
Iron stores / metabolic syndrome / insulin resistance
RESULTS-After excluding individuals with likely hemochromatosis, mean
serum
ferritin values in premenopausal women, postmenopausal women, and men
were
33.6, 93.4, and 139.9 g/l, respectively. Metabolic syndrome was more
common
in those with the highest compared with the lowest levels of serum
ferritin
in premenopausal women (14.9 vs. 6.4%, P = 0.002), postmenopausal women
(47.5 vs. 28.2%, P < 0.001), and men (27.3 vs. 13.8%, P < 0.001).
Insulin
resistance also increased across quartiles of serum ferritin for men
and
postmenopausal women and persisted after adjustment for age,
race/ethnicity,
C-reactive protein, smoking, {*filter*} intake, and BMI.
CONCLUSIONS-Elevated iron stores were positively associated with the
prevalence of the metabolic syndrome and with insulin resistance.
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