Iron induced increase in adjuvant arthritis synovitis 
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 Iron induced increase in adjuvant arthritis synovitis

So according to this study .. bread .. or ANYTHING .. fortified with
iron .. could .. be a .. problem .. ?

Ann Rheum Dis. 1992 Apr;51(4):516-21. Related Articles, Links

Effect of iron complexes on adjuvant arthritis in rats.

Dabbagh AJ, Blake DR, Morris CJ.

Inflammation Group, London Hospital Medical College, United Kingdom.

When a total dose infusion of iron dextran is given to anaemic
rheumatoid patients an exacerbation of inflammatory synovitis in
previously affected joints is observed. The adjuvant arthritis model of
inflammation in rats has been used to investigate the mechanism of iron
promoted synovitis. Either iron dextran (5 mg injected intravenously)
with a dextran C control, or iron sorbitol (7.5 mg injected
intramuscularly) with a sorbitol citrate complex control was given at
the onset of clinical joint inflammation. Iron dextran significantly
increased joint inflammation (assessed by joint scoring) at days 12,
13, 14, and 16 after injection. Similarly, iron sorbitol produced a
significant increase in the joint score at days 17, 18, 19, and 21. In
addition, extensive osteoporosis was observed in the rats treated with
iron sorbitol. These pro-inflammatory effects of iron coincide with the
presence of positive results for synovial iron (III) using Perl's test
and neutrophil infiltration. The results of this study suggest that the
iron induced increase in synovitis in adjuvant arthritis is a result of
iron promoted oxidative damage and is not likely to be due to the
dextran C or the sorbitol citric acid components. It is suggested that
a similar mechanism may occur in rheumatoid patients given iron
supplements.

PMID: 1586252 [PubMed - indexed for MEDLINE]

--------------------------------------------------------------------------------

Who loves ya.
Tom

Jesus Was A Vegetarian! http://www.***.com/
Man Is A Herbivore!
http://www.***.com/
DEAD PEOPLE WALKING
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Fri, 04 Jan 2008 05:21:37 GMT
 Iron induced increase in adjuvant arthritis synovitis


Quote:
> So according to this study .. bread .. or ANYTHING .. fortified with
> iron .. could .. be a .. problem .. ?

boy rusty, if you adhere to the constraints your fears impose on you, your
diet must be a total bore.  i just had a scathingly brilliant idea!

hey, rusty!  sugar is not good for you.  salt is not good for you.  fats are
not good for you.  carbs are not good for you.  grains, fruits and veggies
have pesticides sprayed on them and are often grown in contaminated soils.
fish is polluted with mercury and other {*filter*} things.  chicken and red meats
have chemicals added to their feed.  water is not safe to drink.   you can
never tell what foods aren't contaminated, rusty.  please, don't eat or
drink anything, rusty!  it's too scary to eat or drink anything.

you are getting very sleepy, rusty.  very sleepy.  listen to the sound of my
voice---it's too scary to eat or drink anything.  it's too scary to eat or
drink anything.  it's too scary to eat or drink anything.  it's too scary to
eat or drink anything.

kate
(thinking:  if this works--we won't have to bother with rusty's goofy
obsession in the very near future!  )



Fri, 04 Jan 2008 07:00:39 GMT
 Iron induced increase in adjuvant arthritis synovitis
Kate,

Be assured and comforted that you are buried deep in the Nursing
Killfile.  We just aren't interested in your arthritis or your iron.
Call us mean, call us unprofessional, but you, your iron, and your ilk
must quit your {*filter*} crossposting, or enter the killfile, forever.

Will, CRNA



Fri, 04 Jan 2008 09:58:46 GMT
 Iron induced increase in adjuvant arthritis synovitis

Quote:

> Kate,

> Be assured and comforted that you are buried deep in the Nursing
> Killfile.  We just aren't interested in your arthritis or your iron.
> Call us mean, call us unprofessional, but you, your iron, and your ilk
> must quit your {*filter*} crossposting, or enter the killfile, forever.

 It works both ways.   GOOD-BYE forever.


Fri, 04 Jan 2008 14:15:20 GMT
 Iron induced increase in adjuvant arthritis synovitis
What .. part .. OF .. "giving iron supplements to a mammal WITH ..
arthritis .. is a BAD .. thing .." .. don't you .. understand .. ?

Heh .. heh ..

Seems if you give iron supplements to animals .. OR .. children with
arthritis .. it .. HURTS .. them ..

But .. it seems .. the FACT .. it HURTS .. animals AND / or children ..
makes NO .. nevermind to .. YOU ..

I am just happy that .. you don't realize .. that when it hurts animals
and children .. it very likely ALSO hurts .. you ..

That means since you didn't ."go to the wall for the kids .. " .. when
I first posted the supplements hurting KIDS .. study .. means by NOT ..
advocating FOR .. the .. kids .. you .. effectively cut your .. OWN ..
throat ..

Heh .. heh ..

Looks .. good .. on .. ya ..

EXPERIMENTAL BIOLOGY UPDATE: Arthritic kids' iron supplements may
hasten joint deterioration
By Diana Swift
WWASHINGTON, D.C. - The iron supplements that many arthritic children
take to combat concomitant anemia may be hastening the deterioration of
their joints, Houston researchers say.
Led by biologist Roman Shypailo of the Children's Nutrition Research
Centre at Baylor College of Medicine, a Texas team looked at eight
children being treated for juvenile rheumatoid arthritis. The patients,
aged five to 15 years, received an intravenous radioactive tracer dose
of iron (0.03 microsievert). Iron activity in affected joints was
monitored on a position/energy-sensitive gamma counter, while a second
machine monitored whole-body iron retention. Iron deposition was
measured two hours post-infusion and again at days seven, 14, 28 and
56.
Anemic
"We found that iron excessively accumulates in arthritic joints and
probably contributes to the chronic damage," said Shypailo. "That puts
you between a rock and a hard place because many of these arthritic
kids are anemic and need iron supplements, which may worsen the
disease."
The study found a high level of agreement between the joint data and
the whole-body data, with a greater than 90% retention rate of the
infused iron both in joints and systemically. Furthermore, six of eight
patients showed increased uptake at the affected joints: 165% over the
first 30 days compared with initial uptake at two hours.
The next step, he says, is to see if there is excessive deposition of
dietary iron in arthritic joints.

IRON DEPOSITION IN THE JOINTS OF CHILDREN WITH JUVENILE RHEUMATOID
ARTHRITIS

Author(s):
SHYPAILO ROMAN J
ELLIS KENNETH J
PEREZ MARIA
ABRAMS STEVEN A

Interpretive Summary:
We wanted to develop an accurate and noninvasive way of
determining the amount of iron deposited in the joints of
patients with juvenile rheumatoid arthritis. Children with JRA
often develop excess iron in their joints, so doctors need a
way of monitoring the iron level, particularly when prescribing
iron supplements for the common problem of anemia. However, the
only method currently available is to take a biopsy. We adapted
a machine called a gamma counter to measure the iron in eight
patients' joints after giving them an iron isotope by vein.
Then we compared the results with the total amount of iron in
their bodies, measured by a whole-body counter. We found that
we had developed an accurate new way of measuring iron in these
patients' joints. We also found that six of the eight subjects
had excess uptake of the iron isotope in their joints. That
provided a signal that a preponderance of JRA patients are
prone to have this problem, and clinicians should take special
care to monitor them for it. Moreover, this is the first time a
noninvasive way of performing this measurement has been
available.

Keywords:
energy reproduction growth body composition women infants
children water potassium bioelectrical impedance conductance
bromide space lactating iron adipose tissue lipid motabolism
beta-adrenergic receptor cell culture neutron activation
nitrogen carbon calcium sodium chlorine phosphorus hormonal
changes differentiation adipocyte hnrim021125

Contact:
USDA/ARS CHILDREN'S NUTR
1100 BATES ST.
HOUSTON
TX 77030
FAX: (713)798-7130

Approved Date: 1999-01-07
______________________________________________________________________

TEKTRAN
United States Department of Agriculture
Agricultural Research Service

Updated: 1999-01-16

Who loves ya.
Tom

Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking



Fri, 04 Jan 2008 21:06:16 GMT
 Iron induced increase in adjuvant arthritis synovitis

Quote:

> What .. part .. OF .. "giving iron supplements to a mammal WITH ..
> arthritis .. is a BAD .. thing .." .. don't you .. understand .. ?

> Heh .. heh ..

> Seems if you give iron supplements to animals .. OR .. children with
> arthritis .. it .. HURTS .. them ..

> But .. it seems .. the FACT .. it HURTS .. animals AND / or children ..
> makes NO .. nevermind to .. YOU ..

> I am just happy that .. you don't realize .. that when it hurts animals
> and children .. it very likely ALSO hurts .. you ..

> That means since you didn't ."go to the wall for the kids .. " .. when
> I first posted the supplements hurting KIDS .. study .. means by NOT ..
> advocating FOR .. the .. kids .. you .. effectively cut your .. OWN ..
> throat ..

> Heh .. heh ..

> Looks .. good .. on .. ya ..

You only typed . 98 times, two short of quota. Isn't that a parole
violation for you, Tom?

--
spammage trappage: replace fishies_ with yahoo

I'm going to die rather sooner than I'd like. I tried to protect my
neighbours from crime, and became the victim of it. Complications in
hospital following this resulted in a serious illness. I now need a bone
marrow transplant. Many people around the world are waiting for a marrow
transplant, too. Please volunteer to be a marrow donor:
http://www.abmdr.org.au/
http://www.marrow.org/



Sat, 05 Jan 2008 02:32:14 GMT
 Iron induced increase in adjuvant arthritis synovitis
Ann Rheum Dis 1989 May;48(5):382-8

Investigation of the anti-inflammatory properties of
hydroxypyridinones.

Hewitt SD, Hider RC, Sarpong P, Morris CJ, Blake DR
Cancer Research Unit, University of York, Heslington.

Synovial iron deposition associated with rheumatoid disease may result
in the
production of highly reactive oxygen free radicals, leading to tissue
damage.
This chain of events can be interrupted by iron chelation. Families of
strong
iron (III) chelators have been tested for their iron scavenging
properties in
vitro and their effects assessed in vivo using a rat model of
inflammation. All
the chelators competed successfully for iron with apotransferrin, and
some
removed up to 34% of iron from ferritin. The best anti-inflammatory
effects
were achieved with the most hydrophilic chelators and those which
chelated iron
most avidly. Activity was dependent on dose. The route of
administration was
also an important factor with lower affinity chelators. This work
introduces a
range of simple bidentate iron chelators, which under certain
conditions exceed
desferrioxamine in their iron scavenging abilities, and some of which,
in this
simple animal model, approach indomethacin in their anti-inflammatory
capabilities.

PMID: 2730166, UI: 89272259

Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
<<



Sat, 05 Jan 2008 07:51:23 GMT
 Iron induced increase in adjuvant arthritis synovitis
Got something to say about iron OR .. arthritis .. ?

Then S-T-F-U ..

Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking



Sat, 05 Jan 2008 08:05:33 GMT
 Iron induced increase in adjuvant arthritis synovitis
Got something to say about iron OR .. arthritis .. ?

Then S-T-F-U ..

Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking



Sat, 05 Jan 2008 08:06:18 GMT
 
 [ 11 post ] 

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