2001: Differential Diagnosis of MS 
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 2001: Differential Diagnosis of MS

1: Neurol Sci 2001 Nov;22 Suppl 2:S98-102 Related Articles, Books, LinkOut  

The differential diagnosis of multiple sclerosis: classification and clinical
features of relapsing and progressive neurological syndromes.

Trojano M, Paolicelli D.

Department of Neurological and Psychiatric Sciences, University of Bari, Italy.

In the absence of pathognomonic clinical features or a definitive laboratory
test, multiple sclerosis (MS) remains ultimately a diagnosis of exclusion.
Accurate diagnosis is increasingly important with available disease modifying
therapy. Unfortunately the rate of misdiagnosis remains around 5%-10%,
indicating that 1 in 20 patients thought to have MS has, instead, a condition
resembling MS. In this review we describe conditions that may be confused with
MS because they can present as lesions disseminated in time, space, or both.
Conditions often confused with MS may be inflammatory (systemic lupus
erythematosus, Sjogren's syndrome, vasculitis, sarcoidosis, Behcet's disease),
infectious (Lyme disease, syphilis, progressive multifocal leukoencephalopathy,
HTLV-1 infection, herpes zoster), genetic (lysosomal disorders,
adrenoleukodystrophy, mitochondrial disorders, CADASIL), metabolic (vitamin B12
deficiency), neoplastic (CNS lymphoma) and spinal (degenerative and vascular
malformations) diseases. The key to the accurate diagnosis of MS is vigilance
for atypical features, suggesting the possibility of an alternative diagnosis.

PMID: 11794488 [PubMed - in process]

Tue, 06 Jul 2004 01:21:30 GMT
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