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Wuzz
#1 / 7
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 Cytochrome P450 Naturopathic and orthomolecular nutritionists are interested in CP450: found in the liver, CP450 breaks down {*filter*} (sometimes into products that are worse), breaks down steroids and is also involved in steroidogenesis (ex. the formation of testosterone and also SHBG).. being such an important compound, can anyone share any info
about this?
For instance: In the book "The Secrets to Great Health",
Dr. Jonn Matsen recommends eating foods with high
Indole-3-Carbonyl (such as brussel sprouts) because I3C
increases some CP450s such as CP4501 and CP4502, thereby
causing the hydroxylation of testosterone and the breakdown
of estradiol (which causes {*filter*} cancer)...
in the same page (!), Dr. Matsen also recommends consuming
Grapefruits because they contain Naringen, a compound that
has been shown to inhibit CP450, and thus reduces risk of
cancer. (also patients consuming grapefruit will have higher
amounts of {*filter*} circulating)
does anyone have any info on CP450, especially whether
consuming I3C can reduce prostatee and {*filter*} cancer by
increasing hydroxylation of steroids?
(as i said, cp450-17 is involved in steroidogenesis, which
is contradictory)
also, there is research that Bean Sprouts (mung beans) can
mimic cp450 in humans and hydroxylate pregnenolone..
please reply...
and visit my page: http://www.***.com/
* Sent from AltaVista http://www.***.com/ Where you can also find related Web Pages, Images, Audios, Videos, News, and Shopping. Smart is Beautiful
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| Tue, 12 Nov 2002 03:00:00 GMT |
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Konni
#2 / 7
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Cytochrome P450 Contact me on CP450
Quote: > Naturopathic and orthomolecular nutritionists are interested > in CP450: found in the liver, CP450 breaks down {*filter*} > (sometimes into products that are worse), breaks down > steroids and is also involved in steroidogenesis (ex. the > formation of testosterone and also SHBG).. > being such an important compound, can anyone share any info
> about this?
> For instance: In the book "The Secrets to Great Health",
> Dr. Jonn Matsen recommends eating foods with high
> Indole-3-Carbonyl (such as brussel sprouts) because I3C
> increases some CP450s such as CP4501 and CP4502, thereby
> causing the hydroxylation of testosterone and the breakdown
> of estradiol (which causes {*filter*} cancer)...
> in the same page (!), Dr. Matsen also recommends consuming
> Grapefruits because they contain Naringen, a compound that
> has been shown to inhibit CP450, and thus reduces risk of
> cancer. (also patients consuming grapefruit will have higher
> amounts of {*filter*} circulating)
> does anyone have any info on CP450, especially whether
> consuming I3C can reduce prostatee and {*filter*} cancer by
> increasing hydroxylation of steroids?
> (as i said, cp450-17 is involved in steroidogenesis, which
> is contradictory)
> also, there is research that Bean Sprouts (mung beans) can
> mimic cp450 in humans and hydroxylate pregnenolone..
> please reply...
> and visit my page: http://www.***.com/
> * Sent from AltaVista http://www.***.com/ Where you can also find related Web Pages, Images, Audios, Videos, News, and Shopping. Smart is Beautiful
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| Thu, 14 Nov 2002 03:00:00 GMT |
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Adele
#3 / 7
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Cytochrome P450 Hiya, I have a couple of questions on Cytochome P450 too. Should I ask here in the forum or (assuming you have time to answer!)would it be ok to email you direct too??? Many thanks, Adele.
Quote: > Contact me on CP450
> > Naturopathic and orthomolecular nutritionists are interested
> > in CP450: found in the liver, CP450 breaks down {*filter*}
> > (sometimes into products that are worse), breaks down
> > steroids and is also involved in steroidogenesis (ex. the
> > formation of testosterone and also SHBG)..
> > being such an important compound, can anyone share any info
> > about this?
> > For instance: In the book "The Secrets to Great Health",
> > Dr. Jonn Matsen recommends eating foods with high
> > Indole-3-Carbonyl (such as brussel sprouts) because I3C
> > increases some CP450s such as CP4501 and CP4502, thereby
> > causing the hydroxylation of testosterone and the breakdown
> > of estradiol (which causes {*filter*} cancer)...
> > in the same page (!), Dr. Matsen also recommends consuming
> > Grapefruits because they contain Naringen, a compound that
> > has been shown to inhibit CP450, and thus reduces risk of
> > cancer. (also patients consuming grapefruit will have higher
> > amounts of {*filter*} circulating)
> > does anyone have any info on CP450, especially whether
> > consuming I3C can reduce prostatee and {*filter*} cancer by
> > increasing hydroxylation of steroids?
> > (as i said, cp450-17 is involved in steroidogenesis, which
> > is contradictory)
> > also, there is research that Bean Sprouts (mung beans) can
> > mimic cp450 in humans and hydroxylate pregnenolone..
> > please reply...
> > and visit my page: http://www.***.com/
> > * Sent from AltaVista http://www.***.com/ Where you can also
find related Web Pages, Images, Audios, Videos, News, and Shopping. Smart is Beautiful
Sent via Deja.com http://www.***.com/
Before you buy.
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| Fri, 15 Nov 2002 03:00:00 GMT |
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Wuzz
#4 / 7
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Cytochrome P450 e-mail is ok.. also if you post here, there is more feedback.. anyway, new quote from a book i'm reading (same as before,
lol, am i still reading that?)
Secrets of Great Health Dr. Matsen, pg. 268:
"Everyoen shold keep his or her P450 running as fast as the
conjugation enzymes can keep up"
..conjugation enzymes, of course being the ones that
deactivate the carcinogens that p450 lets loose:
conjugation enzymes, like glutathione/sulforaphane is found
mostly in broccoli sprouts and brussel sprouts.
Also, ppl with access to PubMed, do a search on the above
words, extremely iimportant articles come up:
ex. 1) Broccoli sprouts in cancer prevention:
Nutrition Reviews. 1998; 56/4 1 (pg.127-130)
(Article on how broccoli sprouts supports phase 2
conjugation enzymes therebye preventing cancer)
p450 enzymes are important in every regards: whether you are
taking supplements/{*filter*} or concerned about cancer...
especially hormonal and chemically related cancers.
(the liver, I would argue is one the most important organ we
have for digestion.. ok, so is the pancreas and stomach and
kidneys (for the skin).. yipers.)
* Sent from AltaVista http://www.***.com/ Where you can also find related Web Pages, Images, Audios, Videos, News, and Shopping. Smart is Beautiful
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| Fri, 15 Nov 2002 03:00:00 GMT |
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Joe Stude
#5 / 7
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Cytochrome P450 There are allot of conflicting statements about CYPP450s in the liver. One I find interesting is that some doctors apparently say fasting increases P450 production and therefore do not recommend fasting. Im a believer in fasting myself. I worked with P450s in academia. They are heme proteins.(not compounds) Just a friendly nomenclature suggestion. They are involved with the activation of oxygen for the formation of hydroxide formation. This means steroids and as you stated the transformation of xenobiotics to more water soluble (and sometimes more toxic) compounds so they can be excreted from the body. I can give you a couple of technical references if you want but they are purely chemical texts that may not help you in you pursuit of physiological relevance. P450s are vital to life. and I believe a proper (clean by standards of health nuts) diet will create the conditions for proper proportions of these enzymes. Sometime we over analyze the complex system of the living cell with the peaces of information we have and this leads us to think of strange and unlogical "rules" like eating been sprouts is bad for us. Balance and variety are best. In my opinion. Quote:
> Naturopathic and orthomolecular nutritionists are interested > in CP450: found in the liver, CP450 breaks down {*filter*} > (sometimes into products that are worse), breaks down > steroids and is also involved in steroidogenesis (ex. the > formation of testosterone and also SHBG).. > being such an important compound, can anyone share any info
> about this?
> For instance: In the book "The Secrets to Great Health",
> Dr. Jonn Matsen recommends eating foods with high
> Indole-3-Carbonyl (such as brussel sprouts) because I3C
> increases some CP450s such as CP4501 and CP4502, thereby
> causing the hydroxylation of testosterone and the breakdown
> of estradiol (which causes {*filter*} cancer)...
> in the same page (!), Dr. Matsen also recommends consuming
> Grapefruits because they contain Naringen, a compound that
> has been shown to inhibit CP450, and thus reduces risk of
> cancer. (also patients consuming grapefruit will have higher
> amounts of {*filter*} circulating)
> does anyone have any info on CP450, especially whether
> consuming I3C can reduce prostatee and {*filter*} cancer by
> increasing hydroxylation of steroids?
> (as i said, cp450-17 is involved in steroidogenesis, which
> is contradictory)
> also, there is research that Bean Sprouts (mung beans) can
> mimic cp450 in humans and hydroxylate pregnenolone..
> please reply...
> and visit my page: http://www.***.com/
> * Sent from AltaVista http://www.***.com/ Where you can also find related Web Pages, Images, Audios, Videos, News, and Shopping. Smart is Beautiful
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| Fri, 15 Nov 2002 03:00:00 GMT |
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John 'the Man'
#6 / 7
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Cytochrome P450
Quote: >Sometime we over analyze the complex system of the living cell with the
>peaces of information we have and this leads us to think of strange
>and unlogical "rules" like eating been sprouts is bad for us.
Eating bean sprouts is bad for you, so says Dr. Andrew Weils, MD. There is nothing unlogical about this rule. Beans contains toxins that can
be destroyed by cooking. And the stomach digests all living foods. So, by
the time the stomach gets through with those bean sprouts, they might as
well have been canned as fresh. :-)
--
P.S.: I post comments, I NEVER answer questions on ngs.
John Gohde,
Natural Health Advocate of the Healing Power of Nature.
http://home.att.net/~johngohde/
Civility often demands compromise. In compromise, no one gets exactly what
they want. Anybody who expects ONLY their ANSWER to their QUESTION is NOT
being very civil by definition.
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| Wed, 20 Nov 2002 03:00:00 GMT |
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Alf Christophers
#7 / 7
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Cytochrome P450 On Sat, 03 Jun 2000 15:31:26 GMT, "John 'the Man'" Quote:
>>Sometime we over analyze the complex system of the living cell with the
>>peaces of information we have and this leads us to think of strange
>>and unlogical "rules" like eating been sprouts is bad for us.
>Eating bean sprouts is bad for you, so says Dr. Andrew Weils, MD.
>There is nothing unlogical about this rule. Beans contains toxins that can
>be destroyed by cooking. And the stomach digests all living foods. So, by
>the time the stomach gets through with those bean sprouts, they might as
>well have been canned as fresh. :-)
Are you sure that the sprouts contains lectins ? I only know that some bean seeds may contain it (mostly P. coccineus) but beans mostly used, like brown cooking.net">food beans are quite low in the toxins, and I realy doubt if the sprouts contain them. Has Mr. Weils some analysis to prove his sayings ??
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| Wed, 20 Nov 2002 03:00:00 GMT |
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