Brain Iron in Multiple Sclerosis 
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 Brain Iron in Multiple Sclerosis

BRAIN

Quantitative Assessment of Iron Accumulation in the Deep Gray Matter
of Multiple Sclerosis by Magnetic Field Correlation Imaging
Y. Gea, J.H. Jensena, H. Lua, J.A. Helperna, L. Milesa, M. Inglesea,
J.S. Babba, J. Herbertb and R.I. Grossmana
a Center for Biomedical Imaging, Department of Radiology, New York
University Medical Center, New York, NY
b Department of Neurology, MS Care Center, Hospital for Joint
Diseases, New York University School of Medicine, New York, NY

Please address correspondence to Yulin Ge, MD, Department of Radiology/
Center for Biomedical Imaging, New York University School of Medicine,
650 First Ave, 6th Floor, Room 615, New York, NY 10016; e-mail:

BACKGROUND AND PURPOSE: Deposition of iron has been recognized
recently as an important factor of pathophysiologic change including
neurodegenerative processes in multiple sclerosis (MS). We propose
that there is an excess accumulation of iron in the deep gray matter
in patients with MS that can be measured with a newly developed
quantitative MR technique-magnetic field correlation (MFC) imaging.

MATERIALS AND METHODS: With a 3T MR system, we studied 17 patients
with relapsing-remitting MS and 14 age-matched healthy control
subjects. We acquired MFC imaging using an asymmetric single-shot echo-
planar imaging sequence. Regions of interest were selected in both
deep gray matter and white matter regions, and the mean MFC values
were compared between patients and controls. We also correlated the
MFC data with lesion load and neuropsychologic tests in the patients.

RESULTS: MFC measured in the deep gray matter in patients with MS was
significantly higher than that in the healthy controls (P  .03), with
an average increase of 24% in the globus pallidus, 39.5% in the
putamen, and 30.6% in the thalamus. The increased iron deposition
measured with MFC in the deep gray matter in the patients correlated
positively with the total number of MS lesions (thalamus: r = 0.61, P
= .01; globus pallidus: r = 0.52, P = .02). A moderate but significant
correlation between the MFC value in the deep gray matter and the
neuropsychologic tests was also found.

CONCLUSION: Quantitative measurements of iron content with MFC
demonstrate increased accumulation of iron in the deep gray matter in
patients with MS, which may be associated with the disrupted iron
outflow pathway by lesions. Such abnormal accumulation of iron may
contribute to neuropsychologic impairment and have implications for
neurodegenerative processes in MS.

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DEAD PEOPLE WALKING
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Tue, 20 Apr 2010 23:27:56 GMT
 Brain Iron in Multiple Sclerosis

<<snip>>
DFO reduces disruption of the BBB
<<snip>>

Ophthalmic Res. 1994;26(5):310-23.  Related Articles, Links

Conjugated deferoxamine reduces {*filter*}-brain barrier disruption in
experimental
optic neuritis.

Guy J, McGorray S, Qi X, Fitzsimmons J, Mancuso A, Rao N.

Department of Ophthalmology, University of Florida, Gainesville.

The purpose of this paper was to investigate the role of deferoxamine
(DFO)
scavenging of hydroxyl radical (.OH) on disruption of the {*filter*}-brain
barrier
(BBB) and demyelination in experimental optic neuritis. Eigh{*filter*}
strain-13
guinea pigs were sensitized for experimental allergic
encephalomyelitis. Nine
animals received 100 mg/kg of hydroxyethyl starch-conjugated (HES) DFO
by daily
intraperitoneal injection commencing the day of antigenic
sensitization. Nine
paired litter mates received daily IP injections of HES. Serial fat-
suppressed
magnetic resonance imaging of the optic nerves was obtained with a T2
weighting
(T2w) to evaluate demyelination and after intravascular administration
of
Gd-DTPA to evaluate BBB disruption. The intensity of Gd-DTPA
enhancement and
T2w signal of the optic nerves was quantitated 3, 7, 10 and 14 days
after
antigenic sensitization. Animals were then sacrificed and the optic
nerves
processed for light and transmission electron microscopy with
ultracytochemical
localization of endogenous hydrogen peroxide (H2O2) and immunogold
colocalization of extravasated serum albumin. The area of the optic
nerve head,
intensity of toluidine blue staining, and the cellular infiltrate
were
digitized and quantitated. Administration of HES-DFO significantly
reduced the
intensity of Gd-DTPA enhancement in the optic nerves of HES-DFO-
treated animals
compared to paired control HES animals (p = 0.0236), with the mean
difference
between control and treated animals of 19.39. The difference in T2w
signal was
not significant (p = 0.39), with a mean difference between control and
treated
animals of -5.51. The intensity of toluidine blue staining of optic
nerve
specimens was slightly less with HES-DFO compared to untreated animals
(mean
pair difference 2.48), and the inflammatory infiltrate was reduced
with HES-DFO
compared to untreated animals (mean pair difference = 61.57); these
differences
were not statistically significant. In the optic nerve specimens of
both groups
cerium perhydroxide-derived H2O2 reaction product was evident in a
pre{*filter*}ly perivascular and perineural distribution. Immunogold-
labeled
serum albumin showed extravasation at foci of perivascular
inflammation in both
the presence and absence of H2O2-derived reaction product. Conjugated
DFO
reduces disruption of the BBB, as measured by Gd-DTPA enhancement,
suggesting
the .OH radical generated from perivascular H2O2 may play a role in
alterations
of vascular permeability in experimental optic neuritis.

PMID: 7533278 [PubMed - indexed for MEDLINE]

--------------------------------------------------------------------------

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://www.***.com/

Man Is A Herbivore!
http://www.***.com/

DEAD PEOPLE WALKING
http://www.***.com/

Quote:
> BRAIN

> Quantitative Assessment of Iron Accumulation in the Deep Gray Matter
> of Multiple Sclerosis by Magnetic Field Correlation Imaging
> Y. Gea, J.H. Jensena, H. Lua, J.A. Helperna, L. Milesa, M. Inglesea,
> J.S. Babba, J. Herbertb and R.I. Grossmana
> a Center for Biomedical Imaging, Department of Radiology, New York
> University Medical Center, New York, NY
> b Department of Neurology, MS Care Center, Hospital for Joint
> Diseases, New York University School of Medicine, New York, NY

> Please address correspondence to Yulin Ge, MD, Department of Radiology/
> Center for Biomedical Imaging, New York University School of Medicine,
> 650 First Ave, 6th Floor, Room 615, New York, NY 10016; e-mail:

> BACKGROUND AND PURPOSE: Deposition of iron has been recognized
> recently as an important factor of pathophysiologic change including
> neurodegenerative processes in multiple sclerosis (MS). We propose
> that there is an excess accumulation of iron in the deep gray matter
> in patients with MS that can be measured with a newly developed
> quantitative MR technique-magnetic field correlation (MFC) imaging.

> MATERIALS AND METHODS: With a 3T MR system, we studied 17 patients
> with relapsing-remitting MS and 14 age-matched healthy control
> subjects. We acquired MFC imaging using an asymmetric single-shot echo-
> planar imaging sequence. Regions of interest were selected in both
> deep gray matter and white matter regions, and the mean MFC values
> were compared between patients and controls. We also correlated the
> MFC data with lesion load and neuropsychologic tests in the patients.

> RESULTS: MFC measured in the deep gray matter in patients with MS was
> significantly higher than that in the healthy controls (P  .03), with
> an average increase of 24% in the globus pallidus, 39.5% in the
> putamen, and 30.6% in the thalamus. The increased iron deposition
> measured with MFC in the deep gray matter in the patients correlated
> positively with the total number of MS lesions (thalamus: r = 0.61, P
> = .01; globus pallidus: r = 0.52, P = .02). A moderate but significant
> correlation between the MFC value in the deep gray matter and the
> neuropsychologic tests was also found.

> CONCLUSION: Quantitative measurements of iron content with MFC
> demonstrate increased accumulation of iron in the deep gray matter in
> patients with MS, which may be associated with the disrupted iron
> outflow pathway by lesions. Such abnormal accumulation of iron may
> contribute to neuropsychologic impairment and have implications for
> neurodegenerative processes in MS.

> http://www.***.com/

> Who loves ya.
> Tom

> Jesus Was A Vegetarian! http://www.***.com/

> Man Is A Herbivore! http://www.***.com/

> DEAD PEOPLE WALKING http://www.***.com/



Fri, 23 Apr 2010 12:34:58 GMT
 Brain Iron in Multiple Sclerosis
"cumulation of iron <<"

Which disorder of the normal iron level control is this one?

Jesus ate a mediterranean diet.



Fri, 23 Apr 2010 22:42:28 GMT
 Brain Iron in Multiple Sclerosis

 "cumulation of iron" Which disorder of the normal iron level control
is this one? <<

You don't understand .. ?

"Iron Accumulation in the Deep Gray Matter of Multiple Sclerosis"

You don't understand .. ?

Means you are .. stupid .. ?

I think it does ..

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk



Sat, 24 Apr 2010 03:39:58 GMT
 Brain Iron in Multiple Sclerosis
""Iron Accumulation in the Deep Gray Matter of Multiple Sclerosis""

Has the genetic disorder which upsets the normal iron level control been
discovered yet for this?

Jesus ate a mediterranean diet.



Sat, 24 Apr 2010 04:38:28 GMT
 Brain Iron in Multiple Sclerosis

 Has the genetic disorder which upsets the normal iron level control
been
 discovered yet for this? <<

Actually it has been linked to the same .. problem as the lupus ..
people ..

Do you know what problem the lupus people .. have .. ?

You must know .. I spoke to you not more than five hours ago or so ..

You must remember the .. part .. about the portion about the
proportion .. ?

Or was it the portion about the part in the proportion .. ?

Can you remember .. you've gotten me .. confused ..

Ah that's right .. they have a high rate of people with MS who also
have the genes for .. ? ..

Hmmm ..

Can't quite remember ..

But I do know they ARE looking for iron because of this .. gene ..
connection of some sort .. ?

Maybe you can remember it for the souls ..

Eh ..

Do you think you .. can ..

I'll try to in the meantime ..

OK .. ?

Great ..

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

Quote:

> Jesus ate a mediterranean diet.



Sat, 24 Apr 2010 07:26:46 GMT
 Brain Iron in Multiple Sclerosis
Now the iron notion is dead as a dodo we can look for the real causes of
iron overload.  This and other threads reveal the genetic disorders that
cause the normal control of iron levels to be disrupted.  The more
scince looks for them the more genetic causes they find.

Now we have abandoned the iron notion and are moving into the era of the
altitude notion this is good news.

Jesus ate a mediterranean diet.



Sat, 24 Apr 2010 08:42:54 GMT
 Brain Iron in Multiple Sclerosis

Now we have abandoned the iron notion and are moving into the era of
the
 altitude notion this is good news. <<

We .. have abandoned .. ?

You have abandoned .. nobody .. except .. a bunch of dead .. kids ..

Isn't that .. right .. boy ..

Good thing .. everyone isn't quite as adept as you greaseballs .. at
abandoning .. children ..

Evidenced BY .. UK .. boy scouts with broken bones .. and .. piles
upon piles of dead malaria stricken .. children ..

Thought I'd remind you of them .. again ..

WE know you .. have forgotten them .. already.

HOW do we .. know .. ?

Heh .. heh ..

INsight ..

Eh ..

HOW were the holidays .. you've got a few more coming before you are
out here in the real world .

Make good use of them .. because there are not that many holidays when
you .. gettoit ..

But .. then again since one cannot expect YOU to EVER .. gettoit ..
you should be able to take a few of those six month holidays you boys
are .. KNOWN .. for ..

Sets your sights .. high ..

And you will succeed ..

Use .. holidays .. as a .. marker ..

Success based on days .. off ..

Good marker ..

For .. **useless** fks .. like .. yourself ..

Please .. take a few MORE .. holidays ..

Don't think the kids .. can survive too many more of your days ..
at .. work.

Can they ..

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

Quote:

> Jesus ate a mediterranean diet.



Sat, 24 Apr 2010 19:38:02 GMT
 Brain Iron in Multiple Sclerosis
In science when a line of research fails it is abandoned and research
turns to other possible lines of answers.  

The iron notion has been in fact dead for a long time, if it ever was
alive being left aside for the moment, and with the recent test of the
notion in india and the line of research showing the body has ways of
controling iron levels it is gone for good.

We are now turning to the altitude notion for answers.

Jesus lived near the world's lowest altitude.

Jesus ate a mediterranean diet.



Sun, 25 Apr 2010 09:44:15 GMT
 Brain Iron in Multiple Sclerosis

 **useless**

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk



Sun, 25 Apr 2010 22:22:57 GMT
 Brain Iron in Multiple Sclerosis
" **useless**"

Ah, another keyboard gone, the "." key just can't take it.

Jesus ate a mediterranean diet.



Mon, 26 Apr 2010 03:51:13 GMT
 Brain Iron in Multiple Sclerosis

 **useless** .. fk ..

Who loves ya.
Tom

Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com

Man Is A Herbivore!
http://tinyurl.com/a3cc3

DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk



Mon, 26 Apr 2010 07:49:50 GMT
 
 [ 12 post ] 

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