Cardiac Iron / validation of cardiac iron estimates by MRI 
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 Cardiac Iron / validation of cardiac iron estimates by MRI

Cardiac Iron Determines Cardiac T2*, T2, and T1 in the Gerbil Model of
Iron Cardiomyopathy.
Wood JC, Otto-Duessel M, Aguilar M, Nick H, Nelson MD, Coates TD,
Pollack H, Moats R
Circulation. 2005 Jul 18;

BACKGROUND: Transfusional therapy for thalassemia major and sickle cell
disease can lead to iron deposition and damage to the heart, liver, and
endocrine organs. Iron causes the MRI parameters T1, T2, and T2* to
shorten in these organs, which creates a potential mechanism for iron
quantification. However, because of the danger and variability of
cardiac biopsy, tissue validation of cardiac iron estimates by MRI has
not been performed. In this study, we demonstrate that iron produces
similar T1, T2, and T2* changes in the heart and liver using a gerbil
iron-overload model. METHODS AND RESULTS: Twelve gerbils underwent iron
dextran loading (200 mg . kg(-1) . wk(-1)) from 2 to 14 weeks; 5
age-matched controls were studied as well. Animals had in vivo
assessment of cardiac T2* and hepatic T2 and T2* and postmortem
assessment of cardiac and hepatic T1 and T2. Relaxation measurements
were performed in a clinical 1.5-T magnet and a 60-MHz nuclear magnetic
resonance relaxometer. Cardiac and liver iron concentrations rose
linearly with administered dose. Cardiac 1/T2*, 1/T2, and 1/T1 rose
linearly with cardiac iron concentration. Liver 1/T2*, 1/T2, and 1/T1
also rose linearly, proportional to hepatic iron concentration. Liver
and heart calibrations were similar on a dry-weight basis. CONCLUSIONS:
MRI measurements of cardiac T2 and T2* can be used to quantify cardiac
iron. The similarity of liver and cardiac iron calibration curves in
the gerbil suggests that extrapolation of human liver calibration
curves to heart may be a rational approximation in humans.

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Mon, 07 Jan 2008 02:46:25 GMT
 
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