Possible relief from bone cancer pain 
Author Message
 Possible relief from bone cancer pain

Possible relief from bone cancer pain
Bone cancer pain, due to bone destruction by cancerous cells, is common
among cancer patients and can have a devastating effect on their quality of
life. Most cancer-induced bone destruction is due to cells called
osteoclasts, which absorb bone material and are present in increased numbers
in cancerous bone. Existing treatments for bone cancer pain involve surgery,
radio and chemotherapy, and morphine. Now scientists at the University of
Minnesota may have discovered an alternative therapy.

Based on the knowledge that osteoclast formation is blocked by a molecule
called osteoprotegerin (OPG), Patrick Mantyh and colleagues injected OPG
into a mice femora which model bone cancer, and found that the treatment
eliminated destructive the osteoclasts from the site of the cancer and also
reduced bone destruction and pain. If OPG works the same way in humans, it
could enhance the quality of life of patients with bone cancer.

Steve Thompson and David Tonge of Guy's, King's & St. Thomas's School of
Medicine describe the results as "exciting" in an accompanying News & Views
article, and urge more study of why osteoclast activity causes pain.



Tue, 22 Oct 2002 03:00:00 GMT
 Possible relief from bone cancer pain


Quote:
> Possible relief from bone cancer pain
> Bone cancer pain, due to bone destruction by cancerous cells, is common
> among cancer patients and can have a devastating effect on their quality of
> life. Most cancer-induced bone destruction is due to cells called
> osteoclasts, which absorb bone material and are present in increased numbers
> in cancerous bone.

Another class of {*filter*} called "bisphosphinates" (including pamidronate and
clodrinate) have long been used for this purpose.

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Helpful links:

www.cancernet.nci.nih.gov
www.alphacancer.com
www.cancerfacts.com



Wed, 23 Oct 2002 03:00:00 GMT
 Possible relief from bone cancer pain


Quote:
> Possible relief from bone cancer pain
> Bone cancer pain, due to bone destruction by cancerous cells, is common
> among cancer patients and can have a devastating effect on their quality of
> life. Most cancer-induced bone destruction is due to cells called
> osteoclasts, which absorb bone material and are present in increased numbers
> in cancerous bone. Existing treatments for bone cancer pain involve surgery,
> radio and chemotherapy, and morphine. Now scientists at the University of
> Minnesota may have discovered an alternative therapy.

> Based on the knowledge that osteoclast formation is blocked by a molecule
> called osteoprotegerin (OPG), Patrick Mantyh and colleagues injected OPG
> into a mice femora which model bone cancer, and found that the treatment
> eliminated destructive the osteoclasts from the site of the cancer and also
> reduced bone destruction and pain. If OPG works the same way in humans, it
> could enhance the quality of life of patients with bone cancer.

> Steve Thompson and David Tonge of Guy's, King's & St. Thomas's School of
> Medicine describe the results as "exciting" in an accompanying News & Views
> article, and urge more study of why osteoclast activity causes pain.

And when the high tech stuff fails, there is always a fall-back to
radiotherapy. Works almost every time, without chemo or morphine.

JN



Wed, 30 Oct 2002 03:00:00 GMT
 
 [ 3 post ] 

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