Heridetary ALS 
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 Heridetary ALS

Can anyone supply me with information about heridetary ALS.
Are the symptoms or life expectancy any different than from
Sporadic ALS. Is there an average age of onset etc?.

Also, Of the unidentifiable form of heridetary ALS.
The %80, for which no gene has been identified.
Is this called FALS3 ?.

Any information would be greatly appreciated.

Yours Sincerely

Wed, 06 Aug 2003 22:06:45 GMT
 Heridetary ALS
I can give you a personal point of view as a Familial (hereditary)ALS
Our family has the mutant gene for ALS know as SOD1 in chromosome21. I
believe that Familial ALS patients with this variant have a slow
progression. With several family member affected, (living and passed), all
have survived between 10 and 20+ years beyond diagnosis. We all started with
limb onset and bulbar symptoms would generally be a factor in the late
There is a fairly technical comparison of "Sporadic" and "Hereditary" ALS at
the Washington University School of Medicine Neuromuscular Disease Center's
web site at:
This site might help you with your "FALS3" question, but it appears your 80%
ratio seems right if I'm reading the abstract correctly.
Hope this helps you with your investigations.
Al Pickens

Sun, 10 Aug 2003 14:28:09 GMT
 [ 2 post ] 

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