Cancer, Prostate Cancer Treatment Poses Bone Risk -Study

Prostate Cancer Treatment Poses Bone Risk -Study

Author	Message
Roman Bystriany #1 / 30	Prostate Cancer Treatment Poses Bone Risk -Study http://www.*.com/ "Prostate Cancer Treatment Poses Bone Risk -Study", Reuters, January 12, 2005, Link: http://www..com/ ;jsessionid=U0G5SWQB40MLGCRBA... An increasingly popular prostate cancer treatment also makes bones brittle and may be responsible for over 3,000 fractures each year in the United States, researchers reported on Wednesday. The treatment calls for blocking the effects of the male hormone testosterone, either with {filter} or by castration. Until now, doctors have regarded the treatment as relatively harmless, Vahakn Shahinian, chief author of the new research, told Reuters. He said that given the new findings, doctors and patients should be aware of the risks of the therapy, which seems to slow the growth of prostate tumors, but may not always help patients live longer. The findings, reported in Thursday's New England Journal of Medicine, add another layer of complexity to the already-difficult question of how best to treat prostate cancer, which strikes 220,000 U.S. men each year. Sometimes a tumor is growing so slowly it's hard to know whether treatment is necessary. Neutralizing testosterone is one option. More than 88,000 men a year get the drug treatment, and the number has been "exploding," Shahinian said. But the Shahinian team, which studied the records of nearly 51,000 cancer patients, found 19.4 percent of men who survived at least five years after anti-testosterone therapy broke a bone. In other patients, the rate was 12.6 percent. "Our findings, along with those of smaller clinical series, underscore that such treatment is not benign" and there is no hard evidence it helps patients live longer, the researchers warned. They also said doctors should be testing whether {filter*} designed to prevent brittle bone disease can counteract the side effects of anti-testosterone treatment.
Mon, 02 Jul 2007 11:24:27 GMT

Verno #2 / 30	Prostate Cancer Treatment Poses Bone Risk -Study Hormone therapy has never offered the hope of a cure for those of us with prostate cancer, even though it prolongs the life of a few. On the other hand, chemotherapy does offer the hope of a cure. Why do many of us keep clinging to hormone therapy? I can understand this hormone therapy thing before taxotere was available, because there was nothing else, really, but now there is effective chemotherapy available. With all of the side effects of hormone therapy the grind might even be worse than chemotherapy, and when you are on hormone therapy you KNOW that you are still not cured. Not to mention the fact that once the PCa become refractory (to hormone therapy) it is much more difficult to control by chemotherapy. Of course, the doctors and the Big Pharma guys (who give kick backs to the doctors) want to sell you something, so they wont stop you from asking for it. Just my two cents worth. Vernon Quote: > http://www.*.com/ > "Prostate Cancer Treatment Poses Bone Risk -Study", Reuters, January > 12, 2005, > Link: http://www..com/ ;jsessionid=U0G5SWQB40MLGCRBA... Quote: > An increasingly popular prostate cancer treatment also makes bones > brittle and may be responsible for over 3,000 fractures each year in > the United States, researchers reported on Wednesday. > The treatment calls for blocking the effects of the male hormone > testosterone, either with {filter} or by castration. Until now, doctors > have regarded the treatment as relatively harmless, Vahakn Shahinian, > chief author of the new research, told Reuters. > He said that given the new findings, doctors and patients should be > aware of the risks of the therapy, which seems to slow the growth of > prostate tumors, but may not always help patients live longer. > The findings, reported in Thursday's New England Journal of Medicine, > add another layer of complexity to the already-difficult question of > how best to treat prostate cancer, which strikes 220,000 U.S. men each > year. > Sometimes a tumor is growing so slowly it's hard to know whether > treatment is necessary. > Neutralizing testosterone is one option. More than 88,000 men a year > get the drug treatment, and the number has been "exploding," Shahinian > said. > But the Shahinian team, which studied the records of nearly 51,000 > cancer patients, found 19.4 percent of men who survived at least five > years after anti-testosterone therapy broke a bone. In other patients, > the rate was 12.6 percent. > "Our findings, along with those of smaller clinical series, underscore > that such treatment is not benign" and there is no hard evidence it > helps patients live longer, the researchers warned. > They also said doctors should be testing whether {filter*} designed to > prevent brittle bone disease can counteract the side effects of > anti-testosterone treatment.
Mon, 02 Jul 2007 21:56:32 GMT

madi #3 / 30	Prostate Cancer Treatment Poses Bone Risk -Study Quote: > But the Shahinian team, which studied the records of nearly 51,000 > cancer patients, found 19.4 percent of men who survived at least five > years after anti-testosterone therapy broke a bone. In other patients, > the rate was 12.6 percent. Hmm so 6.8% difference, probably stat. signif though with that number of patients. Yes, we'll need prescribe tabs for osteoporosis, although I'm seeing more and more men declining anti-androgen therapy as the results of radiation treatment improve. -- madiba
Mon, 02 Jul 2007 22:10:33 GMT

Step #4 / 30	Prostate Cancer Treatment Poses Bone Risk -Study Quote: > Hormone therapy has never offered the hope of a cure for those of us with > prostate cancer, even though it prolongs the life of a few. On the other > hand, chemotherapy does offer the hope of a cure. Why do many of us keep > clinging to hormone therapy? There is not one jot of evidence that any chemotherapy can cure prostate cancer. Don't mix hope with fact.
Tue, 03 Jul 2007 08:21:33 GMT

Verno #5 / 30	Prostate Cancer Treatment Poses Bone Risk -Study Hi Steph Where did you get your facts from? Vernon Quote: > > Hormone therapy has never offered the hope of a cure for those of us with > > prostate cancer, even though it prolongs the life of a few. On the other > > hand, chemotherapy does offer the hope of a cure. Why do many of us keep > > clinging to hormone therapy? > There is not one jot of evidence that any chemotherapy can cure prostate > cancer. Don't mix hope with fact.
Tue, 03 Jul 2007 08:38:32 GMT

Lori Mille #6 / 30	Prostate Cancer Treatment Poses Bone Risk -Study Quote: > http://www.*.com/ > "Prostate Cancer Treatment Poses Bone Risk -Study", Reuters, January > 12, 2005, > Link: http://www..com/ ;jsessionid=U0G5SWQB40MLGCRBA... type=healthNews&storyID=7309981 Quote: > An increasingly popular prostate cancer treatment also makes bones > brittle and may be responsible for over 3,000 fractures each year in > the United States, researchers reported on Wednesday. > The treatment calls for blocking the effects of the male hormone > testosterone, either with {filter} or by castration. Until now, doctors > have regarded the treatment as relatively harmless, Vahakn Shahinian, > chief author of the new research, told Reuters. > He said that given the new findings, doctors and patients should be > aware of the risks of the therapy, which seems to slow the growth of > prostate tumors, but may not always help patients live longer. > The findings, reported in Thursday's New England Journal of Medicine, > add another layer of complexity to the already-difficult question of > how best to treat prostate cancer, which strikes 220,000 U.S. men each > year. > Sometimes a tumor is growing so slowly it's hard to know whether > treatment is necessary. > Neutralizing testosterone is one option. More than 88,000 men a year > get the drug treatment, and the number has been "exploding," Shahinian > said. > But the Shahinian team, which studied the records of nearly 51,000 > cancer patients, found 19.4 percent of men who survived at least five > years after anti-testosterone therapy broke a bone. In other patients, > the rate was 12.6 percent. > "Our findings, along with those of smaller clinical series, underscore > that such treatment is not benign" and there is no hard evidence it > helps patients live longer, the researchers warned. > They also said doctors should be testing whether {filter} designed to > prevent brittle bone disease can counteract the side effects of > anti-testosterone treatment. That is why Curt has been on monthy Zometa infusions for over a year now. Apparently the cost, $1500.00 is too high for many insurances to pay (bastards) so bone density loss is a problem. I would encourage all who can't get Zometa to fight their insurance companies to pay. -- Lori Devoted wife of Curtis mets to bone at age 40 PSA on diagnosis 675 (12/31/2003 lowest PSA 14 Failed HT in 9 mo on Radiation for pain now Chemo to start in 4-6 wks possible clinical trial of MEDI-522 (Qwk) along with Taxotere and Decadron plus Zometa (Q3wks) http://www.**.com/
Tue, 03 Jul 2007 11:29:44 GMT

ron #7 / 30	Prostate Cancer Treatment Poses Bone Risk -Study I've posted this before, but it may need repeating. Those using bisphosphantes should be aware of this...Ron ...and so bisphosphonates are now being widely used to treat the osteoporosis that ADT can cause. As with most treatments, there can be a downside to bisphosphonate usage. Users should be sure to notify their dentists / {filter}surgeons that they are using bisphosphonates. There is increasing evidence indicating that those using bisphosphonates, should they develop an {filter}bone infection, are prone to jaw necrosis. It is now being suggested that those on ADT forego {filter}surgery, if possible...Best wishes and good health, Ron Bisphosphanates and {filter}Cavity Avascular Bone Necrosis Cesar A. Migliorati Journal of Clinical Oncology, Vol 21, Issue 22 (November), 2003: 4253-4254 Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic Robert E. Marx, DDS Journal of {filter}and Maxillo{filter} Surgery, Volume 61 No. 9 September 2003 Osteonecrosis of the maxilla: an unusual complication of prolonged bisphosphonate therapy. a case report. B. Mehrotra, J. Fantasia, S. Nissel-Horowitz, S. Vinarsky, M. Sheth, S. Ruggiero; Long Island Jewish Medical Center, New Hyde Park, NY Proc Am Soc Clin Oncol 22: page 795, 2003 (abstr 3194) Bisphosphonates and avascular necrosis of the jaws. Carter GD, Goss AN. Aust Dent J. 2003 Dec;48(4):268.
Tue, 03 Jul 2007 11:39:19 GMT

I.P. Freel #8 / 30	Prostate Cancer Treatment Poses Bone Risk -Study Ask them what a broken hip costs them. State Farm once threatened to drop us after we had multiple windshield claims due to SW desert sandstorms. I reminded them how much we had paid in premiums on our homes and autos and toys and umbrella policies over the decades. "Oops; never mind", they said Apparently they can do simple arithmetic. I.P. Quote: > That is why Curt has been on monthy Zometa infusions for over a year now. > Apparently the cost, $1500.00 is too high for many insurances to pay > (bastards) so bone density loss is a problem. I would encourage all who > can't get Zometa to fight their insurance companies to pay.
Tue, 03 Jul 2007 12:18:29 GMT

I.P. Freel #9 / 30	Prostate Cancer Treatment Poses Bone Risk -Study It also needs stomach acid -- something GERD patients should be eliminating with meds -- to work, and is a type of NSAID, which gives many people ulcers or GI bleeding. I.P. Quote: > I've posted this before, but it may need repeating. Those using > bisphosphantes should be aware of this...Ron > ...and so bisphosphonates are now being widely used to treat the > osteoporosis that ADT can cause. As with most treatments, there can be > a downside to bisphosphonate usage. Users should be sure to notify > their dentists / {filter}surgeons that they are using bisphosphonates. > There is increasing evidence indicating that those using > bisphosphonates, should they develop an {filter}bone infection, are prone > to jaw necrosis. It is now being suggested that those on ADT forego > {filter}surgery, if possible...
Tue, 03 Jul 2007 12:21:14 GMT

Step #10 / 30	Prostate Cancer Treatment Poses Bone Risk -Study Quote: > Hi Steph > Where did you get your facts from? > Vernon My professional life
Tue, 03 Jul 2007 13:37:40 GMT

Verno #11 / 30	Prostate Cancer Treatment Poses Bone Risk -Study Hi Steph Then tell us about yourself and share with us some insights into the inadequacies of chemotherapy. Vernon Quote: > > Hi Steph > > Where did you get your facts from? > > Vernon > My professional life
Tue, 03 Jul 2007 21:15:53 GMT

Step #12 / 30	Prostate Cancer Treatment Poses Bone Risk -Study Quote: > Hi Steph > Then tell us about yourself and share with us some insights into the > inadequacies of chemotherapy. > Vernon Done it lots of times before, Vernon. Do a search, I can't repeat it every time someone asks. You might want to try to find a study which shows that chemotherapy has any impact on survival in prostate cancer. Good luck, because there isn't one. Even response rates are appalling
Wed, 04 Jul 2007 00:25:52 GMT

Verno #13 / 30	Prostate Cancer Treatment Poses Bone Risk -Study Hi Steph, and J Well I beg to differ. You just have to look at the recently concluded clinical trials, after which the FDA approved taxotere, to see that the taxotere/emcyt combo does a lot for the guys with hormone refractory PCa, and with others. Why would the FDA approve taxotere if it had shown no efficacy? I happened to have looked at several of the research papers that came out of that clinical trial. There is also Satraplatin that is used in Europe. I do look forward to your comments. Vernon Quote: > > Hi Steph > > Then tell us about yourself and share with us some insights into the > > inadequacies of chemotherapy. > > Vernon > Done it lots of times before, Vernon. > Do a search, I can't repeat it every time someone asks. > You might want to try to find a study which shows that chemotherapy has any > impact on survival in prostate cancer. Good luck, because there isn't one. > Even response rates are appalling
Wed, 04 Jul 2007 04:52:49 GMT

Step #14 / 30	Prostate Cancer Treatment Poses Bone Risk -Study Quote: > Hi Steph, and J > Well I beg to differ. > You just have to look at the recently concluded clinical trials, after > which > the FDA approved taxotere, to see that the taxotere/emcyt combo does a lot > for the guys with hormone refractory PCa, and with others. > Why would the FDA approve taxotere if it had shown no efficacy? I > happened to have looked at several of the research papers that came out of > that clinical trial. There is also Satraplatin that is used in Europe. > I do look forward to your comments. > Vernon Find me one which shows a survival advantage compared in a controlled fashion with best standard management. Or find me one which suggests someone has been cured. Chemotherapy, even with modern {filter}, may be a useful palliative treatment for very carefully selected patients with hormone refractory advanced prostate cancer, but for now, at least, prostate cancer is usefully treated with surgery, radiotherapy and hormones, and that's it. You don't really want me to get into a discussion of why FDA approval does not equate with efficacy or safety? VIOXX?
Wed, 04 Jul 2007 10:54:08 GMT

Verno #15 / 30	Prostate Cancer Treatment Poses Bone Risk -Study Hi Steph I guess the guys said the same things about testicular cancer before they were forced to reckon with the cisplatin and its progeny. Thanks. Vernon Quote: > > Hi Steph, and J > > Well I beg to differ. > > You just have to look at the recently concluded clinical trials, after > > which > > the FDA approved taxotere, to see that the taxotere/emcyt combo does a lot > > for the guys with hormone refractory PCa, and with others. > > Why would the FDA approve taxotere if it had shown no efficacy? I > > happened to have looked at several of the research papers that came out of > > that clinical trial. There is also Satraplatin that is used in Europe. > > I do look forward to your comments. > > Vernon > Find me one which shows a survival advantage compared in a controlled > fashion with best standard management. > Or find me one which suggests someone has been cured. > Chemotherapy, even with modern {filter}, may be a useful palliative treatment > for very carefully selected patients with hormone refractory advanced > prostate cancer, but for now, at least, prostate cancer is usefully treated > with surgery, radiotherapy and hormones, and that's it. > You don't really want me to get into a discussion of why FDA approval does > not equate with efficacy or safety? VIOXX?
Wed, 04 Jul 2007 12:13:13 GMT

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