cancer/autoimmunity axis? 
Author Message
 cancer/autoimmunity axis?

As cancer seems to develop when abnormal cells evolve to the point
where one cell escapes the onslaught from the immune system and so
continues to reproduce freely, and whereas autoimmune disease develops
because the immune system is hypersensitive to foreign proteins to the
point where it begins to attack the body's own cells which display
surface proteins which are similar to the exposed-to foreign protein,
is there epidemiologic evidence that people with autoimmune diseases
are less likely to develop cancer and vice versa?

In theory, there is no difference between theory and practice. In
practice there is.
Yogi Berra



Mon, 10 May 2004 22:58:02 GMT
 cancer/autoimmunity axis?


Quote:
> As cancer seems to develop when abnormal cells evolve to the point
> where one cell escapes the onslaught from the immune system and so
> continues to reproduce freely, and whereas autoimmune disease develops
> because the immune system is hypersensitive to foreign proteins to the
> point where it begins to attack the body's own cells which display
> surface proteins which are similar to the exposed-to foreign protein,
> is there epidemiologic evidence that people with autoimmune diseases
> are less likely to develop cancer and vice versa?

People with autoimmune disease may be MORE likely to get certain cancers
like lymphomas.
Quote:
> In theory, there is no difference between theory and practice. In
> practice there is.
> Yogi Berra



Tue, 11 May 2004 01:38:34 GMT
 cancer/autoimmunity axis?

Quote:



> > As cancer seems to develop when abnormal cells evolve to the point
> > where one cell escapes the onslaught from the immune system and so
> > continues to reproduce freely, and whereas autoimmune disease develops
> > because the immune system is hypersensitive to foreign proteins to the
> > point where it begins to attack the body's own cells which display
> > surface proteins which are similar to the exposed-to foreign protein,
> > is there epidemiologic evidence that people with autoimmune diseases
> > are less likely to develop cancer and vice versa?

> People with autoimmune disease may be MORE likely to get certain cancers
> like lymphomas.

Thank you, Steph.  Anything known about other cancers in this regard?


Tue, 11 May 2004 19:43:08 GMT
 cancer/autoimmunity axis?



Quote:


> > > As cancer seems to develop when abnormal cells evolve to the point
> > > where one cell escapes the onslaught from the immune system and so
> > > continues to reproduce freely, and whereas autoimmune disease develops
> > > because the immune system is hypersensitive to foreign proteins to the
> > > point where it begins to attack the body's own cells which display
> > > surface proteins which are similar to the exposed-to foreign protein,
> > > is there epidemiologic evidence that people with autoimmune diseases
> > > are less likely to develop cancer and vice versa?

> > People with autoimmune disease may be MORE likely to get certain cancers
> > like lymphomas.

> Thank you, Steph.  Anything known about other cancers in this regard?

As far as I'm aware, the only recognised relationship is with lymphomas.


Wed, 12 May 2004 01:11:37 GMT
 cancer/autoimmunity axis?

Quote:




> > > As cancer seems to develop when abnormal cells evolve to the point
> > > where one cell escapes the onslaught from the immune system and so
> > > continues to reproduce freely, and whereas autoimmune disease develops
> > > because the immune system is hypersensitive to foreign proteins to the
> > > point where it begins to attack the body's own cells which display
> > > surface proteins which are similar to the exposed-to foreign protein,
> > > is there epidemiologic evidence that people with autoimmune diseases
> > > are less likely to develop cancer and vice versa?

> > People with autoimmune disease may be MORE likely to get certain cancers
> > like lymphomas.

> Thank you, Steph.  Anything known about other cancers in this regard?

I guess the following shows what thoughts are these days on this:
Crit Rev Immunol 2000;20(6):433-50
Overwijk WW, Restifo NP.

Surgery Branch, National Cancer Institute, National Institutes of
Health, Bethesda, MD 20892-1502, USA.

It is increasingly clear that immunity to "self"-antigens may result
in tumor destruction in mouse and man. But which antigens should be
targeted with therapeutic cancer vaccines? In the case of melanoma,
recognition of melanocyte differentiation antigens (MDA) can be
associated with autoimmune depigmentation (vitiligo). We propose that
intersection of protein transport to melanosomes and endosomes allows
for the loading of MDA-derived peptides on MHC class II molecules,
resulting in the activation of MDA-specific CD4+ "helper" T cells that
aid the induction of melanoma-specific CD8+ T cells. Thus, the
immunogenicity of MDA may be a consequence of their unique cell
biology. Studies of MDA-based vaccines can provide new insight into
the development of more effective cancer vaccines.



Wed, 12 May 2004 05:37:19 GMT
 cancer/autoimmunity axis?

Quote:
> I guess the following shows what thoughts are these days on this:
> Crit Rev Immunol 2000;20(6):433-50
> Overwijk WW, Restifo NP.

not really.  if you are interested in vitiligo and melanoma vaccines you
should check out the current cancer research.  there is a posited increase
in leukemia.  but if you look at the arthritis research you'll see the
research is all over the place.....increase this, decrease that, who the
hell knows, who cares...


Wed, 12 May 2004 06:43:53 GMT
 cancer/autoimmunity axis?
Thu, 22 Nov 2001 09:38:34 -0800 in article


Quote:



>> As cancer seems to develop when abnormal cells evolve to the point
>> where one cell escapes the onslaught from the immune system and so
>> continues to reproduce freely, and whereas autoimmune disease develops
>> because the immune system is hypersensitive to foreign proteins to the
>> point where it begins to attack the body's own cells which display
>> surface proteins which are similar to the exposed-to foreign protein,
>> is there epidemiologic evidence that people with autoimmune diseases
>> are less likely to develop cancer and vice versa?

>People with autoimmune disease may be MORE likely to get certain cancers
>like lymphomas.

Perhaps also leukemia and lung cancer, especially people with arthritis.
But this may be treatment related, people with autoimmune diseases often
get immunosuppressive and other relatively toxic medication which may be
a factor.

People with arthritis seem to have a reduced risk of colon cancer. This
also could be treatment related, because arthritis patients frequently
get COX-inhibitors such as aspirin and other NSAIDS.

         -Matti Narkia



Thu, 27 May 2004 08:32:57 GMT
 cancer/autoimmunity axis?
Fri, 23 Nov 2001 09:11:37 -0800 in article


Quote:







>> > > As cancer seems to develop when abnormal cells evolve to the point
>> > > where one cell escapes the onslaught from the immune system and so
>> > > continues to reproduce freely, and whereas autoimmune disease develops
>> > > because the immune system is hypersensitive to foreign proteins to the
>> > > point where it begins to attack the body's own cells which display
>> > > surface proteins which are similar to the exposed-to foreign protein,
>> > > is there epidemiologic evidence that people with autoimmune diseases
>> > > are less likely to develop cancer and vice versa?

>> > People with autoimmune disease may be MORE likely to get certain cancers
>> > like lymphomas.

>> Thank you, Steph.  Anything known about other cancers in this regard?

>As far as I'm aware, the only recognised relationship is with lymphomas.

As I mentioned, there is also a reduced risk of colon cancer with
arthritis patients (possibly at least partly due to intake of aspirin
and other NSAIDs).

         -Matti Narkia



Thu, 27 May 2004 08:35:44 GMT
 
 [ 8 post ] 

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