Gamma-tocotrienol is required for normal vitamin D metabolism in
female rats
Indian Journal of Pharmacology, Vol. 37, No. 5, 2005, pp. 309-314
Norazlina M, Ng FW, Ima-Nirwana S
Abstract

Objective: To study the effects of vitamin E deficiency and
supplementation of vitamin D and bone metabolism in female Sprague-
Dawley rats.
Materials and Methods: Rats weighing between 200 and 250 g were
divided into six groups, that is, rats fed on (a) normal rat chow diet
(RC), (b) vitamin E-deficient diet (VED) (c) VED diet supplemented
with 60 mg/kg -tocopherol acetate (ATF), (d) VED diet supplemented
with 60 mg/kg ?-tocotrienol (GTT), (e) VED diet supplemented with 60
mg/kg Tocomin (R) (TOC) and (f) baseline control group which was killed
without treatment (BC). Treatment was given for 2 months. Serum 1,25-
dihydroxyvitamin D3, serum total calcium, urine calcium, left femur,
and fourth lumbar vertebra calcium content and left femur length were
measured.
Results: In the VED and ATF groups, activation of vitamin D to 1,25-
dihydroxyvitamin D3 was inhibited and calcium reabsorption in the
kidneys were increased. Both the effects seen in ATF and GTT groups
were observed in the TOC group. The GTT group was protected from the
effects of the vitamin E-deficient diet. Calcium content of the fourth
lumbar vertebra was also decreased by vitamin E- deficiency, which was
not reversed by vitamin E supplementation.
Conclusion: ?-tocotrienol and not -tocopherol protects vitamin D
metabolism and calcium homeostasis from the effects of vitamin E-
deficiency.
Keywords
Calcium homeostasis, -tocopherol, vitamin E-deficiency

(c) Copyright 2005 Indian Journal of Pharmacology.
Alternative site location: http://www.***.com/
Indian Journal of Pharmacology
Medknow Publications on behalf of Indian Pharmacological Society
ISSN: 0253-7613
Vol. 37, No. 5, 2005, pp. 309-314
Bioline Code: ph05080

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