Dear Madam/Sir,
 I appreciate it very much if you could let me know your idea about
operating of the case reported in follow.
 I should welcome to send you  more information if needed and look
forward to hearing from you.

M. Jalilian, MD.
Radiation onchologist,
Professor assistant,

Rosai-Dorfman Disease, Case Study, New case: November 2001

Patient's profile: 26ys, male, married

Chief Complain: Unconciousness after head trauma
               -Discovery of tumor by MRI
After surgery: Pathological findings include:Neoformation mass
consists of many Histiocyte-Lymphocyte and lasmacell;
some of them consists of Rassle body. The histiocytes have vesicular
nucleus with eosinophylic cytoplasm some of them have foamy cytoplasm.
There are lymphophagocytosis and plasmaphagocytosis in some of them.
In immunohistochemical dying S100 is severely positive and EMA, NSE,
Desmin are negative.

Pathological Diagnosis: Rosai-Dorfman Disease.  

In MRI study of the brain (May.14.2001):
 Multiple sections(axial, coronal & sagittal) were obtained through
multiple (T1 & dual echo, gradient echo T2) sequences.
Large solid lobulated mass of the neural cavity and ethmoid sinuses
with invasion of left orbit and  sphenoid sinus is seen, that is
accompanied by intra-cranial extension and presenting as an
extra-axial mass with pressure effect on base of frontal lobe.
   This mass is isointnese on T1 and hypointnese on T2 weighted
images.
Pressure effect on frontal horn is also noted. Other portions of the
brain are unremarkable.