REGISTRATION INFORMATION

                                  ISMB-95
                                  =======

                   The Third International Conference on
                 Intelligent Systems for Molecular Biology
                            July 16 - 19, 1995
                   Robinson College, Cambridge, England

     * FULL REGISTRATION MATERIAL AND LIST OF ACCEPTED PAPERS NOW ON WWW *

              ftp://ftp.icnet.uk/icrf-public/ismb/ismb95.html

              * Date for early registration discount 4th June *
                                                     --------

This file contains:

        Description of ISMB-95 Tutorials
        ASCII Text form of Registration Form
                        (See WWW for full registration pack)

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TUTORIALS

All tutorials will be offered on Sunday, July 16.  There will be parallel
sessions geared for introductory issues and advanced issues.  Tutorial costs
are 50 UKpounds for a single tutorial (65 UKpounds including lunch) and
95 UKpounds for two tutorials (including lunch).

INTRODUCTORY AM TUTORIALS (July 16, 1995, 10.00am - 1.00 pm):

T1      Molecular Biology for the Computer Scientist (Shankar Subramaniam)
        A description of the fundamentals of Molecular Biology, specifically
        aimed at the computer scientist. Topics to be covered include: the
        macromolecules of living systems,nucleic acid structure and
        function,protein structure and function, metabolism, energy flows,
        evolution and experimental methods in molecular biology.

T2      Intelligent Systems for the Molecular Biologist (Doug Brutlag)

        An overview of the intelligent system technologies that have been
        applied to molecular biology. Includes knowledge representation,
        machine learning, advanced database methods, knowledge-based
        simulation, and other techniques.  All topics will be taught using
        examples from everyday molecular biology research,and this tutorial
        is intended to be accessible to biologists without computational
        training.

ADVANCED AM TUTORIALS (July 16, 1995, 10.00am - 1.00 pm):

T3      Protein Structure Prediction (Sean O'Donoghue and Burkhard Rost)

        A review of the state of the art of computational techniques used
        in experimental determination of structure, and in the theoretical
        prediction of protein function and 1D, 2D, and 3D structure. Issues
        covered include: similarities and differences between the
        calculation methods used in deriving structures from X-ray
        crystallography and NMR spectroscopy; principles and methods
        relevant to closing the gap between known protein sequences and
        known structures; methods for testing and validating predicted
        structures.

T4      Machine Learning Approaches to Molecular Biology (Pierre Baldi)

        A broad overview of the applications of machine learning to
        problems in molecular biology. Discussion of statistical induction
        and modelling, and its relevance to these methods.  Discussion of
        the Bayesian framework, Cox-Jaynes axioms, hierarchical modelling,
        and model fitting and optimization. The latter portion of the
        tutorial will be dedicated to a detailed treatment of Hidden Markov
        Models and Stochastic Grammars.

INTRODUCTORY PM TUTORIALS (July 16, 1995, 2.15 pm - 5.45 pm):

T5      Linguistics of Biosequences (David Searls)

        Biological sequences viewed as strings in a language.  Formal
        language  theoretic aspects of DNA and protein sequences.  Review of
        proofs of the  positions of biologically relevant languages in the
        Chomsky  hierarchy, closure properties under biological operations,
        and the important role of syntactic ambiguity in genetic material.
        Applications of grammar-based approaches to biological sequences,
        including syntactic  pattern recognition and representation of
        inter-and intra-molecular  interactions in three-dimensional
        structure.

T6      Protein Evolution (Bill Pearson)

        This tutorial will present a review of our ability to look back
        through  evolutionary time using protein sequences and protein
        structures.   Doolittle's classification of ancient, middle-aged
        and modern proteins  will be used to examine different modes of
        protein evolution, looking  both at sequences and structures.  The
        evidence for and against an   informative role for exon structure
        will be discussed.  Strengths and  weaknesses of using similarity
        to infer homology, and exploration of the  confidence limits that
        can be placed on inferences of homology and  structural similarity
        will be a focus of the tutorial.  The statistics of  sequence
        similarity scores, information content and scoring matrices, and
        the strengths and weaknesses in current comparison methods will be
        summarized.

ADVANCED PM TUTORIALS (July 16, 1995, 2.15 pm - 5.45 pm):

T7      Computational Methods for Molecular Docking
                         (Gerhard Klebe,Thomas Lengauer)

        Chemical and computational issues in the inference of molecular
        docking. Types of chemical interactions, phases of the docking
        process, and enthalpic and entropic methods for evaluating docking
        potential.  Approaches to computing receptor-ligand interactions,
        including algorithms, data structures, computationally efficient
        models, and validation methods, presented from  an
        application-oriented viewpoint.

T8      Statistical Foundations of Multiple Sequence Alignment and
        Structure Prediction (Chip Lawrence)

        The significance of statistical methods for multiple sequence
        alignment, and their conceptual foundations.  Boltzman-like models
        of residue frequencies, permuted data likelihood, expectation
        maximization and Gibs sampling.  Refinements in the method to
        include multiple elements (gaps) and manage the flexibility vs.
        sensitivity tradeoff.  Incorporating structure into the
        calculation, including protein threading and stochastic context
        free grammars for RNA alignment.

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                         ISMB-95 REGISTRATION FORM

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        Are you:-       Full-time Student*  ......      Other   ......

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                        * Please include proof of full-time student status  

        ......  Tick here if you would like information about travel support

  TUTORIALS

        (select at most one tutorial from each column)

        AM      ......                  PM        ......

AM 16/7:                                PM 16/7:
T1:  Molecular Biology for the          T5:  Linguistics of Biosequences
         Computer Scientist             T6:  Protein Evolution
T2:  Intelligent Systems for the        T7:  Computational Methods for
         Molecular Biologist                    Molecular Docking
T3:  Protein Structure Prediction       T8:  Statistical Foundations of
T4:  Machine Learning Approaches                Multiple Sequence Alignment
        to Molecular Biology                    and Structure Prediction

        ONE                             TWO
50 UKpounds/$85/65ecu                   95 UKpounds/$155/125ecu
(or 65 UKpounds/$110/85ecu              (including lunch)
        including lunch)
                                                   UKpounds/$/ecu   ......

  CONFERENCE REGISTRATION

                        Early*                       Late

Full-time student*      125 UKpounds/$200/160ecu     150 UKpounds/$240/195ecu
Other                   150 UKpounds/$240/195ecu     175 UKpounds/$280/225ecu

                                                    UKpounds/$/ecu    ......

                        * Early registration = before 4 June 1995

      ACCOMMODATION/MEALS

(Pre-Tutorial:  15 July    Post-Conference:  19 July)

                Please specify date(s) ..............   UKpounds/$/ecu ......

Non-Residential

                Please specify date(s ) .............   UKpounds/$/ecu ......

                                                TOTAL   UKpounds/$/ecu ......

I enclose my cheque/money order (UKpounds, $US, ecus - please specify)
made payable to Imperial Cancer Research Fund (ISMB-95)

or debit my card:  Access/Visa/Amex/Diners Club (please specify)

Card No:                                        Expiry Date:    

Signed:                                         Date:

Please list:-

Any special dietary requirements        

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Any special accommodation requirements (eg twin room)  

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Whether wheelchair access is required  

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Please state if you would like to present a poster  at the
Open Poster Evening - to be held on Tuesday  July 18, 6.00pm - 7.30pm    

  Yes/No  

Return Registration Form with payment to:-
ISMB-95 Registration
c/o Dr C J Rawlings
Biomedical Informatics Unit
61 Lincoln's Inn Fields
LONDON  WC2A 3PX
Fax:  + 44 (0)171 269 3067