Smoking Versus Bupropion 
Author Message
 Smoking Versus Bupropion

Sounds like a smoke ..

"AChRs as targets for antidepressants anti-{*filter*}ive compounds"

My work has shown nicotine lecithin lithium acetylcholine choline
seem
to be all 'standins' for each other as they all raise acetylcholine.

NOW maybe bupropion .. too ..

-----------------

Is the inhibition of nicotinic acetylcholine receptors
by bupropion involved in its clinical actions?
Arias HR
Department of Pharmaceutical Sciences, College of Pharmacy,
Midwestern University, Glendale, Arizona 85308, USA.

In this minireview we will focus on those molecular and
cellular mechanisms exerted by bupropion (BP), ultimately
leading to the antidepressant and anti-nicotinic properties
described for this molecule.
The main pharmacological mechanism is based on the fact
that BP induces the release as well as inhibits the reuptake
of neurotransmitters such as a dopamine (DA) and norepinephrine
(NE).
Additional mechanisms of action have been also determined.
For example, BP is a noncompetitive antagonist (NCA) of several
nicotinic acetylcholine receptors (AChRs).
Based on this evidence, the dual antidepressant and anti-nicotinic
activity of BP is currently considered to be mediated by its
stimulatory action on the DA and NE systems as well as its
inhibitory action on AChRs.
Considering the results obtained in the archetypical mouse muscle
AChR, a sequential mechanism can be hypothesized to explain the
inhibitory action of BP on neuronal AChRs: (1) BP first binds to
AChRs in the resting state, decreasing the probability of ion
channel opening, (2) the remnant fraction of open ion channels is
subsequently decreased by accelerating the desensitization
process, and (3), BP interacts with a binding domain located
between the serine (position 6') and valine (position 13') rings
that is shared with the NCA phencyclidine and other tricyclic
antidepressants.
This new evidence paves the way for further investigations using
AChRs as targets for the action of safer antidepressants and novel
anti-{*filter*}ive compounds.

Published 5 June 2009 in Int J Biochem Cell Biol.

Who loves ya.
Tom

Jesus Was A Vegetarian!
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Thu, 12 Jan 2012 12:43:42 GMT
 Smoking Versus Bupropion
"Sounds like a smoke ..

"AChRs as targets for antidepressants anti-{*filter*}ive compounds"

My work has shown nicotine lecithin lithium acetylcholine choline
seem
to be all 'standins' for each other as they all raise acetylcholine."

"My work"?  What self delusional silliness.

Any excuse for the fag sucking and huffing we see.  Brain damage seems a
result,

you don't have even a year one at university grasp of biochemistry and
you are so vain as to speak of "my work".  You show no understanding of
what acetylcholine is or its function beyond knowing it as a search
term.  Many things can raise and decrease it, you have found nothing.



Fri, 13 Jan 2012 00:00:10 GMT
 
 [ 2 post ] 

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