Medical, Cystic Fibrosis

Cystic Fibrosis

Author	Message
Peter Benne #1 / 8	Cystic Fibrosis es Does anyone have additional information on the recent announcement of success- ful gene implantation in a lab environment? How about the artivles in CELL and NATURE, anyone read these yet? I'm always looking around the net for discussions about CF, gene therapy, and related topics, but I don't find much. Now that such advances are being mas made, it is becoming a real possibility that a genetic 'cure' for CF may be close at hand. What would be the next step in the research? Is there an animal lmodel for CF? Etc.......... Peter, future CF GENE THERAPY GUINEA OPIG
Tue, 16 Mar 1993 01:38:52 GMT

Barb Gardn #2 / 8	Cystic Fibrosis While someone is on the subject--I was adopted, and just found out last year that my real father is cystic fibrosis carrier. My half brother has the disease. Doe this automatically mean that I am a carrier, too, now? Is it true that the gene skips generations? Does the disease only occur when a certain genetic match occurs between a couple, like with the Rh factor? Any information would be appreciated. --Barb
Wed, 17 Mar 1993 00:44:36 GMT

Russell Shackelfo #3 / 8	Cystic Fibrosis Quote: > es > Does anyone have additional information on the recent announcement of success- > ful gene implantation in a lab environment? How about the artivles in CELL > and NATURE, anyone read these yet? > I'm always looking around the net for discussions about CF, gene therapy, and > related topics, but I don't find much. Now that such advances are being mas > made, it is becoming a real possibility that a genetic 'cure' for CF may be > close at hand. > What would be the next step in the research? Is there an animal lmodel for > CF? Etc.......... I posted a similar request a week or so ago. No takers. Dunno why. Re: animal models: last I heard, no, and that was one of the big stumbling blocks: they gotta do rat research and can't figure out how to create/simulate CF in animals.... russ -- Russell Shackelford The College of Computing Georgia Institute of Technology, Atlanta, GA, 30332
Tue, 16 Mar 1993 21:24:23 GMT

Russell Shackelfo #4 / 8	Cystic Fibrosis Quote: > While someone is on the subject--I was adopted, and just found out last year > that my real father is cystic fibrosis carrier. My half brother has the > disease. Doe this automatically mean that I am a carrier, too, now? Is it true > that the gene skips generations? Does the disease only occur when a certain > genetic match occurs between a couple, like with the Rh factor? to the best of my knowledge, CF is recessive. thus, you must get the genes from each parent. this means that a child of parents such that only one parent has the gene has 0% chance of having the disease and a 50% chance of being a carrier, while of child of parents such that both parents have th gene has a 25% chance of having the disease, a 75% chance of being a carrier, and a 25% chance of not being a carrier. that's all I know.... russ -- Russell Shackelford The College of Computing Georgia Institute of Technology, Atlanta, GA, 30332
Wed, 17 Mar 1993 04:46:25 GMT

747.. #5 / 8	Cystic Fibrosis Quote: >While someone is on the subject--I was adopted, and just found out last year >that my real father is cystic fibrosis carrier. My half brother has the >disease. Doe this automatically mean that I am a carrier, too, now? Is it true >that the gene skips generations? Does the disease only occur when a certain >genetic match occurs between a couple, like with the Rh factor? Cystic Fibrosis is believed to be an autosomal recessive genetic disorder. This means that you have to have two defective genes (one from each parent) in order to get the disease. Since your genetic father is a CF carrier, and you got one of his two genes at that locus, you have a 50% chance of having inherited his gene for cystic fibrosis. Your actual odds of being a carrier are probably slightly higher than that, since you could have gotten a CF gene from your genetic mother, but that's probably not going to have much of an effect on the odds. The background rate of CF carriers in the general (white) U.S. population is thought to be about 1 in 20. Therefore, if you were to have children with a white American (given no other genetic information) each child would have an approximately 1/4 chance of getting a CF gene from you and a 1/40 chance of getting a CF gene from the father, and so each child's risk of getting CF would be about 1/160. In fact, though, extra information often is available and since you have concerns about this, it would make sense to see a genetic counselor. Also, as testing for the CF gene becomes available, these crude risk calculations will become meaningless, since you will know for sure whether you have the gene or not. Let me add that I am not a geneticist, so if someone on the net thinks I've made a mistake in the calculations, please say so.
Wed, 17 Mar 1993 08:14:17 GMT

Gordon E. Ban #6 / 8	Cystic Fibrosis Quote: >> I'm always looking around the net for discussions about CF, gene therapy, and >> related topics, but I don't find much. Now that such advances are being mas >> made, it is becoming a real possibility that a genetic 'cure' for CF may be >> close at hand. >I posted a similar request a week or so ago. No takers. Dunno why. This net isn't read by thousands of cystic fibrosis researchers. If there are two of you, you can have some kind of discussion, no? All doctors don't know a whole lot about all diseases, especially those outside their specialties.
Wed, 17 Mar 1993 01:27:28 GMT

Gordon E. Ban #7 / 8	Cystic Fibrosis Quote: >While someone is on the subject--I was adopted, and just found out last year >that my real father is cystic fibrosis carrier. My half brother has the >disease. Doe this automatically mean that I am a carrier, too, now? Is it true >that the gene skips generations? Does the disease only occur when a certain >genetic match occurs between a couple, like with the Rh factor? I believe CF is an autosomal recessive disease. This explanation is based on that assumption. In order to display a trait that is recessive, you must inherit the gene from each parent. THus both parents are "carriers". Since neither parent was affected, each has one "good" and one "bad" gene. Each is capable of giving randomly a good gene or a bad gene to the offspring. Statistically then, 25% of the offspring will have a good gene from each parent (normal), 25% will have the good gene from father & bad from mother (carrier), 25% will have the good gene from mother & bad from father (carrier), 25% will have a bad gene from each parent (diseased). Thus the odds that you are a carrier are 2 to 1, given that you aren't diseased. In order to produce diseased offspring, you must mate with a male who also is a carrier. I don't know whether a test for carriers has been developed, but if it has, you and your spouse could be tested. If either one is not a carrier, there is no danger of your children being affected, although half of them statistically would be carriers if one of you is a carrier.
Wed, 17 Mar 1993 22:14:23 GMT

kathleen gag #8 / 8	Cystic Fibrosis the child of parents such that Quote: > both parents have the gene has a 25% chance of having the disease, a > 75% chance of being a carrier, and a 25% chance of not being a > carrier. Such a child would have a 50% chance of being a carrier.
Sun, 21 Mar 1993 10:03:12 GMT

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