Gastric acid / PPIs / GERD etc etc 
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 Gastric acid / PPIs / GERD etc etc

Acid is a normal component of gastric (stomach) juice. Its main role is to
protect us from any microbes that may be in our food/drink. we have more
than enough for this role. pH of the stomach is often between 1-2. A
gastric pH of 3-4 is enough for a satisfactory bactericidal effect. (If
anyone undersatnds logarithmic scales, they will see the orders of
magnitude being discussed).

GERD (gastroesophageal reflux disease) is a condition associated with
symptoms and/or pathological damage to the esophagus caused by excessive
reflux of acidic gastric juice into the esophagus. PPIs (e.g. omeprazole
"Prilosec", and lansoprazole "Prevacid") are the most effective agents for
this condition. i do not agree that they should only be reserved for very
srrious cases. They are effective in GERD of all grades of severity.  To
date, these are very effective and safe {*filter*}. They do not (and cannot)
cause complete abolition of gastric acid production. During treatment, a
patient's intragastric pH will still be below 3 (i.e. more acidic than 3)
for appreciable parts of the day.

I would be happy to hear from anyone with further questions on this. I am
a physician and gastroenterologist with particular interest in this area.



Sat, 08 Nov 1997 03:00:00 GMT
 
 [ 1 post ] 

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