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Sheell
#1 / 12
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 Periostat-What's So Special?? I called my pharmacist to find out pricing for Periostat on my drug plan, and was shocked to find out all it is a common antibiotic called doxycyline. The only difference I was told is that it's a 20 milligram dose. It's also about $72 for 100 pills. Doxycyline is WAY cheaper than that and there are generic forms I think for even less. With the risk of sounding stupid, am I to understand that a company expects the
public to pay an astronomical price for a common drug just because it's in a
smaller dose? Wouldn't cutting a 50 milligram tablet in half do the same
thing??
I called the company to ask, and they indeed said that's all it was. Can
someone please clarify this, or tell me what I'm not getting here. i though
this was some sort of miracle drug that they had developed.
Thanks!
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| Tue, 31 Jul 2001 03:00:00 GMT |
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le huar
#2 / 12
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Periostat-What's So Special?? You pretty much have it straight. It is a marketing gimmick aimed at
people like you who want an alternative to the dreaded #15 blade.
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| Tue, 31 Jul 2001 03:00:00 GMT |
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Joel M. Eich
#3 / 12
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Periostat-What's So Special?? I agree! This might that be similar to prophy and "deep cleaning," whatever
that is. I guess its the opposite of a shallow cleaning or something.
Deep cleaning is the 50 mg dose while prophy is 20 mg. Some patients
call the dentist and ask, "Can I just get two 20 mg appointments back
to back and just pay for the 2 prophies instead of the 50 mg root
planing and scaling?
Cheers,
Joel
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Quote:
>I called my pharmacist to find out pricing for Periostat on my drug plan, and
>was shocked to find out all it is a common antibiotic called doxycyline. The
>only difference I was told is that it's a 20 milligram dose. It's also about
>$72 for 100 pills. Doxycyline is WAY cheaper than that and there are generic
>forms I think for even less.
>With the risk of sounding stupid, am I to understand that a company expects the
>public to pay an astronomical price for a common drug just because it's in a
>smaller dose? Wouldn't cutting a 50 milligram tablet in half do the same
>thing??
>I called the company to ask, and they indeed said that's all it was. Can
>someone please clarify this, or tell me what I'm not getting here. i though
>this was some sort of miracle drug that they had developed.
>Thanks!
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| Tue, 31 Jul 2001 03:00:00 GMT |
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Sheell
#4 / 12
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Periostat-What's So Special?? Yes, this marketing ply is rather strange. IS there any difference from taking Periodtat or breaking a 50 milligram dose of Doxycycline in half and taking that? What the drug is called and what price it is in irrelevant to me! What I do care about is whether 2 doses a day of 20 milligrams of Doxcycline does indeed help the pockets. I had read that it gave a much better attachemnt than either the Perio chip or Atrdox and when I called the company they said it was only about a 1.30mm or a 1.03mm attachment. The control group without had a .80 I think! Not much better than the Perio chip or Atridox. These are not the figures I had seen posted here and read, which said it fixed
the pockets at about 50% or something! Much more impressive than the chip or
gel it seemed on paper. Is it really???
WHAT gives with this?? Is it valuble or not? Does it replace surgery, and if
not can you at least postpone it while using this? Does it stop the disease
from progressing??
Thanks!
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| Tue, 31 Jul 2001 03:00:00 GMT |
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le huar
#5 / 12
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Periostat-What's So Special?? The dose of periostat that is being recommended is 20mg TWICE a day. Very close to the 50mg tablet already available, and already being used for 10 years for its ANTI-collagenase effect, albeit previously not approved as such. And if you read the prescribing info, you will see that many of the side effects of the 20mg patented/branded drug are due to its antibiotic nature. All the company did was get approval for a new strength of an old drug. They didn't modify its chemical structure one friggin' bit, for instance, to make it subantibiotic and only an anti-collagenase drug. They found an existing drug which had a side effect of being anti-collagenase and then found a dose that had a low antibiotic effect, spent a lot of lobby money on the FDA, hyped it to the lay media and Voila The Cure. It didn't help a whole lot as 50mg or 100mg. But it will make a lot of
money short term for Collagenex.
Good Luck.
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| Wed, 01 Aug 2001 03:00:00 GMT |
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NOUS
#6 / 12
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Periostat-What's So Special?? The dose of Doxicycline in the periostat pill is about 20 mg , which has no
antibacterial effect. however the purpes of the medication is to increase an
enzyme level (collagenase ) in your system ,that would slow down the
destruvtion of the supporting bone around your teeth. You DO NOT want to be on
an antibiotic for along perid of time and so peristat is the solution!!
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| Thu, 02 Aug 2001 03:00:00 GMT |
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DrCnBse
#7 / 12
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Periostat-What's So Special?? le huart wrote : Quote: >It didn't help a whole lot as 50mg or 100mg. But it will make a lot of
>money short term for Collagenex.
As you probably know from the latest JAPA, in fact at best, patients gained only ~0.5mm more with Periostat and initial therapy over scaling and root planing alone. Seems like an awful lot of money for so little return. BTW how do your measure a 1/2mm with your probes. To not even a silly mm longer,
Stan Goloskov
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| Thu, 02 Aug 2001 03:00:00 GMT |
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Sheell
#8 / 12
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Periostat-What's So Special?? What is the deal then with this, direct from their site: Clinical studies have shown that Periostat administered after SRP
improved clinical attachment level by up to 52 percent and reduced
pocket depth by as much as 67 percent compared to SRP plus placebo.
These benefits were observed as early as three months into the study and
were maintained over the nine-month period of the trial.
Those are stated above are most certainly better results then 0.5mm!!! Is the
above hype and the 0.5mm gain reality? What gives??
<<As you probably know from the latest
JAPA, in fact at best, patients gained
only ~0.5mm more with Periostat and
initial therapy over scaling >>
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| Thu, 02 Aug 2001 03:00:00 GMT |
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Joel M. Eich
#9 / 12
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Periostat-What's So Special?? Hi Shellah, I was confused by this too. Does it mean SRP reduces 0.5 mm. and
Periostat plus SRP reduces 1.0 mm? This is a nice percentage
reduction over SRP alone.
Cheers,
Joel
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Quote:
>What is the deal then with this, direct from their site: >Clinical studies have shown that Periostat administered after SRP >improved clinical attachment level by up to 52 percent and reduced >pocket depth by as much as 67 percent compared to SRP plus placebo. >These benefits were observed as early as three months into the study and >were maintained over the nine-month period of the trial. >Those are stated above are most certainly better results then 0.5mm!!! Is the >above hype and the 0.5mm gain reality? What gives?? ><<As you probably know from the latest >JAPA, in fact at best, patients gained >only ~0.5mm more with Periostat and >initial therapy over scaling >>
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| Thu, 02 Aug 2001 03:00:00 GMT |
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Joel M. Eich
#10 / 12
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Periostat-What's So Special?? Hi Stan, I stick the periodontal probe in the pocket. If I bend down, it looks
like its one more millimeter. If I stand on tip-toes, it looks like
its a millimeter less.
I was reluctant to mention this because I thought that I was missing
something!
Cheers,
Joel
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Quote:
>le huart wrote :
>>It didn't help a whole lot as 50mg or 100mg. But it will make a lot of
>>money short term for Collagenex.
>As you probably know from the latest
>JAPA, in fact at best, patients gained
>only ~0.5mm more with Periostat and
>initial therapy over scaling
>and root planing alone. Seems like an awful
>lot of money for so little return. BTW
>how do your measure a 1/2mm with your
>probes.
>To not even a silly mm longer,
>Stan Goloskov
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| Thu, 02 Aug 2001 03:00:00 GMT |
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le huar
#11 / 12
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Periostat-What's So Special?? I guess what they are saying is that if you have a change of 1 mm with S/RP, you can get 1.5mm total with the addition of collagenex. However, if you have the surgery you need, you will probably have a 3 to 4 mm change which may change the biota of the pocket to a symbiotic one that is compatible with health. However, the Collagenex people are smart and know that there are
hundreds of thousands of people who will BEG their dentists to prescribe
the new panacea for pyorrhea. And, after these dentists see no real
clinical evidence of change, the drug will go back to relative
obscurity.
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| Thu, 02 Aug 2001 03:00:00 GMT |
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Sheell
#12 / 12
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Periostat-What's So Special?? I wonder if there is any better pocket reduction with Atridox and Periostat together. My dentist wants to remove some of the bone I think if I have surgery. Is that necessary to reduce the pockets? Think he said osseous surgery. Is there anything new on the horizon that takes the place of surgery, where if
I can keep this in check I won't have to have it?
Thanks! You guys are great!
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| Fri, 03 Aug 2001 03:00:00 GMT |
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