Risk of lowering cholesterol with diet and drugs. 
Author Message
 Risk of lowering cholesterol with diet and drugs.

   I recently read a Los Angeles Times article on the risk of lowering
cholesterol with diet and {*filter*}. It says that there is a growing body
of evidence that lowering cholesterol via {*filter*} and diet may indirectly
raise the the risk of certain types of {*filter*} death by producing person
-ality changes. These include anger, irritability, and increased risk
taking. It also says that lowering cholesterol in monkeys reduces levels
of the neurotransmitter serotonin, and that low levels of serotonin in
humans have been linked to an increased risk of aggressive behavior and
suicide.
   Has anyone else heard of this and do you know of any specific studies?
The article didn`t give any specific information about the studies.

Thanks,

Chester Massie

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Sun, 20 Nov 1994 03:36:11 GMT
 Risk of lowering cholesterol with diet and drugs.


Quote:
>   I recently read a Los Angeles Times article on the risk of lowering
>cholesterol with diet and {*filter*}. It says that there is a growing body
>of evidence that lowering cholesterol via {*filter*} and diet may indirectly
>raise the the risk of certain types of {*filter*} death by producing person
>-ality changes. These include anger, irritability, and increased risk
>taking. It also says that lowering cholesterol in monkeys reduces levels
>of the neurotransmitter serotonin, and that low levels of serotonin in
>humans have been linked to an increased risk of aggressive behavior and
>suicide.

This explains the behavior of militantly aggressive vegetarians, and
the dangerous risk-taking by Greenpeace workers.  :-)

Quote:
>   Has anyone else heard of this and do you know of any specific studies?
>The article didn`t give any specific information about the studies.

I would think that lowering cholesterol with a well-thought-out diet
would have vastly different effects than lowering it with {*filter*}.  The
Los Angeles Times may have generalized.  I, too, would be very interested
in seeing the specific studies.


Stolen Disclaimer: Any society that needs disclaimers has too many lawyers.



Sun, 20 Nov 1994 06:54:34 GMT
 Risk of lowering cholesterol with diet and drugs.


Quote:
>   I recently read a Los Angeles Times article on the risk of lowering
>cholesterol with diet and {*filter*}. It says that there is a growing body
>of evidence that lowering cholesterol via {*filter*} and diet may indirectly
>raise the the risk of certain types of {*filter*} death by producing person
>-ality changes.

There have been several studies of cholesterol lowering agents that
showed a benefit on deaths from heart disease, but no overall
benefit on mortality.  There are relatively few total deaths in these
studies, and a small excess number of {*filter*} or traumatic deaths
in the drug therapy groups is one of the reasons the studies didn't
find a reduction in total mortality.  A number of these deaths, though
are hard to link to behavior (like the study patient was killed in a
plane crash or struck by a drunk driver).  People aren't sure what to
make of the results, but it's fair to say that primary treatment
of elevated cholesterol has not been clearly shown to provide any
benefit in overall mortality.
--
David Rind



Sun, 20 Nov 1994 23:00:09 GMT
 Risk of lowering cholesterol with diet and drugs.

Quote:

>   I recently read a Los Angeles Times article on the risk of lowering
>cholesterol with diet and {*filter*}. It says that there is a growing body
>of evidence that lowering cholesterol via {*filter*} and diet may indirectly
>raise the the risk of certain types of {*filter*} death by producing person
>-ality changes. These include anger, irritability, and increased risk
>taking. It also says that lowering cholesterol in monkeys reduces levels
>of the neurotransmitter serotonin, and that low levels of serotonin in
>humans have been linked to an increased risk of aggressive behavior and
>suicide.
>   Has anyone else heard of this and do you know of any specific studies?
>The article didn`t give any specific information about the studies.

The hypothesized link between serotonin and and {*filter*} behavior and
suicide is mostly based on studies of the principal metabolite of
serontonin in the cerebrospinal fluid.  For example, suicide victims
were found to have low serotonin metabolite (5 HTIAA); suicide victims
dying {*filter*} deaths (e.g., gunshot) had lower levels than non{*filter*}
deaths (e.g., overdose).  Good reference:  Asberg M, Schalling D, et al:
Psychobiology of Suicide, Impulsivity, and Related Phenomena. In  
Meltzer HY: Psychopharmacology: The Third Generation of Progress, New York,
Raven Press, 1987.

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Sun, 20 Nov 1994 23:21:15 GMT
 Risk of lowering cholesterol with diet and drugs.

Quote:

>>   I recently read a Los Angeles Times article on the risk of lowering
>>cholesterol with diet and {*filter*}. It says that there is a growing body
>>of evidence that lowering cholesterol via {*filter*} and diet may indirectly
>>raise the the risk of certain types of {*filter*} death by producing person
>>-ality changes. These include anger, irritability, and increased risk
>>taking. It also says that lowering cholesterol in monkeys reduces levels
>>of the neurotransmitter serotonin, and that low levels of serotonin in
>>humans have been linked to an increased risk of aggressive behavior and
>>suicide.
>>   Has anyone else heard of this and do you know of any specific studies?

A clinical trial involving more than 1000 (high cholesterol) males was
made here in Finland. I don't have reference handy, but the results
were surprising, to such extent that physicians find it hard to accept
them. The group that was on medication as well as diet and lead a healthy
lifestyle had a much higher death rate than the control group with no
medication and less healthy lifestyle. Deaths in the medication group
included more accidents and suicides (suggesting higher stress due to
medical treatment and controlled lifestyle) than in the other group, as well as
deaths due to coronary disease. To avoid spreading inaccurate information
I'll post more on this when I get a hold of some reference.

/ep



Mon, 21 Nov 1994 15:02:23 GMT
 Risk of lowering cholesterol with diet and drugs.

Quote:

>   I recently read a Los Angeles Times article on the risk of lowering
>cholesterol with diet and {*filter*}. It says that there is a growing body
>of evidence that lowering cholesterol via {*filter*} and diet may indirectly
>raise the the risk of certain types of {*filter*} death by producing person

        There is a wide body of knowledge that
        argues 240 is a safer starting point to
        be concerned about cholesterol than all
        the anxiety 200 creates.

        Wm.

--


    21.19 N.LAT by 157.52 W.LONG          
    Fish on the Byte



Tue, 22 Nov 1994 07:30:09 GMT
 Risk of lowering cholesterol with diet and drugs.

Quote:
>>   Has anyone else heard of this and do you know of any specific studies?
>>The article didn`t give any specific information about the studies.

>I would think that lowering cholesterol with a well-thought-out diet
>would have vastly different effects than lowering it with {*filter*}.  The
>Los Angeles Times may have generalized.  I, too, would be very interested
>in seeing the specific studies.

Several thoughts:

Diet:
 Your standard diet will make people irritable just from lack of calories,
 if you have ever gotten into the middle of a flame war first thing in the
 morning before eating, the mind altering effects of insufficient sugar in
 the {*filter*} will be quite apparent several hours later when you go back
 and read what you just posted.

Cholesterol:
 I'm pretty sure the body can manufacture enough cholesterol for its needs,
 I doubt you could get short on it from diet. On the other hands {*filter*} might
 stop the body from manufacturing enough. Don't Monkeys generaly have a low
 cholesterol diet?

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Fri, 25 Nov 1994 13:43:58 GMT
 
 [ 7 post ] 

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