MAO inhibitors + Marijuana 
Author Message
 MAO inhibitors + Marijuana

        I've just taken my 1st MAO tablet (Phenelzine- yum yum)
 and I wonder if anyone out there has had experience with {*filter*}
 whilst on MAO inhibitors?
        If so, what's it like? I've heard MAOs are supposed to intensify
 anything that acts on the CNS.

PB.



Sun, 17 Oct 1993 16:42:50 GMT
 MAO inhibitors + Marijuana

Quote:

>         I've just taken my 1st MAO tablet (Phenelzine- yum yum)
>  and I wonder if anyone out there has had experience with {*filter*}
>  whilst on MAO inhibitors?
>         If so, what's it like? I've heard MAOs are supposed to intensify
>  anything that acts on the CNS.

Many of the substances discussed in this book are MAO inhibitors.  MAO
(monoamine oxidase) is an enzyme produced in the body, which breaks down
certain amines and renders them harmless and ineffective.  An MAO inhibitor
interferes with the protective enzyme and leaves the body vulnerable to
these amines.  A common substance such as tyramine, which is usually
metabolized with little or no phramalogical effect, may become dangerous in
the presence of an MAO inhibitor and cause headache, stiff neck,
cardiovascular difficulties, and even death.  MAO inhibitors may intensify
and prolong the effects of other {*filter*} (CNS depressants, narcotic
analgesics, anticholinergics, dibenzazepine antidepressants, etc.) by
interfering with their metabolism.  In the presence of an MAO inhibitor,
many substances which are ordinarily nonactive because of their swift
metabolism may become potent psychoactive {*filter*}.  This phenomenon may create
a new series of mind alterants.  However, because of the complex and
precarious variables involved, it is risky and foolish for anyone to
experiment with these possibilities on the nonprofessional level.
    . . . Among the matierials which may be dangerous in combination with
MAO inhibitors are sedatives, tranquilizers, antihistamines, narcotics, and
{*filter*} -- any of which can cause hypotensive crisis (severe {*filter*} pressure
drop); and ampheatamines (even diet pills), mescaline, asarone, nutmeg
(active doses), macromerine, ephedrine; oils of dill, parsley or wild
fennel; beer, wine, cocoa, aged cheeses and other tyrosine-containing foods
(tyrosine is converted into tyramine by bacteria in the bowel) -- any of
which can cause hypotensive or hypertensive (severe {*filter*} pressure rise)
crises.
                                                "Dangerous Combinations,"
                                                _Legal Highs,_ p. 61-2
                                                Adam Gottlieb

I've never done any experimenting with such things, so I can't relay effects
or personal feelings.  But I'd suggest at the very least that you use
caution.

-----
Max Pandaemonium  _ | _  Coming soon:  PARADIGM, to be located on the future

San Jose, CA        |          "Omnia quia sunt, lumina sunt."  Fnord.



Mon, 18 Oct 1993 02:34:32 GMT
 MAO inhibitors + Marijuana

Quote:

> I've just taken my 1st MAO tablet (Phenelzine- yum yum) and I wonder if
> anyone out there has had experience with {*filter*} whilst on MAO inhibitors?
> If so, what's it like? I've heard MAOs are supposed to intensify anything
> that acts on the CNS.

My experience is that there's no difference with {*filter*}, but a very
significant _decrease_ in the effectiveness of LSD.  What MAO inhibitors
do intensify is stimulants; these are very likely to be lethal.  Don't even
think about trying any stimulant stronger than coffee.

Tricyclics, in my experience, have a quite different effect; they do
potentiate MJ, and not at all pleasantly.

[ Somebody tell me if this gets outside the UK - it sometimes seems that
  we're read-only for this newsgroup. ]
--
--  Jack Campin   Computing Science Department, Glasgow University, 17 Lilybank
Gardens, Glasgow G12 8QQ, Scotland   041 339 8855 x6854 work  041 556 1878 home




Mon, 18 Oct 1993 19:44:15 GMT
 MAO inhibitors + Marijuana

Quote:

>[About MAO inhibitors' effects on some {*filter*}]

>_________

>jc> My experience is that there's no difference with {*filter*}, but a very
>jc> significant _decrease_ in the effectiveness of LSD.

>This makes sense. MAOIs stimulate the release of serotonin (among
>other things) whilst most of LSD's dramatic effects are due to its
>serotonin release inhibition (especially in the limbic and secondary
>visual brain areas).

No,no, no! It was first thought that serotonin inhibition was the causal factor
for halucinations from LSD use. But, subsequent studies seem to contest this
notion. Yes, LSD does cause serotonin inhibition, but other {*filter*} which block
the same receptors do *not* cause LSD-like effects. So, its back to the
drawing boards on that one. LSD is still quite a mystery drug regarding the
pathway of effect.

Quote:

>However, there is no indication that any cannabinoid does anything
>amazingly weird to the serotonergic systems; that makes it quite
>different from lsd.

        Cannabinoids seem to have a very different pathway of effect and as
any user of the two substances knows, the effects (while similar) are quite
different other than the obvious durration difference.

Quote:
>--
>    Bj

jim

ps -- please post here rather than sending me email. Thanks.



Thu, 21 Oct 1993 16:16:18 GMT
 MAO inhibitors + Marijuana

[About MAO inhibitors' effects on some {*filter*}]
_________

jc> My experience is that there's no difference with {*filter*}, but a very
jc> significant _decrease_ in the effectiveness of LSD.

This makes sense. MAOIs stimulate the release of serotonin (among
other things) whilst most of LSD's dramatic effects are due to its
serotonin release inhibition (especially in the limbic and secondary
visual brain areas).

However, there is no indication that any cannabinoid does anything
amazingly weird to the serotonergic systems; that makes it quite
different from lsd.

--
        Bj

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Wed, 20 Oct 1993 03:00:40 GMT
 
 [ 5 post ] 

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