Cholesterol lowering drugs 
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 Cholesterol lowering drugs

I heard that cholesterol lowering {*filter*} also lower the human immunity,
making the person weaker. Is this true?
Are there websites that discuss about the controversy of these {*filter*},
particularly against our immune system? Did the medical groups / drug
manufacturers try to hide this fact?
Is there any scientific reports or papers available that suggest the
above?
Thanks for info.


Sun, 30 Jul 2006 03:00:33 GMT
 Cholesterol lowering drugs

Quote:

> I heard that cholesterol lowering {*filter*} also lower the human immunity,
> making the person weaker. Is this true?
> Are there websites that discuss about the controversy of these {*filter*},
> particularly against our immune system? Did the medical groups / drug
> manufacturers try to hide this fact?
> Is there any scientific reports or papers available that suggest the
> above?
> Thanks for info.

This is the first time I've ever heard of this idea.  Statin {*filter*}
have been widely used for at least a decade and huge numbers of
people are currently on them with no apparent adverse effects.  I
did read of a very recent study that links the statin drug Lipitor
with memory loss; the link is still uncertain, although the brain
is composed of large amounts of cholesterol so that a cholesterol-
lowering drug may indeed have some effect on brain function.  As
for lowering immunity - statin {*filter*} are increasingly being given
to AIDS patients because some of the anti-HIV medications cause
extremely high cholesterol levels as a side-effect in some patients.
I think immune-system effects would be first noticed among this
group, so focus your research there.


Sun, 30 Jul 2006 10:37:24 GMT
 Cholesterol lowering drugs

Quote:
>I heard that cholesterol lowering {*filter*} also lower the human immunity,
>making the person weaker. Is this true?
>Are there websites that discuss about the controversy of these {*filter*},
>particularly against our immune system? Did the medical groups / drug
>manufacturers try to hide this fact?
>Is there any scientific reports or papers available that suggest the
>above?
>Thanks for info.

Interesting that you shold mention this, as I'm on a statin and have
noticed that problem.  This is the 1st time I've ever heard this
connection, but it makes sense to me.


Fri, 04 Aug 2006 06:48:47 GMT
 Cholesterol lowering drugs

Quote:
> I heard that cholesterol lowering {*filter*} also lower the human immunity,
> making the person weaker. Is this true?

There's no scientific evidence of it. I'd say the burden of proof is on
the person(s) making the claim.


Fri, 04 Aug 2006 10:15:06 GMT
 Cholesterol lowering drugs

Quote:

> Thanks for this post, I hadn't heard of it causing memory lose, also
> something me and the family have noticed.

The memory-loss connection was just reported by the media a week
or two ago.  So far, only Lipitor has been connected to it.
They aren't sure, but they suspect it has something to do with
the fact that the brain contains large amounts of cholesterol,
cholesterol being essential for proper neural functioning.  They
believe that Lipitor may be reducing the brain's cholesterol,
thus interfering with proper functioning and causing the memory
loss.  Further studies are being conducted to see if the loss
is caused by the other statin {*filter*}.

Both my parents are on statins, my mother takes Lipitor and my
father takes Mevachor.  Sometimes I do wonder if they're
getting Alzheimers, as they seem to forget lots of things.
A TV show will come on and I'll remark that we just watched the
same exact episode a few weeks ago and my father insists he
hasn't seen it.  I'll recite the entire plot and sometimes he
will recall having seen it.  But they are also getting old (61),
so it may be natural memory loss.  But even if it is statin-
related, you have to weigh the memory loss with the {*filter*}'
benefits.  My father was a ticking time bomb for a heart attack
due to his high cholesterol level, now his doctor proclaims him
to be in relatively perfect health in that respect.  Same for
my mother.  And their diets still suck (meat, cheese, grease,
etc., just like mine).



Tue, 08 Aug 2006 03:10:13 GMT
 Cholesterol lowering drugs
On 2004-02-19 14:10:13 -0500, "Charles Manson"

Quote:

>> Thanks for this post, I hadn't heard of it causing memory lose, also
>> something me and the family have noticed.

Lots of people have memory impairment (and have had long before statins
even existed), but thanks to cardiovascular disease (our nation's
number one killer), many people die long before they become demented.
Thanks to statins and reduced cardiovascular mortality and morbidity,
more people may outlive heart disease long enough to become demented.
I'd hardly fault the statin for that. There are way too many other
variables in the equation to easily prove cause and effect.


Tue, 08 Aug 2006 07:17:08 GMT
 Cholesterol lowering drugs

Quote:


> There is no reason to take a
> drug for something you MIGHT get. If that were the case, you'd be
> taking hundreds of medications daily.

You're right, Chuck. You could stop smoking, eat a balanced, healthy
diet, exercise regularly, maintain a healthy body weight, etc. Even so,
some of these "healthy" folks would still have *preventable* heart
attacks. And how many people do you know who are *really* doing all of
the above? There are reasons why our life expectancy is increasing, and
believe me...it's not because people are taking better care of
themselves.


Tue, 08 Aug 2006 07:29:31 GMT
 Cholesterol lowering drugs

Quote:

> Yes the memory problem is probably lipitor. No high cholesterol is not
> a cause of heart disease in and of itself. Sorry but 61 is getting
> older, true, but so is 37. Think how many active heads of
> corporations, governments, countries and high performance athletes are
> 60. I am 61, my cholesterol is almost 12, in the British system (500
> American system) and I have NO heart disease. However, I did suffer
> muscle pain, wasting and atrophy, memory and language loss, transient
> global amnesia, learning difficulties, pancreatitis, joint pain and
> injuries, vision damage and more--all from which I have only partly
> recovered. I still have no cardiovascular disease. All the members of
> my family have very high cholesterol. There is no reason to take a
> drug for something you MIGHT get. If that were the case, you'd be
> taking hundreds of medications daily. Read here:

The cholesterol, "bad cholesterol," is not the actual cause of heart
attacks, it simply contributes to them by encouraging the buildup
of plaque in the arteries.  Your level of 500 sounds very dangerous,
I can't believe you're not on statins.

Something in the news a month or two ago was an experiment where
they fed a solution of synthetic "good" cholesterol intravenously
for a period of 5 weeks and the study participants actually
experienced a small, but significant, in arterial plaque deposits.

I think newer {*filter*} will soon be developed that will reduce bad
cholesterol, increase good cholesterol, and also remove existing
plaque from artery walls; all without the negative side-effects
including memory loss.

I expect to need Lipitor in the near future, if not already.  I
had a {*filter*} test last year but didn't go in for the results,
although the nurse who called me suggested that the cholesterol
and triglyceride numbers were extremely high.  As I have no
health insurance, I need to consider the $40 or so per month the
Lipitor costs (and that's if I split high-dose tablets), and
also the cost of doctor's visits and the regular {*filter*} tests.



Tue, 08 Aug 2006 07:57:01 GMT
 Cholesterol lowering drugs
On 2004-02-19 18:57:01 -0500, "Charles Manson"

Quote:
> As I have no
> health insurance, I need to consider the $40 or so per month the
> Lipitor costs (and that's if I split high-dose tablets), and
> also the cost of doctor's visits and the regular {*filter*} tests.

Consider Mevacor (lovastatin), now available in generic form, and
generally less expensive than Lipitor. Also, ask your doctor if you
would qualify for a drug company (in Lipitor's case, Pfizer) patient
assistance program. I'm sure your doctor will work with you on the lab
costs if necessary. It's not really all that costly anyway. An ALT (the
typical liver function test used to monitor statins) costs around $20,
and you'd only need it every six months or so if you're on a stable
statin dose.


Tue, 08 Aug 2006 08:07:15 GMT
 Cholesterol lowering drugs

Quote:


> > I heard that cholesterol lowering {*filter*} also lower the human immunity,
> > making the person weaker. Is this true?

> There's no scientific evidence of it. I'd say the burden of proof is on
> the person(s) making the claim.

Anon said: There's no scientific evidence of it.

Are you sure of that? There are several studies looking at their use
as immunosuppressants in organ transplants.

This is just one of 60 citations I found on Pub Med looking statins in
the context of their possible role as immunosuppressants. B'adant

Minerva Urol Nefrol. 2003 Jun;55(2):111-9.  Related Articles, Links  

Acute renal allograft rejections, a role for statins?

Holdaas H, Jardine A.

Department of Medicine, National Hospital, Oslo, Norway.

Acute rejection of kidney allografts during the first months following
transplantation is one of the most important risk factor for long-term
graft failure. Some small open studies have indicated that
3-hydroxy-3-methylglutaryl coenzyme A (HMG-Co-A), statins, might act
as immunosuppressive agents, and reduce acute rejection rates.
Moreover, the use of statin in transplant recipients is quite common,
despite no data from prospective large multi-centre studies are
available to demonstrate any beneficial effect for acute rejections or
long-term cardiovascular protection in this population. In this
overview, recent clinical and experimental data will be provided for
assessing statins as immunosuppressive agents. Although in vitro
studies have provided a theoretical basis for the use of statins as
immunosuppressive agents, more recent clinical placebo controlled
studies have failed to confirm the initial optimism of this effect of
statins.

Publication Types:
Review
Review, Tutorial

PMID: 12847415 [PubMed - indexed for MEDLINE]



Tue, 08 Aug 2006 12:54:38 GMT
 Cholesterol lowering drugs

Quote:
> Are you sure of that? There are several studies looking at their use
> as immunosuppressants in organ transplants.

And not a one that proves anything. Lots of studies "look at" lots of
things without proving them. If you can't read the medical literature
critically, you shouldn't be reading it at all.


Tue, 08 Aug 2006 22:23:26 GMT
 
 [ 13 post ] 

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