General anesthesia 
Author Message
 General anesthesia

What is the chemical formula for sodium pentathol,
and how is it made?

Thank you in advance.

__Richard Banks



Fri, 09 Feb 1996 12:10:52 GMT
 General anesthesia

Quote:

>What is the chemical formula for sodium pentathol,
>and how is it made?

Thiopental sodium, C11 H17 N2 O2 S Na

and don't even think about it.

  -- David Wright, Hitachi Computer Products (America), Inc.  Waltham, MA

     Hitachi's, though they are the opinions of all Right-Thinking People



Fri, 09 Feb 1996 18:01:28 GMT
 General anesthesia

I am writing a paper on sodium pentothal (Thiopental sodium,
C11 H17 N2 O2 S Na), and I have been unsuccessful in finding
information on how it is produced in industry.

If you can provide a description on how it is made or direct me
to sources that deal with this, it will be very much appreciated.

Thanks in advance.
 __Richard Banks



Sat, 10 Feb 1996 03:36:22 GMT
 General anesthesia

Quote:
(Richard Banks) writes:

> I am writing a paper on sodium pentothal (Thiopental sodium,
> C11 H17 N2 O2 S Na), and I have been unsuccessful in finding
> information on how it is produced in industry.

> If you can provide a description on how it is made or direct me
> to sources that deal with this, it will be very much appreciated.

> Thanks in advance.
>  __Richard Banks

Have you checked the Merck Index (which refers to specific patent numbers
for the manufacturing details) or to the USP?  I have an old (1961) edition of
Remington's Practice of Pharmacy, which lists the USP entry for thiopental and
gives a few lines description of how it is produced:  "Thiopental is made in the
same manner as Barbital, using 2-bromopentane to react with one of the
hydrogens in the CH2 group instead of one C2H5Br molecule, and the ethyl-1-
methylbutyl malonic ester is condensed with thiourea instead of urea."  It then
refers to another page that describes the production of barbital.  Most
libraries should have a copy of the USP.  Some might have Remington.

I hope this helps.

Lynn Willis



Sat, 10 Feb 1996 05:03:34 GMT
 General anesthesia

Quote:

>I am writing a paper on sodium pentothal (Thiopental sodium,
>C11 H17 N2 O2 S Na), and I have been unsuccessful in finding
>information on how it is produced in industry.

>If you can provide a description on how it is made or direct me
>to sources that deal with this, it will be very much appreciated.

    I'd suggest "The Organic Chemistry of Drug Synthesis", by Lednicer and
Mischer.  It's a multi-volume set that classifies {*filter*} by chemical type
rather than pharmacological action.  There's a whole chapter on
barbiturates.
--
   ******************************************************************

     Department of Chemistry                  Eastern Illinois Univ.


Sat, 10 Feb 1996 05:31:13 GMT
 General anesthesia


Fri, 19 Jun 1992 00:00:00 GMT
 General anesthesia
from The Merck Index:

Preparation is covered by US Patents 2,153,729 (1939), 2,876,225 (1959).

"Yellowish-white hygroscopic powder.  Alliaceous, garlic-like odor.  Sol
in water, {*filter*}...."

You could consult the patents themselves for a description of the
manufacture of the compound, or perhaps find it in chemical literature.

In either case, a large college library should be helpful.  Nearly all
such are open to the public at no charge.
        - Brian



Sat, 10 Feb 1996 07:38:21 GMT
 General anesthesia

There used to be a journal, I think it was called simply "Organic
Synthesis", which basically was a place for ``recipes'' to be
published. For example, someone figures out some way to vary some
common synthesis such that the yield is increased. Even if it's no
longer published I'd guess that sodium pentathol syntheses were
covered, if at all, when it was being published (the journal went back
to the beginning of the century.) It's a good resource for such
questions though you have to know the "macro expansions" or be willing
to look them up.

Anyhow, even if I'm off on the name I'm sure a librarian in any
chemistry library would know it immediately by description.

--
        -Barry Shein


Purveyors to the Trade | Voice: 617-739-0202        | Login: 617-739-WRLD



Sat, 10 Feb 1996 18:17:54 GMT
 General anesthesia


Fri, 19 Jun 1992 00:00:00 GMT
 General anesthesia

Quote:
 (Richard Banks) writes:
>I am writing a paper on sodium pentothal (Thiopental sodium,
>C11 H17 N2 O2 S Na), and I have been unsuccessful in finding
>information on how it is produced in industry.
>If you can provide a description on how it is made or direct me
>to sources that deal with this, it will be very much appreciated.

I hate to be suspicious, but aren't you the same person who just
asked what the chemical formula for thiopental was?  I have to
think that if you were writing a paper on it you wouldn't have
had much trouble finding that formula.  Since one can imagine some
fairly negative uses someone might have for one of moviedom's favorite
"truth serums", I'm not sure that it will be a major boon to mankind
to provide you with information on its manufacture.

--
David Rind



Mon, 12 Feb 1996 21:16:37 GMT
 General anesthesia

Quote:


>  (Richard Banks) writes:
>>I am writing a paper on sodium pentothal (Thiopental sodium,
>>C11 H17 N2 O2 S Na), and I have been unsuccessful in finding
>>information on how it is produced in industry.
>>If you can provide a description on how it is made or direct me
>>to sources that deal with this, it will be very much appreciated.

> I hate to be suspicious, but aren't you the same person who just
> asked what the chemical formula for thiopental was?  I have to
> think that if you were writing a paper on it you wouldn't have
> had much trouble finding that formula.  Since one can imagine some
> fairly negative uses someone might have for one of moviedom's favorite
> "truth serums", I'm not sure that it will be a major boon to mankind
> to provide you with information on its manufacture.

> --

On the other hand someone else has already posted patent no.s & other info that
is readily available from the Merck Index amongst other sources. It may be that
this person needs only to find out how to use his library; it may also be that
he is too lazy to do so & is exploiting the good will of the net. That is not a
serious criticism as many others do so as well.

To repeat: this information is available in any decent library. Censorship is
unnecessary.

I don't mind providing this or any other information that is in the public
domain to people who do not have ready access to libraries etc. I am becoming a
little more concerned about the use of the net by those who could easily obtain
the info elsewhere.

I welcome comments on these issues from others. I am sure these issues have
been addressed before. I have been lurking only for a little over six months.

I have occasionaly provided information that is readily available to me & would
not wish to discourage others from doing likewise. In some cases I should like
to see evidence of self help (what have they tried) or of the unavailability
of the usual academic library resources.

Do others have comments on these issues - Yes I am aware of the standard of the
standard FAQs which seem to be honoured more in the breach than in the
observance.

___________________________________________________________________________

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Thu, 15 Feb 1996 01:01:04 GMT
 
 [ 11 post ] 

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