1: Virus Genes 2001;23(2):211-4 Related Articles, Nucleotide, PopSet, Protein,
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Phylogeny of Thogoto virus.

Kuno G, Chang GJ, Tsuchiya KR, Miller BR.

Division of Vector-Borne Infectious Diseases, National Center for Infectious
Diseases, Centers for Disease Control and Prevention, Fort Collins, CO

Thogoto virus is a tick-borne member of the family Orthomyxoviridae.
Previously, based on the similarity in antigenic relationship by
cross-neutralization test, all virus strains were concluded to have derived
from the same origin. In this study, we obtained partial gene sequences of 4
genes (PB1-like protein, PA-like protein, glycoprotein, and nucleoprotein) of 8
Thogoto virus strains isolated in Africa, Asia, and Europe and studied the
genetic variation and phylogeny. Unrooted phylogenetic trees created by both
neighbor-joining and maximum likelihood methods based on nucleotide and amino
acid sequences for 4 genes were mostly similar and revealed two lineages,
Euro-Asian and African. Intra-lineage nucleotide sequence variation was greater
in the Euro-Asian lineage than in the African lineage for all 4 genes.
Furthermore, for the strains of Euro-Asian lineage, variations for two genes
associated with RNA-dependent RNA polymerase activities were greater than those
for glycoprotein or nucleoprotein gene, based on both nucleotide and amino acid
sequence differences as well as on synonymous and nonsynonymous differences,
indicating greater mutation rates for the polymerase activity genes in these
strains.

PMID: 11724276 [PubMed - in process]