
Flaxseed oil used in depression and BP illness
Mon, 3 May 1999 08:33:14 -0400 in article
Quote:
>Has anyone had any experience with flaxseed (as an adjunct med) oil used
>to treat depression and cycling in Bipolar Dosoreder. What are the
>recommended doses? I have read that 10 grams/day is suggested.
I don't know about use of flaxseed oil for depression or bipolar disorder,
but there has been some studies with another omega-3 fatty acid source:
fish oil. Rcently in a clinical trial conducted at Harvard University
found fish oil effective against bipolar disorder. The study will be
published this month in a major medical journal and a news report about it
can be found from the Washington Post's web page
Fish Oil May Aid Against Manic Depression
Study Attributes Dramatic Improvement in Patients to
Omega-3 Fatty Acids in Supplements
http://www.***.com/ :80/wp-srv/WPlate/1999-04/27/105l-042799...
A brief citation:
""The group taking the fish oil was performing strikingly better than
the placebo group, including significantly longer periods of
remission," said Andrew L. Stoll, director of the
Psychopharmacology Research Laboratory at Harvard Medical
School/McLean Hospital. "A decision was made to stop the trial on
ethical grounds."
Based on those promising findings, Stoll said, the National
Institutes of Health (NIH) has given preliminary approval for a
larger fish oil trial starting this summer. That trial, at McLean
and Baylor College of Medicine in Houston, would include 120 people
suffering from manic depression and would last for three years.
"If this works, it would be one of the most exciting findings in
psychiatry in the past 20 years," said Jerry Cott, chief of the
psychopharmacology research program at the National Institute of
Mental Health. "This is the first time we would be testing a
nutritional supplement that appears to be having efficacy about to
the degree of a synthetic medication.""
Web links about fish oil and depression:
Docosahexaenoic acid fights depression
http://www.***.com/
http://www.***.com/
Fish oil seen cutting risk of mental illness
http://www.***.com/ :80/dailyglobe/globehtml/247/Fish_oil_seen_cutti...
Researchers: Fat in the diet may affect mental ability
http://www.***.com/ :80/HEALTH/9809/04/fat.brains/
Fish May Cast Away Depression
- Fish Oil Compounds Can Effect Seratonin Levels
- Consumption Of Oil May Reduce Depression
http://www.***.com/ :80/prd1/now/template.display?p_story=77828&p_who=n...
MedLine references:
Joseph R Hibbeln. Fish consumption and major depression. The Lancet,
Volume 351, Number 9110 18, April 1998.
http://www.***.com/
http://www.***.com/
Peet M, Murphy B, Shay J, Horrobin D. Depletion of omega-3 fatty acid
levels in red {*filter*} cell membranes of depressive patients. Biol Psychiatry
1998 Mar 1;43(5):315-319
http://www.***.com/
Edwards R, Peet M, Shay J, Horrobin D. Omega-3 polyunsaturated fatty acid
levels in the diet and in red {*filter*} cell membranes of depressed patients.
J Affect Disord 1998 Mar;48(2-3):149-155
http://www.***.com/
Maes M, Smith R, Christophe A, Cosyns P, Desnyder R, Meltzer H. Fatty acid
composition in major depression: decreased omega 3 fractions in
cholesteryl esters and increased C20: 4 omega 6/C20:5 omega 3 ratio in
cholesteryl esters and phospholipids. J Affect Disord 1996 Apr
26;38(1):35-46
http://www.***.com/
Adams PB, Lawson S, Sanigorski A, Sinclair AJ. Arachidonic acid to
eicosapentaenoic acid ratio in {*filter*} correlates positively with clinical
symptoms of depression. Lipids 1996 Mar;31 Suppl:S157-S161
http://www.***.com/
Hibbeln JR, Salem N Jr. Dietary polyunsaturated fatty acids and
depression: when cholesterol does not satisfy. Am J Clin Nutr 1995 Jul
62:1 1-9
http://www.***.com/
Hibbeln JR, et al. Essential fatty acids predict metabolites of serotonin
and dopamine in cerebrospinal fluid among healthy control subjects, and
early- and late-onset {*filter*}ics. Biol Psychiatry. 1998 Aug
15;44(4):235-42.
http://www.***.com/
Hibbeln JR, et al. A replication study of {*filter*} and non{*filter*} subjects:
cerebrospinal fluid metabolites of serotonin and dopamine are predicted by
plasma essential fatty acids. Biol Psychiatry. 1998 Aug 15;44(4):243-9.
http://www.***.com/
--
Matti Narkia