Heme iron absorption NOT substantially reduced as iron stores increase 
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 Heme iron absorption NOT substantially reduced as iron stores increase

This is a .. bad .. thing ..

Secondary siderosis ..

Research Project: MINERAL UTILIZATION AND BIOAVAILABILITY IN THE 21ST
CENTURY, WITH CHANGING DIETS AND AGRICULTURAL PRACTICES
Location: Grand Forks Human Nutrition Research Center

Title: Absorption of Nonheme, But Not Heme Iron, Is Substantially
Reduced with High Iron Stores

Author
Hunt, Janet

Submitted to: American Dietetic Association Annual Meeting
Publication Type: Abstract
Publication Acceptance Date: April 1, 2006
Publication Date: August 1, 2006
Citation: Hunt, J.R. 2006. Absorption of nonheme, but not heme iron, is
substantially reduced with high iron stores [abstract]. Journal of the
American Dietetic Association. 106(8)S2:A-42.

Technical Abstract: Humans absorb heme iron from meat, poultry and fish
more efficiently than nonheme iron, and high consumption may increase
body iron stores, and possibly oxidative stress. Results from previous
studies of heme and nonheme iron bioavailability, measured separately
for men and for women, were combined to model the relative absorption
of each form of iron in relation to body iron stores. Iron absorption
was measured in healthy men (n=14) and premenopausal women (n=18)
consuming controlled, high bioavailability diets. Adjusted for
individual energy intake, the diets provided 10-14 oz/d of meat or
poultry, refined grains and cereal products, no coffee or tea, and
greater than or equal to 75 mg ascorbic acid with each meal. By
analysis, the diet contained 12.9 mg iron/2500 kcal, with 1.4 mg or 11%
as heme iron. Iron absorption was measured by radiolabeling the 2-d
menu with 59FeCl3 and 55Fe hemoglobin, and measuring whole body and
erythrocyte retention after 2 wk. With all variables logarithmically
transformed, total iron absorption (0.4 to 4.5 mg/d) and nonheme iron
absorption, but not heme iron absorption, were inversely related to
serum ferritin (4 to 308 micro g/L) (R2 = 0.66, p<0.01). Subjects with
the lowest iron stores absorbed iron mostly in the nonheme form, and
heme iron accounted for 15-20% of the iron absorbed. With higher iron
stores, nonheme iron absorption decreased, with the result that heme
iron accounted for half of the iron absorbed by subjects with serum
ferritin greater than or equal to 150 micro g/L. Unlike nonheme iron,
heme iron absorption is not substantially reduced as iron stores
increase.
 Project Team

 HUNT, JANET
 REEVES, PHILIP
 CANFIELD, WESLEY
 COMBS, GERALD - JERRY

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Sun, 22 Mar 2009 14:05:38 GMT
 
 [ 1 post ] 

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