> Here's a start ........... I do not know what other studies say .... I
> 'll look more later on today.

> DISCLAIMER ~ these are lab experiments and may have nothing to do with
> human beings.

> And these are huge amounts of fluoride!

> Joel

> ***

> Basic Clin Pharmacol Toxicol. 2004 Oct;95(4):162-5. Related Articles,
> Links

> The effect of tamoxifen and fluoride on bone mineral density,
> biomechanical properties and {*filter*} lipids in ovariectomized rats.

> Czerny B, Pawlik A, Juzyszyn Z, Mysliwiec Z.

> Department of Pharmacokinetics and Therapeutic Drug Monitoring,
> Pomeranian Medical University, Powstancow Wielkopolskich 72, PL-70-111
> Szczecin, Poland.

> The most important aspect of therapy with fluoride and tamoxifen
> concerns its influence on bone tissue and lipid metabolism. The aim of
> the study was to evaluate the effect of tamoxifen and natrium fluoride
> (NaF) on bone metabolism, biochemical properties and {*filter*} lipids
> levels in ovariectomized rats. The study was performed in Wistar rats
> divided into 5 subgroups: ovariectomized controls, rats treated with
> NaF 20 mg/kg/24 hr, rats treated with NaF 20 mg/kg/24 hr+tamoxifen 2
> mg/kg/24 hr, rats treated with NaF 20 mg/kg/24 hr plus tamoxifen 4
> mg/kg/24 hr, and sham-operated controls. In ovariectomized rats the
> increase of total cholesterol, low-density lipoproteins cholesterol
> (LDL-cholesterol) as well as the decrease of bone mineral content,
> bone mineral density and biomechanical properties was observed. The
> therapy with NaF increased the level of total cholesterol,
> LDL-cholesterol, triglycerides, bone mineral density, bone mineral
> content. In this group the decrease of bone strength and stiffness was
> observed. The administration of tamoxifen reduced the changes in
> plasma lipid levels, but did not improve the biomechanical properties
> of bone tissue.

> PMID: 15504151 [PubMed - in process