Seeking information on the drug "Ice" 
Author Message
 Seeking information on the drug "Ice"

     Greetings,

        I`m seeking information concerning the drug "Ice". If you
    could enlighten me concerning what the drug is a derivative of,
    the "high" it produces, the "signs of an abuser", and the treatment
    required to help those who request it then please drop me a line.

                                    Thanks,  



Fri, 19 Mar 1993 13:17:00 GMT
 Seeking information on the drug "Ice"

Quote:

>      Greetings,

>         I`m seeking information concerning the drug "Ice". If you
>     could enlighten me concerning what the drug is a derivative of,
>     the "high" it produces, the "signs of an abuser", and the treatment
>     required to help those who request it then please drop me a line.

        Ice is to Methamphetamine what Crack is to {*filter*}.  It is a
crystalline, smokable form.  Lasts a little longer than crack, and
apparently (if this is conceivably possible) makes you more paranoid
with continued use.

--
                Craig Werner   (future MD/PhD, 4.5 years down, 2.5 to go)

              (1935-14E Eastchester Rd., Bronx NY 10461, 212-931-2517)
                  "...if that's the hand you use, well, nevermind..."



Fri, 19 Mar 1993 00:33:00 GMT
 Seeking information on the drug "Ice"

Quote:

>    Ice is to Methamphetamine what Crack is to {*filter*}.  It is a
>crystalline, smokable form.  Lasts a little longer than crack, and
>apparently (if this is conceivably possible) makes you more paranoid
>with continued use.

Well, thanks for the analogy, but seriously,

Is there any chemical difference between "ice" and meth-amp?  Is
ordinary meth smokable, and the difference is in the marketing?  OR,
as with the coke-HCL --> coke change that changes the m.p. and decomp.
temp of coke, is there a real physical difference?  One would expect
inhalable meth to be more intense (faster risetime, higher peak concentration)
than via other routes, but is there a further difference?

Quote:
>            Craig Werner   (future MD/PhD, 4.5 years down, 2.5 to go)

Give us the facts straight, doc.

"Paranoia is awareness"
        -Alf

--
David A Honig



Fri, 19 Mar 1993 04:05:00 GMT
 Seeking information on the drug "Ice"
Ice is a smokable amphetamine.  It is a crack analog.  Studies
on {*filter*} vs. amphetamine have shown that {*filter*}s are often
unable to tell the difference between the "high" of one versus
the other when blinded as to what they are taking.  Medically,
the effects are similar, with the exception of the production of
cns vasculitis by amphetamines.  This has not yet been demonstrated
convincingly with {*filter*}.  The vasculitis usually leads to a stroke.


Fri, 19 Mar 1993 18:59:00 GMT
 Seeking information on the drug "Ice"

Quote:


>>         I`m seeking information concerning the drug "Ice".
>    Ice is to Methamphetamine what Crack is to {*filter*}.

I've heard that ice is "crystalline free base methamphetamine" a number
of times, mainly in the media.  The problem with this is that free base
methamphetamine is a liquid.  Below is a description of another
amphetamine-like drug that has also been called ice.  I could believe
the DEA labs might misrepresent the ice to make it easier to describe.
The information was sent to me in an email discussion of the same topic.

----

Here are some passages from an article titled "A Chemical and
Pharmacological Review of U4Euh/Intellex" by the New Age Chemist
(probably Shulgin) in volume 4 of Psychedelic Monographs & Essays
(available from Rosetta, PO Pox 4611, Berkeley, CA   94704 ).

"Chemical names: 4-methyl aminorex, 4-methyl-5-phenyl-2-amino-oxazoline,
4,5-dihydro-4-methyl-5-phenyl-oxazolamine.

(note: oxazoline appears to be the ring formed by
    -O-C(NH2)=N-CH(CH3)-CH-
     1 2      3 4       5

"Common names: U4Euh, Euphoria, Intellex, Ice, Verbosamine

"History:  4-methyl aminorex was first synthesized and its anorexigenic
and stimulant properties discovered by the research group of George Poos
at McNeil labs in Ft. Washington, PA, in the early 60's. [see J. Med. Chem,
6:266, 1963].  ... Attention was primarily directed at the anorexegenic
properties and the central effects were regarded as unwanted side effects.

"When a high production lab was discovered in Gainesville, Florida in
1986, the DEA investigated and the material has subsequently been
consigned to Schedule I under the emergency scheduling provision of the
Controlled Substance Act for a one year period beginning Oct. 15, 1987.

(i don't know what the final disposition of the drug was but it's not
hard to guess...)

"Chemistry: 4-methyl aminorex is prepared through an addition and
spontaneous cyclizing reaction involving PPA.

(another paper in the the same volume says it is synthesized from PPA
and cyanogen bromide)

The simplicity of the synthesis, the ready availability of precursors,
high yields, and the interesting central effects suggest that this
material will be around for a long time to come.

"Pharmacological profile:  ... Quantitatively, the experience is similar
to a long-lasting MDMA intoxication superimposed with methamphetamine,
with the added benefits of easy verbalization, free association, integration,
and elaboration of previous insights, making it a useful tool for
lecturers...  Nothing is know about the pharmacokinetics or pharmacodynamics
of 4-methyl aminorex.  The central effects (sympathomimetic) are believed
to be the result of increased release of catecholamines, and mimicking the
effects of these transmitters at receptor sites in the brainstem.



Fri, 19 Mar 1993 16:20:00 GMT
 Seeking information on the drug "Ice"

Quote:
>    [ice..]
>    the "signs of an abuser"

This isn't a flame, but I just thought I'd point out another use of
{*filter*}peaker. People who use {*filter*} are users, not abusers.

        Tim.
--

#include        <stdisclaim>
Why have coffee, when caffeine tastes this good?



Fri, 19 Mar 1993 10:27:00 GMT
 Seeking information on the drug "Ice"

Quote:

>>    the "signs of an abuser"
>This isn't a flame, but I just thought I'd point out another use of
>{*filter*}peaker. People who use {*filter*} are users, not abusers.

Well, it's accurate to say that some (most?) people who use {*filter*} are not
abusers, but some of them are.  Maybe the person wants to know the warning
signs of someone who is "taking too much".

For example:

Signs of LSD use:               Signs of LSD abuse:

Knowing smiles triggered                Totally wigged out
by certain Grateful Dead
lyrics

-Charles
"You get the point..."
"True, this is alt.flame but flames are supposed to contain a little more than
mindless insults. " - Muhanned Al-Nuaimy

#### This has nothing to do with Convex Computer Corporation -- obviously ####



Fri, 19 Mar 1993 10:55:00 GMT
 Seeking information on the drug "Ice"
Ice is the cristalline form of meth-amphetamine. It can be smoked and produces
a high comparable to crack cocain. Only, the high of 'ice' lasts up to 24
hours, vs 15 minutes for crack. Ice recently became popular in Hawaii, but
it's not new. Amphetamine was known before WWII, and drug users knew about ice
at least 10 years ago, because a book on 'How to make crystal meth' (=Ice) was
published in 1980. (I read most of this either in Time magazine or the
International Herald Tribune (can't remember), I'm no great expert).
Smoking a drug makes it hit much faster than taking a pill. Ice, or at least
meth-amphetamine gives about the same symptoms as cocain, but cocain is
stronger. In an OD you'll see: raised {*filter*} pressure, fast pulse, dilated
pupils, tremors and convulsions.

Ice gives more OD's than crack. Afterwards, Ice can give a hangover, with
severe depression, that can last up to two days.

A great problem is, that Ice can be made just about everywhere, you don't need
expensive and difficult to get cocain from South America. And it's not hard to
make.
  _
 / \__CH2__CH__NH_CH3 (meth-amphetamine) (Ice)
 \_/       |
          CH3    
(-- amphtamine -- methyl)

King Han Gan    Erasmus University Rotterdam
                School of Medicine and Health Sciences
                PO Box 1738 - 3000 DR Rotterdam
                The Netherlands
                (010) 476 1618



Fri, 19 Mar 1993 03:09:00 GMT
 Seeking information on the drug "Ice"


Fri, 19 Jun 1992 00:00:00 GMT
 Seeking information on the drug "Ice"

Quote:

>Ice is the cristalline form of meth-amphetamine.

The more popular unsmokable form of methamphetamine is known as "crystal
meth."  This hydrochloride salt of methamphetamine makes thin needle
crystals.  Assuming that "ice" really is methamphetamine, it would
be distinguished by the fact that it is the "free base" rather than
a more stable (and nonsmokable) crystaline salt.

I've looked in the Merck Index and the CRC Handbook for the melting point
of methamphetamine.  The Merck gives no information on free base
methamphetamine and lists only a melting point for the HCl salt.  The CRC
apparently doesn't have any information at all on methamphetamine (I
looked under *many* possible name variants).  The Merck Index doesn't
give the melting point of amphetamine, but does mention that the free base
"volatilizes slowly at room tempurature" with a boiling point of 200-203C
(amphetamine is a liquid).  I think methamphetamine would be a liquid as
well.

Quote:
>Ice recently became popular in Hawaii, but it's not new. Amphetamine was
>known before WWII, and drug users knew about ice at least 10 years ago,
>because a book on 'How to make crystal meth' (=Ice) was published in 1980.

The first journal report on methamphetamine synthesis appeared in 1929
(from ephedrine - Helv. Chim. Acta 12, 365, 1929 - in German of course; the
English Chem Abstract is good).  The first amphetamine reports came about
about the same time (JACS #53, 1875, 1931).  There is a wealth of other
(meth)amphetamine synthesis reports, from the classic reductive amination
with P-2-P to reduction of phenylalanine.  I've seen some underground
publications on (meth)ampehtamine synthesis, but they are of no more
value that the journal reports - mainly expansions on reductive amination
and how to manufacture P-2-P (schedule and restricted as a drug here - not
in England and other places).

The most popular underground synthesis has never been published, as far
as I can tell.  From what I've read from media reports, free lance
amphetamine chemists are producing methamphetamine from ephedrine (or
amphetamine from phenylpropanolamine, red phosphorous and hydroiodic
in a one step reaction.  Of course the mechanism isn't explained, but
it seems logical that it would be similar to a PCl5 reduction.  My
chemistry is rusty, but I presume the phosphorous provides the electrons
for the reduction and the iodine is involved in some intermediate state
replacing the {*filter*}.

Quote:
>It can be smoked and produces a high comparable to crack cocain. Only,
>the high of 'ice' lasts up to 24 hours, vs 15 minutes for crack.

You're stretching the effects of both of the {*filter*} in opposite directions.
Amphetamine certainly does have a longer action, but even taken orally
the effects have diminished significantly within 12 hours.  Enjoyable
amphetamine effects last a few hours.  The rush of {*filter*} is certainly
gone in 15 minutes, but the effects are still enjoyable for at least a
half an hour longer, and present for longer than that.

Quote:
>A great problem is, that Ice can be made just about everywhere, you don't need
>expensive and difficult to get cocain from South America. And it's not hard to
>make.

There are fairly tight controls on chemicals used to manufacture the
amphetamines.  Even chemicals are not directly controlled are watched
by the DEA.

Quote:
>King Han Gan    Erasmus University Rotterdam

I hope you didn't mind the arguments.  I really enjoy your postings.

--
Ray Dueland



Fri, 19 Mar 1993 03:40:00 GMT
 
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