenia.

PMID: 9610837, UI: 98272393

This mean that fish oil also here may have an interesting effect since
it is an inhibitor of PG2 syntesis by competing for the active site as
an alternative susbtrate. It binds strongly to the catalytic site and is
a very poor substrate, giving a Vm of about 10% of arachidonate as
substrate. (And a Km at a round 10% og Km of arachidonate)

---------------------------------
Alf Christophersen, Computer engineer
University of Oslo
Tel. +47 22 85 13 27, Fax: 22 85 15 32
URL: http://www.***.com/ ~achristo



Sun, 21 Oct 2001 03:00:00 GMT
 Flaxseed oil used in depression and BP illness


Fri, 19 Jun 1992 00:00:00 GMT
 Flaxseed oil used in depression and BP illness
And, is there any information (not hype; I can find plenty of that) on
increasing "good" prostaglandins to counteract anxiety? I've started
using Evening Primrose Oil but without any conclusions so far.
Quote:

>Greetings fro NC!
>Has anyone had any experience with flaxseed (as an adjunct med) oil used
>to treat depression and cycling in Bipolar Dosoreder. What are the
>recommended doses? I have read that 10 grams/day is suggested.
>Thank you.

>Reach beyond your grasp!



Wed, 24 Oct 2001 03:00:00 GMT
 Flaxseed oil used in depression and BP illness

Quote:

>The only thing that the EPO (omega-6 source) is going to do is increase the
>TOTAL number of all PGs. This is exactly what some people need as they lack
>enough of all PGs.
>However, ...

Wow! Extremely good information yet clear as mud and probably with
good reason, i.e., no cookie cutter answers to "curing" anxiety. For
several days now I've taken one 500mg epo 30 to 45 minutes prior to
turning out the lights for sleep and for the first time I'm sleeping
through the entire night. I'm pretty sure it's not a placebo effect
(long story).  So, I guess the bottom line is that *so far* the epo is
good for easing the anxiety I experience.


Sun, 28 Oct 2001 03:00:00 GMT
 Flaxseed oil used in depression and BP illness

Quote:
> Wow! Extremely good information yet clear as mud and probably with
> good reason, i.e., no cookie cutter answers to "curing" anxiety

If she had known you were reading this thread and that EPO helps you
she could have skipped the info on other causes for other readers.

t_mex

--== Sent via Deja.com http://www.deja.com/ ==--
---Share what you know. Learn what you don't.---



Mon, 29 Oct 2001 03:00:00 GMT
 Flaxseed oil used in depression and BP illness

Quote:
> Wow! Extremely good information yet clear as mud and probably with
> good reason, i.e., no cookie cutter answers to "curing" anxiety. For
> several days now I've taken one 500mg epo 30 to 45 minutes prior to
> turning out the lights for sleep and for the first time I'm sleeping
> through the entire night. I'm pretty sure it's not a placebo effect
> (long story).  So, I guess the bottom line is that *so far* the epo is
> good for easing the anxiety I experience.

A lot of people on the alt.herbs message group are healers who are here
to learn exactly when something will work and when it won't. A symptom
can have many possible causes, and what helps one person may not help
or may even hurt another because the underlying cause of the symptom is
different.  It's irresponsible for a healer not to be aware of the
possible underlying causes of a particular symptom and the different
treatments for different people. No herbalist - or any other healer -
can pinpoint a cause and treatment over a message group.  So what a lot
of people on here will do is give readers ideas on things to consider
and look into in case a particular treatment isn't working or is
causing problems.

I'm glad the EPO is helping you.  But not everyone with anxiety has the
same underlying cause that you have. And, there are a lot of people
reading this message group besides you. To suggest EPO for every person
with anxiety is irresponsible because it won't help some cases of
anxiety and in some cases it will make anxiety worse. Many of the
regular posters on this message group are professional herbalists and
will go into detail about when a particular treatment will not work and
why it won't work or even hurt.

If the concept of not everyone being your genetic twin and reacting
like you do is too hard to grasp, I suggest you stick with the simpler
posts - like those horrible spammed ads promising one miracle cure for
everything from acne to flat feet for everyone. And lose the sarcasm.

Victoria Dragon

--== Sent via Deja.com http://www.deja.com/ ==--
---Share what you know. Learn what you don't.---



Mon, 29 Oct 2001 03:00:00 GMT
 Flaxseed oil used in depression and BP illness
On the other hand, I suggest that you start reading posts and don't
skip the big words of more than one syllable and focus on
comprehension.
a. I qualified in *her defense* that there is no "cookie cutter"
answer for treating anxiety because there are so many things that can
contribute to it.
b. I specifically went on to state that *I* am being helped by it.
"I", as in "me". I didn't recommend that ANYONE try it. I just said
that I use it and SO FAR it's helping. Sheeeeesh.
Quote:

>> Wow! Extremely good information yet clear as mud and probably with
>> good reason, i.e., no cookie cutter answers to "curing" anxiety. For
>> several days now I've taken one 500mg epo 30 to 45 minutes prior to
>> turning out the lights for sleep and for the first time I'm sleeping
>> through the entire night. I'm pretty sure it's not a placebo effect
>> (long story).  So, I guess the bottom line is that *so far* the epo is
>> good for easing the anxiety I experience.
>A lot of people on the alt.herbs message group are healers who are here
>to learn exactly when something will work and when it won't. A symptom
>can have many possible causes, and what helps one person may not help
>or may even hurt another because the underlying cause of the symptom is
>different.  It's irresponsible for a healer not to be aware of the
>possible underlying causes of a particular symptom and the different
>treatments for different people. No herbalist - or any other healer -
>can pinpoint a cause and treatment over a message group.  So what a lot
>of people on here will do is give readers ideas on things to consider
>and look into in case a particular treatment isn't working or is
>causing problems.
>I'm glad the EPO is helping you.  But not everyone with anxiety has the
>same underlying cause that you have. And, there are a lot of people
>reading this message group besides you. To suggest EPO for every person
>with anxiety is irresponsible because it won't help some cases of
>anxiety and in some cases it will make anxiety worse. Many of the
>regular posters on this message group are professional herbalists and
>will go into detail about when a particular treatment will not work and
>why it won't work or even hurt.
>If the concept of not everyone being your genetic twin and reacting
>like you do is too hard to grasp, I suggest you stick with the simpler
>posts - like those horrible spammed ads promising one miracle cure for
>everything from acne to flat feet for everyone. And lose the sarcasm.
>Victoria Dragon
>--== Sent via Deja.com http://www.deja.com/ ==--
>---Share what you know. Learn what you don't.---



Mon, 29 Oct 2001 03:00:00 GMT
 Flaxseed oil used in depression and BP illness
You were sarcastic. How dare someone post something that didn't apply
to you!

It sounds like you're someone who routinely puts other people down, but
because you offer "qualifiers" no one is supposed to object.

t_mex

--== Sent via Deja.com http://www.deja.com/ ==--
---Share what you know. Learn what you don't.---



Mon, 29 Oct 2001 03:00:00 GMT
 
 [ 15 post ] 

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