Successful treatment of refractory type 1 autoimmune hepatitis 
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 Successful treatment of refractory type 1 autoimmune hepatitis

Subject: Successful treatment of refractory type 1 autoimmune hepatitis with
 methotrexate.

Quote:
> J Hepatol 1998 Dec;29(6):990-3

> Successful treatment of refractory type 1 autoimmune hepatitis with
> methotrexate.

> Burak KW, Urbanski SJ, Swain MG

> Department of Medicine, University of Calgary, Alberta, Canada.

> [Medline record in process]

> BACKGROUND/AIMS: Autoimmune hepatitis is a heterogeneous disorder that
> typically responds to glucocorticoids with or without azathioprine.
> Treatment options for patients not responding to standard therapy are
> limited. METHODS: We describe a 52-year-old female who presented with
> jaundice, marked elevation in liver enzymes, positive antinuclear
> antibody and a liver biopsy consistent with autoimmune hepatitis.
> Liver enzymes did not normalize with prednisone alone. When
> azathioprine was added, the disease flared. The patient refused
> cyclosporine. Methotrexate 7.5 mg po per week resulted in
> normalization of liver enzymes, improved liver histology, and has
> maintained remission with a steroid-sparing effect.
> RESULTS/CONCLUSION: In this patient methotrexate was used successfully
> to treat type 1 autoimmune hepatitis. This suggests that methotrexate
> may have a role in treatment of autoimmune hepatitis refractory to
> standard therapy.

> PMID: 9875647, UI: 99090825

As always do not substitute what you read in a post w/competent professional
medical advice which encompasses your unique medical condition


Mon, 25 Jun 2001 03:00:00 GMT
 
 [ 1 post ] 

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