Cholesterol lowering drugs
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anir #1 / 13
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 Cholesterol lowering drugs
I heard that cholesterol lowering {*filter*} also lower the human immunity, making the person weaker. Is this true? Are there websites that discuss about the controversy of these {*filter*}, particularly against our immune system? Did the medical groups / drug manufacturers try to hide this fact? Is there any scientific reports or papers available that suggest the above? Thanks for info.
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Sun, 30 Jul 2006 03:00:33 GMT |
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Charles Manso #2 / 13
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 Cholesterol lowering drugs
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> I heard that cholesterol lowering {*filter*} also lower the human immunity, > making the person weaker. Is this true? > Are there websites that discuss about the controversy of these {*filter*}, > particularly against our immune system? Did the medical groups / drug > manufacturers try to hide this fact? > Is there any scientific reports or papers available that suggest the > above? > Thanks for info.
This is the first time I've ever heard of this idea. Statin {*filter*} have been widely used for at least a decade and huge numbers of people are currently on them with no apparent adverse effects. I did read of a very recent study that links the statin drug Lipitor with memory loss; the link is still uncertain, although the brain is composed of large amounts of cholesterol so that a cholesterol- lowering drug may indeed have some effect on brain function. As for lowering immunity - statin {*filter*} are increasingly being given to AIDS patients because some of the anti-HIV medications cause extremely high cholesterol levels as a side-effect in some patients. I think immune-system effects would be first noticed among this group, so focus your research there.
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Sun, 30 Jul 2006 10:37:24 GMT |
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Basil Fawlt #3 / 13
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 Cholesterol lowering drugs
Quote: >I heard that cholesterol lowering {*filter*} also lower the human immunity, >making the person weaker. Is this true? >Are there websites that discuss about the controversy of these {*filter*}, >particularly against our immune system? Did the medical groups / drug >manufacturers try to hide this fact? >Is there any scientific reports or papers available that suggest the >above? >Thanks for info.
Interesting that you shold mention this, as I'm on a statin and have noticed that problem. This is the 1st time I've ever heard this connection, but it makes sense to me.
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Fri, 04 Aug 2006 06:48:47 GMT |
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anon #4 / 13
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 Cholesterol lowering drugs
Quote: > I heard that cholesterol lowering {*filter*} also lower the human immunity, > making the person weaker. Is this true?
There's no scientific evidence of it. I'd say the burden of proof is on the person(s) making the claim.
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Fri, 04 Aug 2006 10:15:06 GMT |
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Charles Manso #5 / 13
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 Cholesterol lowering drugs
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> Thanks for this post, I hadn't heard of it causing memory lose, also > something me and the family have noticed.
The memory-loss connection was just reported by the media a week or two ago. So far, only Lipitor has been connected to it. They aren't sure, but they suspect it has something to do with the fact that the brain contains large amounts of cholesterol, cholesterol being essential for proper neural functioning. They believe that Lipitor may be reducing the brain's cholesterol, thus interfering with proper functioning and causing the memory loss. Further studies are being conducted to see if the loss is caused by the other statin {*filter*}. Both my parents are on statins, my mother takes Lipitor and my father takes Mevachor. Sometimes I do wonder if they're getting Alzheimers, as they seem to forget lots of things. A TV show will come on and I'll remark that we just watched the same exact episode a few weeks ago and my father insists he hasn't seen it. I'll recite the entire plot and sometimes he will recall having seen it. But they are also getting old (61), so it may be natural memory loss. But even if it is statin- related, you have to weigh the memory loss with the {*filter*}' benefits. My father was a ticking time bomb for a heart attack due to his high cholesterol level, now his doctor proclaims him to be in relatively perfect health in that respect. Same for my mother. And their diets still suck (meat, cheese, grease, etc., just like mine).
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Tue, 08 Aug 2006 03:10:13 GMT |
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anon #6 / 13
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 Cholesterol lowering drugs
On 2004-02-19 14:10:13 -0500, "Charles Manson"
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>> Thanks for this post, I hadn't heard of it causing memory lose, also >> something me and the family have noticed.
Lots of people have memory impairment (and have had long before statins even existed), but thanks to cardiovascular disease (our nation's number one killer), many people die long before they become demented. Thanks to statins and reduced cardiovascular mortality and morbidity, more people may outlive heart disease long enough to become demented. I'd hardly fault the statin for that. There are way too many other variables in the equation to easily prove cause and effect.
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Tue, 08 Aug 2006 07:17:08 GMT |
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anon #7 / 13
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 Cholesterol lowering drugs
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> There is no reason to take a > drug for something you MIGHT get. If that were the case, you'd be > taking hundreds of medications daily.
You're right, Chuck. You could stop smoking, eat a balanced, healthy diet, exercise regularly, maintain a healthy body weight, etc. Even so, some of these "healthy" folks would still have *preventable* heart attacks. And how many people do you know who are *really* doing all of the above? There are reasons why our life expectancy is increasing, and believe me...it's not because people are taking better care of themselves.
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Tue, 08 Aug 2006 07:29:31 GMT |
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Charles Manso #8 / 13
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 Cholesterol lowering drugs
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> Yes the memory problem is probably lipitor. No high cholesterol is not > a cause of heart disease in and of itself. Sorry but 61 is getting > older, true, but so is 37. Think how many active heads of > corporations, governments, countries and high performance athletes are > 60. I am 61, my cholesterol is almost 12, in the British system (500 > American system) and I have NO heart disease. However, I did suffer > muscle pain, wasting and atrophy, memory and language loss, transient > global amnesia, learning difficulties, pancreatitis, joint pain and > injuries, vision damage and more--all from which I have only partly > recovered. I still have no cardiovascular disease. All the members of > my family have very high cholesterol. There is no reason to take a > drug for something you MIGHT get. If that were the case, you'd be > taking hundreds of medications daily. Read here:
The cholesterol, "bad cholesterol," is not the actual cause of heart attacks, it simply contributes to them by encouraging the buildup of plaque in the arteries. Your level of 500 sounds very dangerous, I can't believe you're not on statins. Something in the news a month or two ago was an experiment where they fed a solution of synthetic "good" cholesterol intravenously for a period of 5 weeks and the study participants actually experienced a small, but significant, in arterial plaque deposits. I think newer {*filter*} will soon be developed that will reduce bad cholesterol, increase good cholesterol, and also remove existing plaque from artery walls; all without the negative side-effects including memory loss. I expect to need Lipitor in the near future, if not already. I had a {*filter*} test last year but didn't go in for the results, although the nurse who called me suggested that the cholesterol and triglyceride numbers were extremely high. As I have no health insurance, I need to consider the $40 or so per month the Lipitor costs (and that's if I split high-dose tablets), and also the cost of doctor's visits and the regular {*filter*} tests.
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Tue, 08 Aug 2006 07:57:01 GMT |
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anon #9 / 13
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 Cholesterol lowering drugs
On 2004-02-19 18:57:01 -0500, "Charles Manson"
Quote: > As I have no > health insurance, I need to consider the $40 or so per month the > Lipitor costs (and that's if I split high-dose tablets), and > also the cost of doctor's visits and the regular {*filter*} tests.
Consider Mevacor (lovastatin), now available in generic form, and generally less expensive than Lipitor. Also, ask your doctor if you would qualify for a drug company (in Lipitor's case, Pfizer) patient assistance program. I'm sure your doctor will work with you on the lab costs if necessary. It's not really all that costly anyway. An ALT (the typical liver function test used to monitor statins) costs around $20, and you'd only need it every six months or so if you're on a stable statin dose.
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Tue, 08 Aug 2006 08:07:15 GMT |
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Ze #10 / 13
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 Cholesterol lowering drugs
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> > I heard that cholesterol lowering {*filter*} also lower the human immunity, > > making the person weaker. Is this true? > There's no scientific evidence of it. I'd say the burden of proof is on > the person(s) making the claim.
Anon said: There's no scientific evidence of it. Are you sure of that? There are several studies looking at their use as immunosuppressants in organ transplants. This is just one of 60 citations I found on Pub Med looking statins in the context of their possible role as immunosuppressants. B'adant Minerva Urol Nefrol. 2003 Jun;55(2):111-9. Related Articles, Links Acute renal allograft rejections, a role for statins? Holdaas H, Jardine A. Department of Medicine, National Hospital, Oslo, Norway.
Acute rejection of kidney allografts during the first months following transplantation is one of the most important risk factor for long-term graft failure. Some small open studies have indicated that 3-hydroxy-3-methylglutaryl coenzyme A (HMG-Co-A), statins, might act as immunosuppressive agents, and reduce acute rejection rates. Moreover, the use of statin in transplant recipients is quite common, despite no data from prospective large multi-centre studies are available to demonstrate any beneficial effect for acute rejections or long-term cardiovascular protection in this population. In this overview, recent clinical and experimental data will be provided for assessing statins as immunosuppressive agents. Although in vitro studies have provided a theoretical basis for the use of statins as immunosuppressive agents, more recent clinical placebo controlled studies have failed to confirm the initial optimism of this effect of statins. Publication Types: Review Review, Tutorial PMID: 12847415 [PubMed - indexed for MEDLINE]
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Tue, 08 Aug 2006 12:54:38 GMT |
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anon #11 / 13
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 Cholesterol lowering drugs
Quote: > Are you sure of that? There are several studies looking at their use > as immunosuppressants in organ transplants.
And not a one that proves anything. Lots of studies "look at" lots of things without proving them. If you can't read the medical literature critically, you shouldn't be reading it at all.
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Tue, 08 Aug 2006 22:23:26 GMT |
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