USC PK workshop on August 5th and 6th, in WASHINGTON, D.C. 
Author Message
 USC PK workshop on August 5th and 6th, in WASHINGTON, D.C.

Dear Colleague:

        The Laboratory of Applied Pharmacokinetics of the University of
Southern California School of Medicine is putting on another satellite
pharmacokinetic conference, this time in association with the annual
meeting of the American College of Clinical Pharmacy from August 7-9,
1995, on August 5th and 6th, in WASHINGTON, D.C. It is on "Population
PK/PD Modeling, Individualized Drug Therapy, and New 'Multiple Model'
Design of Drug Dosage". The emphasis this time is first on the research
and clinical aspects of Population Modeling itself, and then on clinical
applications. Sponsorship is being sought from the American and the
International Medical Informatics Associations (AMIA and IMIA). Postgraduate
education credit for pharmacists is being sought from the University of
Southern California School of Pharmacy.

WHERE?  WHEN?  Our conference will be held in the Nathan Hale Room in the
Sheraton-Washington Hotel, Washington, D.C., on Saturday and Sunday, August
5th and 6th, 1995.  One must arrange travel, hotel, and meal accommodations

        The conference is intended to increase the understanding of
Population Pharmacokinetic Modeling and its role in optimization of
clinical trials and practical drug therapy. The concepts and software to
implement them (the parametric USC*PACK clinical and iterative Bayesian
and the nonparametric NPEM2 programs) are intended for general use, with
special application to the optimal modeling of {*filter*} used in cardiovascular
and infectious disease, AIDS, cancer, transplant situations, psychiatric
illnesses, and for Phase 1-2 and 2-3 trials and concentration-controlled
clinical trials. Information obtained in this conference can also be
implemented on other software.

WHO IS IT FOR?  The conference is for physicians and pharmacists with a
working knowledge of pharmacokinetics (Vd, Kel, etc) to apply modern
parametric and nonparametric modeling concepts to the study of population
models. Methods to describe diffusion of antibiotics into simulated
endocardial vegetations or abscesses and to compute and plot bacterial
killing curves will also be discussed, and new "Multiple Model" (MM)
approaches to dosage regimens will be introduced. Applications to
Trimethoprim, Aminoglycosides, Vancomycin, Digoxin, and other {*filter*} will
also be discussed.

BRING YOUR NOTEBOOK!  For those of you who already have or who wish to
obtain a nonparametric population modeling program and relevant clinical
software for the purposes to which this workshop is devoted, and who wish
to bring it in their own laptop or notebook computers to the workshop, you
are invited to walk along with it to obtain further tutorial and hands-on

OBJECTIVES: After the conference, participants should be able to:
1) Define the concepts behind parametric and nonparametric population
modeling, 2) Understand the iterative Bayesian and nonparametric
NPEM2 population modeling programs, 3) Implement population modeling and
Bayesian adaptive control methods to introduce a new drug to the
marketplace with optimal strategies for its precise and safe use, 4)
Compute bacterial growth and killing curves and drug diffusion into
endocardial vegetations, and 5) Understand the application of Bayesian
Adaptive Control concepts to practical aspects of managing drug
therapy optimally for patients.

THE FACULTY are: Roger Jelliffe, M.D., Prof. of Medicine, USC School of
Medicine, Los Angeles, CA, Course Coordinator; Alan Forrest, Pharm.D.,
Director of Pharmacometrics and Biostatistics, Millard Fillmore
Hospital, Buffalo, NY, Pascal Maire, Pharm.D., Chief Pharmacist,
Hospital Antoine Charial, Lyon, France, and John Rodman, Pharm.D., Vice
Chairman, Pharmaceutical Department, St. Jude Children's Research
Hospital, Memphis, TN.

        Please call (213) 342-1300, or Fax us at (213) 342-1302 if you
have any questions.


                                                Roger W. Jelliffe, M.D.
                                                Professor of Medicine

Preliminary Program: "Population PK/PD Modeling, Individualized Drug
Therapy, and New 'Multiple Model' Design of Drug Dosage"

Day 1 - Saturday, August 5, 1995, WASHINGTON, D.C.
8:30 AM - Registration
9:00 AM - Welcome - Dr. Roger Jelliffe
9:05 AM - An Overview of Population Modeling - Dr. Jelliffe
9:15 AM - Linear and Nonlinear Models - Dr. Jelliffe
                PK Models, Diffusion Models, Effect Models
                Cell and Bacterial Growth and Kill Models
9:45 AM - Parametric Population Models - Dr. Alan Forrest, SUNY, Buffalo
                Naive Pooling, Standard Two Stage, NONMEM
10:15AM - The Iterative 2-Stage Bayesian Precedure - Dr. Alan Forrest

10:45 AM - Break

11:00 AM - Nonparametric Population Models - Dr. Jelliffe
                NP Maximum Likelihood
                NP Expectation - Maximization
                Their Relationship to the Separation Principle
                        and to Optimal Drug Regimens
11:30 AM - Parameterizing Population Models - Dr. Jelliffe
                Linking Parameters to Descriptors
                        Body Weight, Ideal Body Weight, and
                        Body Mass Index
                        Creatinine Clearance
                        Cardiac Output
12:00 Noon - Clinical and Research Issues in Population
                        Modeling - Dr. Jelliffe
                Evaluating Renal Function
                Determining the Assay Error Pattern and the
                        Weighting Scheme for Measurements
                When to Get Serum Levels: Optimal Sampling Schedules
                Modeling Environmental Errors in Dosage
                        Preparation and Administration

12:30 PM - Lunch

1:30 PM - Demonstration of the Nonparametric Population Modeling
                        Program - Dr. Jelliffe
2:15 PM - Modeling Antibiotic Combinations and Killing - Dr. Forrest
3:00 PM - "Multiple Model" Adaptive Control and Optimal Drug
                        Dosing - Dr. Jelliffe

3:30 PM - Break

3:45 PM - Applying "Multiple Model" Cencepts to Therapy with Suramin -
                        Dr. Alan Forrest

4:15 PM - Current Bayesian Modeling and Clinical Models of Drug
                        Diffusion - Dr. Jelliffe
4:40 PM - Modeling Pharmacologic Effects and Drug Binding to Effect
                        Sites - Dr. Jelliffe
5:00 PM - Modeling Bacterial Growth and Kill, and the Post-Antibiotic
                        effect - Dr. Jelliffe

5:30 PM - Adjourn

Day 2 - Sunday, August 6, 1995, WASHINGTON, D.C.
9:00 AM - Making a Population Model of Trimethoprim with NPEM2 - Dr. Jelliffe
9:15 AM - The Front part - an Iterative Bayesian Population
                        Modeler - Drs. Jelliffe and Forrest
                Selecting patient data file types
                Evaluating Bioavailability
                Parameterizing the Model: Choosing Volume,
                        1/V, Clearance, or Kel
                Entering the Assay Error Pattern Polynomial
                Selecting the Convergence Criterion and iterations
                Defining the first Bayesian prior
                Setting the Initial estimates for the parameter ranges
                Defining the ranges to pass to the nonparametric back part

9:45 AM - The Back part - the Nonparametric Population Modeler itself -
                        Drs. Jelliffe and Forrest
                Using the program the standard way - picking up data and
                       ranges from the front part
                Selecting the number of grid (support) points for the
                       initial joint probability density function (PDF)
                Choosing plot and print options
                Evaluating the Nonparametric Output
                        The log-likelihood function
                        The difference between a cycle likelihood
                                and the max
                        The means, modes, skewnesses,
                                kurtoses, and the percentiles
                        New Descriptors of Dispersion - the DF-50 and DF-95
                        The 2-D plots of the Marginal PDF's
                        The 3-D plots of pairs of Joint Marginal PDF's
                                Comparing these with covariances
                                and correlations
                        Summarizing the grid points and their probabilities
                        Linking Nonparametric models to Multiple Model
                                Adaptive Control
                        Evaluating the convergence - Absolute and normalized
                                convergence plots
10:30 AM - Break

10:45 AM - More Population Modeling - Drs. Jelliffe and Forrest
                The Front part - seeing the output and parameter files
                The back nonparametric part - seeing the output file
11:00 AM - Running the modeler without the front part - Dr. Jelliffe
                Recovering and continuing after a power failure, or
                               continuing a previous run
                Plotting results of a previous run
11:30 AM - Clinical Applications: Individualizing Cancer Chemotherapy
                in the Pediatric Patient - Dr. John Rodman, St. Jude Hospital
12:00 Noon - Clinical Applications: Digoxin - Dr. Jelliffe
                Planning the initial regimen. Controlling the
                               Peripheral Compartment
                An interesting patient with Atrial Fibrillation
                A patient with very high levels - why?

12:30 PM - Lunch

1:30 PM - Clinical Applications: Vancomycin - Dr. Maire
                Setting the trough goals. Planning the initial regimen
1:50 PM - Clinical Applications: Trimethoprim - Dr. Jelliffe
                Setting the goals for PCP pneumonia
2:10 PM - Clinical Applications: Lidocaine - Dr. Jelliffe
                Setting the serum goals: Planning the tapering infusion
2:30 PM - Clinical Applications: Theophylline - Dr. Jelliffe
                Setting the goals and planning the regimen:
                              regular and sustained release forms
3:00 PM - Clinical Applications: Amikacin - Dr. Maire
                Setting the goals: once daily or what?
                Modeling diffusion into vegetations or abscesses
                Effect models - occupation of toxic binding sites
                Modeling bacterial growth and kill, and post -
                             antibiotic effect.

3:30 PM - Break

3:45 PM - Once Daily Aminoglycoside Therapy - Pros and Cons -
                Drs. Jelliffe, Forrest, Maire, and Rodman
                Evaluating 80 q 8 versus 240 q 24 - 2 cases,
                             3 values of CCr
                Serum AUC, and AUC in a peripheral effect compartment
                Evaluating the relative benefit of nonlinear uptake
                General Discussion
4:45 PM - Adjourn

Registration Form

        I wish to register to attend the USC - ACCP - AMIA - IMIA
Symposium on "Population PK/PD Modeling, Individualized Drug Therapy,
and New 'Multiple Model' Design of Drug Dosage"  on August 5th and 6th,

($245.00. For members of ACCP, AMIA or IMIA, only $215.00)
This Registration is for the Symposium only.

                Total:        $________________

                Please make checks payable to the:

                        Laboratory of Applied Pharmacokinetics

                Name of Registrant_________________________________




                City, State,Zip____________________________________

                Phone (____)______________________

                Fax    (____)_______________________


                I am______ am not_______ a member of ACCP.
                I am______ am not_______ a member of AMIA.
                I am______ am not_______ a member of IMIA.

Please return this form, with your check, directly to:

                Roger W. Jelliffe, M.D.
                Laboratory of Applied Pharmacokinetics
                USC School of Medicine
                CSC 134-B
                2250 Alcazar Street
                Los Angeles, CA 90033

        Our phone is (213) 342-1300, and our Fax is (213)342-1302.

        Please register early. First come are first served. Registration
        is limited to the available spaces available.

        I would _____ would not _____ also like to receive information
        about the USC software.

        I heard about this conference from______mailing _____
        word of mouth_____electronic bulletin board  _____
        other (please specify)________________

Fri, 05 Dec 1997 03:00:00 GMT
 [ 1 post ] 

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