Frank- 
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 Frank-

Donta is the only doc to publish this in a peer reviewed journal that I
know of!!! He is great. If only every LLMD did this!! Donta wrote in
article on other thread- re treatment- QUOTE as follows:

 With tetracycline or
augmented macrolide therapies, the duration of therapy appears to be an

important determinant of outcome. If chronic disease is present for
more than 1 to 3 years, it appears that 12 to 18 months of treatment is

needed to cure or control the disease, with longer duration of illness
requiring longer courses of therapy. Some patients with long-term
chronic disease appear to have limited or no response to treatment, the

reasons for which are unknown. The need for long courses of treatment
is not unique to Lyme disease. Other chronic infections such as
tuberculosis, leprosy, some fungal infections, and Q fever may require
months to years of antibiotic therapy for adequate resolution or
control of the disease.



Sat, 03 Nov 2007 08:12:01 GMT
 Frank-

Quote:
> With tetracycline or
> augmented macrolide therapies, the duration of therapy appears to be an

<snip>

Quote:
> Some patients with long-term chronic disease appear to have limited or no
> response to treatment, the
> reasons for which are unknown.

Unknown?
He must be joking.

Tetracycline has very poor {*filter*}-brain barrier penetration, of course people
with severe neuroborreliosis don't improve on "Dr. Tetracycline's" regimen
:(



Sat, 03 Nov 2007 08:55:22 GMT
 Frank-

Quote:

> Tetracycline has very poor {*filter*}-brain barrier penetration, of course people
> with severe neuroborreliosis don't improve on "Dr. Tetracycline's" regimen
> :(

Maybe the tetracycline does cross the bbb fairly when there is
inflammation of the bbb. But from all the scientific medical stuff I
have read, minocycline appears to be the most interesting
tetracycline-derivative to me. Or else doxycycline, which doctors will
prescribe much easier than minocycline.


Sat, 03 Nov 2007 09:20:24 GMT
 Frank-
I think the unknown is accurate.  I went downhill VERY quickly and
progressed worse than almostt anyone locally and I was on orals for a
year with very little effect and then IV for SO long months and months
without any effect- not until the 6th month of iV did I really start to
see effects!!! Stayed on 9 months. ANyway, why<>? Simplistic to say
persistent infection to me- is that it>? Or do I have a tick virus,
too>?  Or a different strain>? Or an inflammatory secondary process
interfering>? Or>? I don't know.  I didn't respond for so long I
thought I would die.  My hwole family thought I was going to die.
There are probably those who just *don't* ever respond and maybe he
meant those too.  Locally *everyone* has gotten better with treatment
except one guy who died and one guy who killed himself.  But with some
people it took over a year of IV!!! If I had been treated by Donta with
orals and not 9 omnths IV I would not have responded ever either!!! But
STILL, he has published this reputably and he is great!!!


Sat, 03 Nov 2007 10:38:27 GMT
 Frank-

Quote:
>I think the unknown is accurate.  I went downhill VERY quickly and
> progressed worse than almostt anyone locally and I was on orals for a
> year with very little effect and then IV for SO long months and months
> without any effect- not until the 6th month of iV did I really start to
> see effects!!! Stayed on 9 months. ANyway, why<>? Simplistic to say
> persistent infection to me- is that it>? Or do I have a tick virus,
> too>?  Or a different strain>? Or an inflammatory secondary process
> interfering>? Or>? I don't know.  I didn't respond for so long I
> thought I would die.  My hwole family thought I was going to die.
> There are probably those who just *don't* ever respond and maybe he
> meant those too.  Locally *everyone* has gotten better with treatment
> except one guy who died and one guy who killed himself.  But with some
> people it took over a year of IV!!! If I had been treated by Donta with
> orals and not 9 omnths IV I would not have responded ever either!!! But
> STILL, he has published this reputably and he is great!!!

I think people confuse things.
"Not responding" is nonsense.
You simply do not understand the exponentiality of the response curve.

The first two years, it will look like you "don't respond" but in fact
bacteria are killed in large numbers.
The reason you feel just as bad or even worse is that the bacteria
physically move through tissue when tissue levels change.

Only after a long time (can be YEARS), there is really strong improvement
and then the improvement will go faster and faster, that's normal, it's
alsways an exponential curve.



Sat, 03 Nov 2007 14:40:38 GMT
 Frank-
THat I also think is a possibility- that my perception of illness was
like the point in an hourglass where the sand moves through- it seems
to always have the same amount of sand in it- but then suddenly-
suddenly- there is less- and less- and then it is gone-


Sat, 03 Nov 2007 23:00:39 GMT
 
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