Calorie Restriction vs Exercise Fat Loss, Glucose, Hormones
Quote:
> > This will be of interest to as regards, calorie restriction, exercise
> > and various markers.
> > It's been well established that equivalent CR and Exercise will result
> > in the same degree of weight loss.
> > This report also measured additional parameters with some very
> > interesting findings.
> > No difference in fat loss.
> > Only CR reduced glucose and insulin and increase insulin sensitivity
> > CR uniquely effected the expression of 496 genes
> > Exercise only uniquely 20 genes
> > CR upregulated genes related to carb metabolism and glucose transport
> > On CR increased adiponectin (a hormone that does diabetics good)
> > Take home message: CR has unique benefits that cannot be duplicated by
> > exercise, but exercise still did good stuff.
> > My take from this and other reports: Cutting calories is as close to a
> > majic bullet that exist and it works for all the major ills.
> > (parkinson, cancer, alzhimiers).
> > Randy
> > Ref:
> > Differential Effects of Calorie Restriction and Exercise on the
> > Adipose
> > Transcriptome in Diet-Induced Obese Mice
> > Karrie E. Wheatley, Leticia M. Nogueira, Susan N. Perkins, and Stephen
> > D.
> > Hursting
> > Journal of Obesity; In press, Received 9 December 2010; Accepted 1
> > March
> > 2011
> > An Open Access Journal http://www.***.com/
> > ABSTRACT
> > The prevalence of obesity in the United States exceeds 30% in most
> > age
> > groups. Identifying effective antiobesity strategies and their
> > underlying
> > targets for breaking the link between adiposity, metabolic
> > dysregulation,
> > and increased risk for chronic disease is crucial for mitigating the
> > future
> > impact of obesity on health.
> > We hypothesized that obesity reversal by calorie restriction (CR)
> > versus
> > treadmill exercise (EX) would differentially modulate adipose gene
> > expression. Both interventions are known to result in comparable
> > reductions
> > in adiposity but exert differential effects on lean mass, hormones and
> > other
> > circulating factors, and cancer risk.
> > To test our hypothesis, 48 ovariectomized female C57BL/6 mice were
> > administered a high calorie, diet-induced obesity (DIO) regimen for 8
> > weeks,
> > then randomized to receive for 8 weeks either:1) a control (AIN-76A)
> > diet,
> > fed ad libitum (referred to as DIO control); 2) a 30% CR regimen; 3)
> > a
> > treadmill EX regimen (with AIN-76A diet fed ad libitum); or 4)
> > continuation
> > of the DIO diet.
> > Relative to the DIO control (which did not differ from the continuous
> > DIO
> > group, and thus was used as the DIO comparator for all analyses), both
> > CR
> > and EX reduced adiposity by 35-40% and serum leptin levels by 80%, but
> > only
> > CR increased adiponectin. In addition, CR (but not EX) decreased
> > fasting
> > glucose and insulin levels and increased insulin sensitivity. Gene
> > expression microarray analysis of visceral white adipose tissue
> > (VWAT)
> > revealed that 209 genes were responsive to both CR and EX, relative to
> > the
> > DIO group. However, CR uniquely altered expression of an additional
> > 496
> > genes, whereas only 20 were uniquely affected by EX. Of the genes
> > distinctly
> > responsive to CR, 17 relating to carbohydrate metabolism and glucose
> > transport were upregulated, including the insulin-responsive glucose
> > transporter 4, (Slc2a4) known as Glut4. Chromatin immunoprecipitation
> > assays
> > of the Glut4 promoter revealed that, relative to the DIO controls, CR
> > significantly increased histone 4 acetylation, consistent with
> > previous
> > reports from in vitro studies.
> > Taken together, these findings suggest that obesity reversal by CR
> > versus EX
> > results in many shared, but also many differential, changes in the
> > adipose
> > transcriptome. In addition, some of the effects of these antiobesity
> > interventions on VWAT gene expression and metabolism may result from
> > chromatin remodeling, as illustrated by CR's effect on histone
> > acetylation
> > of the GLUT4 promoter.
> Full paper available here: http://www.***.com/
> Highly recommended to tech types. Lots of introductory material and
> references.
> Good motivation of eating less, consistently
Smarter to hold to the right daily amount (32 oz) of
cooking.net">food because
fasting which is unsustainable is also eating less.
Yes, right amount (omer) control as Chris Malcolm is doing is much
more sophisticated and smarter:
http://www.***.com/
Be hungrier, which really is wonderfully healthier especially for
diabetics and other heart disease patients:
http://www.***.com/
We do this by weighing our meals per the http://www.***.com/
Approach to get our...
http://www.***.com/
and then...
http://www.***.com/
so that there will be...
http://www.***.com/
Being hungry is truly wonderful as proven by four lines of evidence:
Mathematical:
http://www.***.com/
Historical:
http://www.***.com/
Medical:
http://www.***.com/
Psychological:
http://www.***.com/
So that we really should http://www.***.com/
"wonderfully hungry" whenever we are greeted:
http://www.***.com/
http://www.***.com/
There is pure joy in being used by GOD to convince others:
http://www.***.com/
"A 2005 visit to an Atlanta cardiologist by the name of Andrew Chung
put me on some serious reality
I wasnt just chubby or husky, I am what they often call morbidly
obese. He explained that morbid obesity simply means that if something
happened to me that could be attiributed to weight and I were to end
up in the not breathing state
ok some call it DEAD
that a doctor could simply dismiss it as natural causes related to
weight more or less.
Ive been told I was a chunky fella a couple times, maybe even fat...
but not quite that harshly. Definitely made me think about a few
things, as much as I dislike scare tactics when it comes to health.
Well in the midst of the shock treatment, he also had me come to a
heart wellness seminar that he does on some Saturdays in Mableton.
Nice little get together, he has folks from the community come in and
discuss Tai Chi, exercises, testimonials, all kinds of good stuff.
Then he shows the movie SUPERSIZE ME to set up the pitch for his 2PD
Omer approach that he has his patients use to lose weight.
In a nutshell, in his view, HOW MUCH you eat is more of the issue than
WHAT you eat and portion is more important than any fat content or
calories.
I agree with this. This is why I have always been more successful on
more liquid diets (cabbage soup, slimfast, herbalife (tho dangerous))
than anything else. I wasnt eating the portions I was before that..."
Source:
http://www.***.com/
Love in the truth,
Andrew <><
--
Andrew B. Chung, MD/PhD
Board-certified Cardiologist
and Author of the 2PD-OMER Approach:
http://www.***.com/
