Brain Tissue Study Suggests Different Causes of MS 
Author Message
 Brain Tissue Study Suggests Different Causes of MS

".....Further research is required to confirm these results...."  

 This seems to be the conclusion in all FUNDED studies of everything !

georgia

Brain Tissue Study Suggests Different Causes of MS
National Multiple Sclerosis Society
June 9, 2000

Summary: An international team of researchers has reported results of a study
of nervous tissue samples taken from people experiencing active MS symptoms:

The team identified four distinct categories of MS based on the appearance and
analysis of brain lesions, or areas with myelin destruction;
The investigators suggest that what is called "MS" may be a group of similar
clinical diseases that have different causes, and that individuals with
different types of MS may require different therapies;
To follow up, the National MS Society has launched "The MS Lesion Project," a
five-year, $1.8 million international research project to correlate clinical
manifestations of MS and findings from MRI and brain tissue samples.
Details: A pathbreaking study of MS brain tissue conducted by an international
team of investigators has identified four distinct categories of multiple
sclerosis (MS), based on the appearance of brain lesions, suggesting there may
be several different mechanisms of myelin destruction in MS. The researchers
speculate that this may mean that what is called "MS" may be a group of similar
clinical diseases that have different causes, and that individuals with
different types of MS may require different therapies. The team, which includes
Hans Lassman, MD (University of Vienna, Austria), Wolfgang Bruck, MD (Humboldt
University, Berlin, Germany) and Claudia Lucchinetti, MD (Mayo Clinic,
Rochester, Minn.), reported its findings in the June issue of Annals of
Neurology.

Background: MS involves an immune-system attack against the insulating myelin
coating of nerve fibers in the brain and spinal cord. The attack can strip
myelin from the nerve fiber and leave a scarred lesion, or "plaque," that can
be seen on MRI scans. The clinical course and symptoms of MS within and between
individuals can be extremely variable, as is its effects on nervous tissue, as
seen by MRI and other scanning methods. In addition, people with MS differ in
their responses to therapy. Based on these and other observations, some
investigators have suggested that MS may not be one single disease but a
"syndrome" including a number of very similar diseases that all result in
myelin destruction. These are among the reasons the investigators undertook a
study looking at the physical appearance of actual MS lesions and the immune
forces at work in the lesions.

The Study: The researchers examined nervous tissue samples taken from people
experiencing active neurological symptoms. The samples came from 51 individuals
who had brain biopsies (a rare procedure sometimes necessary to exclude other
possible diseases) and from 32 individuals who had died in the midst of MS
flare-ups, or relapses. Most of the individuals sampled were in fairly early
stages of disease.

The team analyzed lesions in the brain tissues to determine what type of immune
cells and proteins were present, where and to what extent myelin was lost,
whether specific myelin proteins were absent or present, and whether
myelin-making cells (oligodendrocytes) appeared to be damaged or dead.

The investigators were able to classify lesions into four different patterns of
myelin destruction. Patterns I and II were similar, but not identical, in the
types of immune activity present, in the absence of all myelin proteins, in the
location of lesions near {*filter*} vessels, and in the presence of oligodendrocytes
in the center of lesions. Pattern III had similar immune activity but lesions
were not surrounding {*filter*} vessels, all but one type of myelin protein were
still present in damaged myelin, and there were no oligodendrocytes left in the
center of the lesions. Pattern IV, the most rare, showed immune activity in the
lesion, but myelin loss was associated with oligodendrocyte death in a rim of
adjacent, normal-appearing tissue, with almost a complete loss of
oligodendrocytes in active and inactive lesion areas.

Patterns of lesions were different between individuals, but for a given
indivdidual, multiple lesions had the same pattern. A distinct association
between lesion type and the clinical form of MS was not clear. Pattern I and II
lesions were found in people with all different clinical forms of MS. However,
pattern III lesions were mainly found in individuals who had had the disease
less than two months and pattern IV was found in only three individuals, all of
whom had the primary-progressive form of MS.

What the Study Means: These findings suggest, but do not prove, that processes
that lead to myelin destruction in MS may be different in distinct subgroups of
the disease. This raises the possibility that there may be different causes for
each subgroup, and also suggests that a therapy that may be effective in
individuals with one subgroup of disease may be ineffective, or even be
harmful, in individuals of a different subgroup.

Further research is required to confirm these results in a larger number of
tissue samples and to find non-invasive ways to detect what type of myelin
destruction any individual is experiencing, focusing on magnetic resonance
imaging techniques to understand if MRI characteristics match the actual lesion
pathology seen in tissues, and if both can be more closely associated with
clinical disease type.

To follow up on this important work, the National MS Society just launched "The
MS Lesion Project," a special Society-targeted investigation and the largest
study of its kind to correlate clinical manifestations of MS and findings from
MRI and brain tissue samples. The five-year, $1.8 million international
collaborative research project is being conducted by Dr. Claudia Lucchinetti at
the Mayo Clinic and the other collaborators in the current study.

From: Research Programs Department



Fri, 28 Feb 2003 05:24:49 GMT
 Brain Tissue Study Suggests Different Causes of MS

Quote:

> ".....Further research is required to confirm these results...."

>  This seems to be the conclusion in all FUNDED studies of everything !

> georgia

LOL  Yeah, but MS really sucks.

We had a school teacher MS patient
at the orthopedic/PT group I worked
for who had MS.  

*Everybody* loved her.
She was so sweet.

They carried her in for PT on a stretcher.

I remember her always smiling at us all, yet
she could do nothing for herself.

Kathleen

Quote:

> Brain Tissue Study Suggests Different Causes of MS
> National Multiple Sclerosis Society
> June 9, 2000

> Summary: An international team of researchers has reported results of a study
> of nervous tissue samples taken from people experiencing active MS symptoms:

> The team identified four distinct categories of MS based on the appearance and
> analysis of brain lesions, or areas with myelin destruction;
> The investigators suggest that what is called "MS" may be a group of similar
> clinical diseases that have different causes, and that individuals with
> different types of MS may require different therapies;
> To follow up, the National MS Society has launched "The MS Lesion Project," a
> five-year, $1.8 million international research project to correlate clinical
> manifestations of MS and findings from MRI and brain tissue samples.
> Details: A pathbreaking study of MS brain tissue conducted by an international
> team of investigators has identified four distinct categories of multiple
> sclerosis (MS), based on the appearance of brain lesions, suggesting there may
> be several different mechanisms of myelin destruction in MS. The researchers
> speculate that this may mean that what is called "MS" may be a group of similar
> clinical diseases that have different causes, and that individuals with
> different types of MS may require different therapies. The team, which includes
> Hans Lassman, MD (University of Vienna, Austria), Wolfgang Bruck, MD (Humboldt
> University, Berlin, Germany) and Claudia Lucchinetti, MD (Mayo Clinic,
> Rochester, Minn.), reported its findings in the June issue of Annals of
> Neurology.

> Background: MS involves an immune-system attack against the insulating myelin
> coating of nerve fibers in the brain and spinal cord. The attack can strip
> myelin from the nerve fiber and leave a scarred lesion, or "plaque," that can
> be seen on MRI scans. The clinical course and symptoms of MS within and between
> individuals can be extremely variable, as is its effects on nervous tissue, as
> seen by MRI and other scanning methods. In addition, people with MS differ in
> their responses to therapy. Based on these and other observations, some
> investigators have suggested that MS may not be one single disease but a
> "syndrome" including a number of very similar diseases that all result in
> myelin destruction. These are among the reasons the investigators undertook a
> study looking at the physical appearance of actual MS lesions and the immune
> forces at work in the lesions.

> The Study: The researchers examined nervous tissue samples taken from people
> experiencing active neurological symptoms. The samples came from 51 individuals
> who had brain biopsies (a rare procedure sometimes necessary to exclude other
> possible diseases) and from 32 individuals who had died in the midst of MS
> flare-ups, or relapses. Most of the individuals sampled were in fairly early
> stages of disease.

> The team analyzed lesions in the brain tissues to determine what type of immune
> cells and proteins were present, where and to what extent myelin was lost,
> whether specific myelin proteins were absent or present, and whether
> myelin-making cells (oligodendrocytes) appeared to be damaged or dead.

> The investigators were able to classify lesions into four different patterns of
> myelin destruction. Patterns I and II were similar, but not identical, in the
> types of immune activity present, in the absence of all myelin proteins, in the
> location of lesions near {*filter*} vessels, and in the presence of oligodendrocytes
> in the center of lesions. Pattern III had similar immune activity but lesions
> were not surrounding {*filter*} vessels, all but one type of myelin protein were
> still present in damaged myelin, and there were no oligodendrocytes left in the
> center of the lesions. Pattern IV, the most rare, showed immune activity in the
> lesion, but myelin loss was associated with oligodendrocyte death in a rim of
> adjacent, normal-appearing tissue, with almost a complete loss of
> oligodendrocytes in active and inactive lesion areas.

> Patterns of lesions were different between individuals, but for a given
> indivdidual, multiple lesions had the same pattern. A distinct association
> between lesion type and the clinical form of MS was not clear. Pattern I and II
> lesions were found in people with all different clinical forms of MS. However,
> pattern III lesions were mainly found in individuals who had had the disease
> less than two months and pattern IV was found in only three individuals, all of
> whom had the primary-progressive form of MS.

> What the Study Means: These findings suggest, but do not prove, that processes
> that lead to myelin destruction in MS may be different in distinct subgroups of
> the disease. This raises the possibility that there may be different causes for
> each subgroup, and also suggests that a therapy that may be effective in
> individuals with one subgroup of disease may be ineffective, or even be
> harmful, in individuals of a different subgroup.

> Further research is required to confirm these results in a larger number of
> tissue samples and to find non-invasive ways to detect what type of myelin
> destruction any individual is experiencing, focusing on magnetic resonance
> imaging techniques to understand if MRI characteristics match the actual lesion
> pathology seen in tissues, and if both can be more closely associated with
> clinical disease type.

> To follow up on this important work, the National MS Society just launched "The
> MS Lesion Project," a special Society-targeted investigation and the largest
> study of its kind to correlate clinical manifestations of MS and findings from
> MRI and brain tissue samples. The five-year, $1.8 million international
> collaborative research project is being conducted by Dr. Claudia Lucchinetti at
> the Mayo Clinic and the other collaborators in the current study.

> From: Research Programs Department



Fri, 28 Feb 2003 08:03:09 GMT
 
 [ 2 post ] 

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