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1: Med Hypotheses 2001 Sep;57(3):292-301 Related Articles, Books, LinkOut  

Is multiple sclerosis caused by a silent infection with malarial parasites? A
historico-epidemiological approach: part II.

Kissler H.

Butzbach, Germany

The comparison between the old map of malaria and the later distribution of
multiple sclerosis (MS) first carried out in the USA (Part I) is continued in
Europe. The Italian 'dilemma' (Kurtzke), meaning the disappearance of the
north-south gradient in Italy by recent surveys, can be solved when considering
the dependence of malaria transmission in relation to the altitude. Further,
the high prevalence of MS in earlier times in Mississippi, Louisianna and in
the former province of Lucania in Italy can be explained by preceding epidemics
of malaria. Brickner's therapeutic trial with quinine in cases of MS patients
is reevaluated, and by this the Jarisch-Herxheimer reaction is shown to exist
in MS too. The possible significance of the old and rather forgotten
provocative methods for the diagnosis of latent malaria is discussed. Copyright
2001 Harcourt Publishers Ltd.

PMID: 11516219 [PubMed - in process]