BREAKTHRU CANCER TREATMENT - Endostatin /Angiostatin Booklist 
Author Message
 BREAKTHRU CANCER TREATMENT - Endostatin /Angiostatin Booklist

CANCER, Endostatin, Angiostatin,Folkman

Endostatin /Angiostatin Booklist
EntreMed announced that Endostatin and a related drug, Angiostatin were
shown to have significant tumor suppression results in trials with mice. The
{*filter*} work by turning off the {*filter*} supply systems to targeted tumors.
Angiostatin and Endostatin proteins were discovered by Judah Folkman, a
Harvard University cancer researcher.
http://www.***.com/ ;lists  journal citations and
books relevant to understamding cancer and how these kind of {*filter*} may work.
---------------------------------------
other highlighted pages:
http://www.***.com/ ; HIGH QUALITY ART BOOKS: See what the art
masters have been up to.
http://www.***.com/
STIMULATIONS These
books are geared for the interested layperson. Some are written by
distinguised scientists. All are thought provoking (even for the
physicists).
http://www.***.com/ ;Microsoft VISUAL BASIC - The emerging
standard for rapid protoyping.
http://www.***.com/ ; The recommended books directory.



Mon, 23 Oct 2000 03:00:00 GMT
 BREAKTHRU CANCER TREATMENT - Endostatin /Angiostatin Booklist

This cannot be considered a breakthrough until human trials are done.

Even a PA-S knows that.

Joe



Tue, 24 Oct 2000 03:00:00 GMT
 BREAKTHRU CANCER TREATMENT - Endostatin /Angiostatin Booklist


Quote:
>This cannot be considered a breakthrough until human trials are done.

>Even a PA-S knows that.

But most cancer patients don't. When the news announces boldly
that a cure for cancer has been found, that's all they hear. They
don't always hear or understand the details about the various
phases of clinical trials that must follow. These people are
desparate for something - anything - that will save their lives.
If the news says a cure is found, how can any reasonable person
expect them to do anything but assume that there is now a
treatment for their disease. The whole episode has been extremely
cruel. Entremed and the collective media should hang their heads
in shame.


Tue, 24 Oct 2000 03:00:00 GMT
 BREAKTHRU CANCER TREATMENT - Endostatin /Angiostatin Booklist

Quote:

> But most cancer patients don't. When the news announces boldly
> that a cure for cancer has been found, that's all they hear.

SNIPPED

Quote:
> The whole episode has been extremely
> cruel. Entremed and the collective media should hang their heads
> in shame.

I agree.  I understand the company was inundated with calls from people
volunteering for human trials.

Did you see their stock skyrocket!!  Ulterior motive maybe??

--
Edward J. Mathes, RPA-C
Internal Medicine

---------------------------------------------------------------------------------------------------------

That is all very fine, but it won't do - anatomy, botany.
Nonsense, Sir! I know an old woman in Covent Garden who
understands botany better, and as for anatomy, my butcher
can dissect a joint full as well.  No, young man, all this
stuff: you must go to the bedside, it is there alone you can
learn disease..
  Thomas Sydenham (1624-89)
   Cromwellian physician, who was dubbed
           'the English Hippocrates'
----------------------------------------------------------------------------------------------------------



Wed, 25 Oct 2000 03:00:00 GMT
 BREAKTHRU CANCER TREATMENT - Endostatin /Angiostatin Booklist

On Sat, 09 May 1998 23:19:58 -0400, Ed Mathes

Quote:


>> But most cancer patients don't. When the news announces boldly
>> that a cure for cancer has been found, that's all they hear.

>SNIPPED

>> The whole episode has been extremely
>> cruel. Entremed and the collective media should hang their heads
>> in shame.

>I agree.  I understand the company was inundated with calls from people
>volunteering for human trials.

>Did you see their stock skyrocket!!  Ulterior motive maybe??

I will say this and you can come to your own conclusions. I am an
amateur researcher but I have spent considerable time on this
because I am heavily involved in cancer patient support. Many
patients have been deeply hurt by the process on hearing that a
cure exists for their disease only to learn later that it's a
hoax. I am a cancer patient myself.

 I believe the following to be true. Entremed is a company who
apparently has no product whatsoever. They have no source of
income beyond speculative investments which are used to pay for
the drug research research and for their roughly 50 employees.
Actually, Entremed doesn't own those {*filter*}, but they hold an
exclusive license from Boston Children's Hospital who holds the
patents. Entremed also apparently holds license for thalidomide,
another drug for which cancer research is being conducted. An
arrangement with Bristol-Myers helps fund the research on
Angiostatin and thalidomide. If I'm not mistaken, thalidomide is
the drug which caused such an uproar in Europe several years ago
when it was discovered that it caused birth defects (can anyone
confirm this for me?)

Several months ago Entremed was roundly criticised by some in the
medical community for making similar announcements. The claims at
the time were that the announcements were premature and unethical
and were intended only to attract investment income.

The president of Entremed provided several TV interviews and
numerous other press interviews on Monday. He knew at the time
about the New York Times article and the erroneous impression
given to the public. Although he carefully avoided lying, he made
no attempt to put things into proper perspective. His appearances
seemed to further fuel the fires.

The Nobel Laureate who was quoted in the original New York Times
article as saying that the {*filter*} would produce a cure in two
years denies that he said anything of the sort. He claims that he
said that human trials would begin within two years and then we'd
begin to learn whether we had a cure.

So, if Entremed was smart at all, it sold much of it's held stock
when the price jumped from it's pre-announcement value of $12 to
a high of around $80 before closing on Monday at around $51. I
don't know that they took advantage of it, but the opportunity
was there, and they made no reasonable effort to stop the fiasco.



Thu, 26 Oct 2000 03:00:00 GMT
 BREAKTHRU CANCER TREATMENT - Endostatin /Angiostatin Booklist

Quote:

>> The whole episode has been extremely
>> cruel. Entremed and the collective media should hang their heads
>> in shame.

>I agree.  I understand the company was inundated with calls from people
>volunteering for human trials.
>Did you see their stock skyrocket!!  Ulterior motive maybe??

I hear the story was broken originally by the New York Times.  By Gina
Kolata.  A person notorious for getting stories wrong, screwing things
up and generally being an idiot.  In my shy, retiring opinion.

                George M. Carter



Thu, 26 Oct 2000 03:00:00 GMT
 BREAKTHRU CANCER TREATMENT - Endostatin /Angiostatin Booklist


writes:

Quote:
> I believe the following to be true. Entremed is a company who
>apparently has no product whatsoever. They have no source of
>income beyond speculative investments which are used to pay for
>the drug research research and for their roughly 50 employees.
>Actually, Entremed doesn't own those {*filter*}, but they hold an
>exclusive license from Boston Children's Hospital who holds the
>patents. Entremed also apparently holds license for thalidomide,
>another drug for which cancer research is being conducted. An
>arrangement with Bristol-Myers helps fund the research on
>Angiostatin and thalidomide. If I'm not mistaken, thalidomide is
>the drug which caused such an uproar in Europe several years ago
>when it was discovered that it caused birth defects (can anyone
>confirm this for me?)

   Yes, it was found guilty of causing birth defects in 1960 and pulled
from the market in about early 1961.  Never did get licensed in the US,
as it was tangled up in beurocratic snafus in 1960 (they gave medals to
beurocrats for this, by which they learned that beurocratic snafus are
a Good Thing-- hence our present even more foot-draggy FDA).

    Thalidomide is immune modulator of a special kind, and has all
kinds of other uses (at present, mainly against Behcet's disease and as
an adjunct in leprosy).  It's available in places like Brazil, where
they have leprosy.  It will probably be back on the market in the US,
eventually.  With appropriate pregancy warnings, of course.

                                   Steve Harris, M.D.



Sat, 28 Oct 2000 03:00:00 GMT
 
 [ 7 post ] 

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