High IGF-1 and DHEAs, low testosterone - why? 
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 High IGF-1 and DHEAs, low testosterone - why?

Please help:

I'm a 32 year old male, 6' 155lb and mostly healthy. About 5 years ago
I was diagnosed with hashimoto's thyroiditis. I was prescribed 25mcg
of synthroid and I have been maintaining my TSH around 2 to 3 since
then. I can't get my TSH lower because I also have an electrical
problem with my heart.

Now just last year I was diagnosed with low testosterone (below 200).
My endocrinologist started me on testosterone injections. I decided to
not receive anymore injections in June because I got tired of having
injections (I couldn't see myself going to the doctor weekly for an
injection for the rest of my life) and I was hoping that my body would
somehow make the testosterone on its own.

That failed.. my testosterone went straight down and I tried to give
if a couple months to come back up, but it didn't budge.

So my doctor prescribed me testosterone gel. Now my testosterone is
around the middle range if not just a little under it.

I'm having a lot of problems including heart palpitations, acid
reflux, insomnia plus severe anxiety and panic attacks. I had to quit
exercising back in May of this year due to heart issues (I cannot run,
can walk ok). I've been offered beta blockers and I'm going to have an
echocardiogram next month. I'm not sure if suddenly stopping all
exercises back in May has something to do with my problems.

I was given a {*filter*} test last week and we got some strange results
back:

1. My DHEAs is 20% higher than the top of the reference range on the
lab.
2. My IGF-1 is also 20% higher than normal.
3. My TSH is 3.8
4. FSH and LH are low because I'm on a two tubes of androgel (yet
serum T is in the middle)
5. Cortisol is in the middle
Everything is is in range except for cholesterol. Bad is high and good
is low.

The only medicines I take are levoxyl 25mcg, aciphex for GERD, and 2
tubes of androgel (actually its off brand Testim gel). I'm considering
a beta blocker.

I have no headaches, no vision problems, prolactin is ok, psa is ok
(so far!), liver, kidney, etc. all ok. My endocrinologist cannot give
me a good answer as to why the DHEAs and IGF-1 are so high! I want
that IGF-1 to go down because I don't want cancer.

Why are DHEAs and IGF-1 so high - does this point to something else?

What {*filter*} tests should she check, what should be done!?? This is bad
when you have to suggest things to your own doctor.

Somebody please help me. My birthday is next week and all my wheels
are falling off. I really need help. I have to live a long time.. I
have a son to take care of and these doctors around here just don't
care unless you are a diabetic or have something easy to solve.



Tue, 27 Apr 2010 10:47:59 GMT
 High IGF-1 and DHEAs, low testosterone - why?
IGF-1 reference range: 115-307
My value: 324 (high)

DHEAs reference range: 120-520
My value: 572 (high)

Please note that my DHEAs has been increasing over the past year.
The first result I got was Aug 06 and it was 496
Then Nov 06 it was 516, then Jan 07 it was 520.
Now its 571. Going up, up and up.
It has been increasing since BEFORE my doctor started giving me the
testosterone replacement treatment.



Tue, 27 Apr 2010 11:33:55 GMT
 High IGF-1 and DHEAs, low testosterone - why?
I found this but I have no idea what it means (and I am not an "older
man" btw):

"Conversely, although testosterone replacement in older men increases
muscle anabolism and GH release, it also increases IGF-1 via increased
expression of intramuscular mRNA for IGF":

1. Morley J. Testosterone replacement in older men and women. J Gender
Specific Med.. 2001b;4:49-53.

2. Morley J. Androgens and aging. Maturitas.. 2001c;38:61-71.
[Medline]

3. Vermeulen A, Goemaere S, Kaufman J. Testosterone, body composition
and aging. J Endocrinol Investig.. 1999;22:110-116.[Medline]



Wed, 28 Apr 2010 03:44:47 GMT
 High IGF-1 and DHEAs, low testosterone - why?
I posted some general comments on another thead of yours.
Which I stand by but I need to add some comments.
Testosterone replacement by gels tends to be expensive
and only moderately successful. Often people run into
excess conversion of T into estradiol and this tends
to cause panic attacks and sub optimal response to
T replacement.

Further the drug Aciphex likely slows the metabolism of
estradiol such that can worsen estrogen problems.

As mentioned before, there are men's clinics and a subset
of physicians that specialize in male hormone replacement.
Many are not endos. Most endos aren't worth a "tinker's
damn" or worse when it come to hormone replacement.

I'll also add high dose inositol a vitamin-like material
can work wonders in some for panic attacks. A heaping
tablespoon of inositol powder can pretty much stop
a panic attack in some.  Beyond a Century has a
good price on the powder.

Reflux can be dealt with by sleeping on an incline
more incline than commonly suggested that is. And some
even benefit for additional acid from betaine HCL believe it or not.
I speak from personal experience.

The higher DHEA and IGF-1 aren't all bad.
First your DHEA isn't wildly high and could well be
considered normal in a younger person.
If your IGF-1 levels are up, I surely suggest you
start exercising to get it benefits.
I've the idea this may trace back to the thyroid or
the hormone used to replace it.
But I am a bit out of my depth but you are an
interesting problem.

I'll suggest you get an endocrinology text and become
a friend with the PUBMED website and the related endocrinology
journals.

Also as I suggested in the other posting, try the Yahoo
hypogonadal group they will have some good advice.



Wed, 28 Apr 2010 06:57:37 GMT
 High IGF-1 and DHEAs, low testosterone - why?

Quote:
> I found this but I have no idea what it means (and I am not an "older
> man" btw):

> "Conversely, although testosterone replacement in older men increases
> muscle anabolism and GH release, it also increases IGF-1 via increased
> expression of intramuscular mRNA for IGF":

> 1. Morley J. Testosterone replacement in older men and women. J Gender
> Specific Med.. 2001b;4:49-53.

> 2. Morley J. Androgens and aging. Maturitas.. 2001c;38:61-71.
> [Medline]

> 3. Vermeulen A, Goemaere S, Kaufman J. Testosterone, body composition
> and aging. J Endocrinol Investig.. 1999;22:110-116.[Medline]

I should hope so. Androgens work by raising IGF-1 levels in selected
tissues and human growth hormone works by raising IGF-1 levels
in all or nearly all tissues.

Given that you are on T replacement, you're for the purposes
this comment are older even if your 25 and if your 50 well
that is the middle of middle age which is older yet still. IMO



Wed, 28 Apr 2010 07:05:10 GMT
 
 [ 5 post ] 

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