Journal Watch Sampler for Friday, Sept. 13 
Author Message
 Journal Watch Sampler for Friday, Sept. 13

  This is Journal Watch, a twice-weekly survey
of new medical research, produced by the
Massachusetts Medical Society, publishers
of The New England Journal of Medicine,
Health News, AIDS Clinical Care and Clinical
Care for Prostatic Diseases.
  Twice a week, our physician-editors summarize
clinical research from a group of about 50
journals. We post the top two summaries,
along with the complete table of contents,
to selected news groups in sci.med.
  To receive the complete complement of stories
*via email* please send your snail-mail address

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(the cost is $US60 a year).
                    *********
  Contents copyright 1996, Mass. Medical Society.

Journal Watch Summaries for Friday, September 13, 1996.

APPETITE SUPPRESSANTS AND PRIMARY PULMONARY
HYPERTENSION.
  N Engl J Med 1996 Aug 29; 335:609-16.

CHOLESTEROL TESTING FOR SIBLINGS OF PATIENTS WITH CHD.
  Arch Intern Med 1996 Aug 12/26; 156:1654-60.

TREATMENT OF GRAVES' HYPERTHYROIDISM.
  J Clin Endocrinol Metab 1996 Aug; 81:2986-93.

RISK FACTORS FOR NON-EPIDEMIC LEGIONELLA INFECTION.
  Arch Intern Med 1996 Aug 12/26; 156:1685-92.

GOOD OUTCOMES WITH RADICAL PROSTATECTOMY.
  JAMA 1996 Aug 28; 276:615-9.

GUIDELINES ISSUED ON USE OF CORONARY STENTS.
  J Am Coll Cardiol 1996 Sep; 28:782-94.

THE THERAPEUTIC YIELD OF LABORATORY TESTS.
  Am J Med 1996; 101:142-52.
DT.-960913.

AN.-1.
HL.-APPETITE SUPPRESSANTS AND PRIMARY PULMONARY
HYPERTENSION.
NS.-Earlier this year, the appetite suppressant
dexfenfluramine was approved for use in the U.S. Now a case-
control study from four European countries draws attention
to an association between appetite-suppressant {*filter*} and
primary pulmonary hypertension, a rare but often fatal
disease.
   Researchers identified 95 patients with primary pulmonary
hypertension and 355 controls matched for age, sex, and
primary physician. Previous use of appetite suppressants
(usually dexfenfluramine or fenfluramine) was reported by 32
percent of patients and 7 percent of controls. The odds
ratio for primary pulmonary hypertension associated with
these {*filter*} was 6.3, after adjustment for possible
confounders including body-mass index, smoking, systemic
hypertension, and use of {*filter*} or intravenous {*filter*}. The
odds ratio was 23.1 when the {*filter*} were used for more than 3
months.
   Comment: The evidence for an association between this
class of appetite suppressant {*filter*} and primary pulmonary
hypertension appears to be strong. We now need better data
on the absolute risk for primary pulmonary hypertension
among users of these {*filter*}. --AS Brett.
AU.-Abenhaim L; et al.
TI.-Appetite-suppressant {*filter*} and the risk of primary
pulmonary hypertension.
SO.-N Engl J Med 1996 Aug 29; 335:609-16.

AN.-2.
HL.-CHOLESTEROL TESTING FOR SIBLINGS OF PATIENTS WITH CHD.
NS.-While a family-based approach to cardiac risk
reduction seems appealing, data to support cholesterol
testing for siblings of patients with coronary heart disease
(CHD) are lacking. This study from Johns Hopkins University
examined the issue by testing 668 apparently healthy
siblings of patients with CHD; all participants were under
age 60.
   The investigators performed full cholesterol profiles, as
well as anthropometric measurements and assessment of other
cardiac risk factors. Owing to elevated total cholesterol
levels, 65 percent of all test subjects required fasting
cholesterol analysis, compared with 33 percent of a random
national sample. Thirty-five percent of the siblings were
candidates for dietary therapy, and 11 percent qualified for
cholesterol-lowering drug therapy, versus only 6 and 1
percent, respectively, of the national sample. Only about
half of those who qualified for dietary or drug therapy were
aware of their high cholesterol levels.
   Comment: Although there is controversy over the value of
screening the children of patients with premature CHD, this
study suggests that screening their siblings is worth
considering. --TL Schwenk.
AU.-Allen JK; et al.
TI.-Prevalence of hypercholesterolemia among siblings of
persons with premature coronary heart disease.
SO.-Arch Intern Med 1996 Aug 12/26; 156:1654-60.



Mon, 01 Mar 1999 03:00:00 GMT
 
 [ 1 post ] 

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